Effect of Continuous Irradiation with a Very Low Dose of Gamma Rays on Life Span and the Immune System in SJL Mice Prone to B-Cell Lymphoma

Lacoste-Collin, Laetitia; Jozan, S.; Cances-Lauwers, Valérie; Pipy, Bernard; Gasset, G.; Caratero, C; Courtade-Saïdi, Monique

doi:10.1667/rr1007.1

Cited by 45 publications

(40 citation statements)

References 27 publications

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“…Dendritic cells differentiated from bone marrow cells play key roles in generating immune responses. Previous results showed that low dose radiation stimulated immune systems and induced hematopoietic hormesis (Zhang et al 2010;Liu et al 1987;Li et al 2004;Lacoste-Collin et al 2007). Thus, we investigated whether low dose radiation had an effect on differentiation of bone marrow cells into dendritic cells.…”

Section: Modulation Of Bone Marrow Cells By Low Dose Radiationmentioning

confidence: 99%

“…Previous studies have demonstrated the stimulating effects of low dose radiation (termed 'hormesis') on the immune and hematopoietic systems (Zhang et al 2010;Liu et al 1987;Li et al 2004;Lacoste-Collin et al 2007). Chronic low dose radiation was shown to stimulate immune systems, resulting in controlling the proliferation of cancer cells, maintain immune balance and induce hematopoietic hormesis, such as hematopoietic progenitor cell proliferation and peripheral blood mobilization.…”

Section: Introductionmentioning

confidence: 99%

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Effect of Low dose Radiation on Differentiation of Bone Marrow Cells into Dendritic Cells

et al. 2012

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ᮀ Low dose radiation has been shown to be beneficial to living organisms using several biological systems, including immune and hematopoietic systems. Chronic low dose radiation was shown to stimulate immune systems, resulting in controlling the proliferation of cancer cells, maintain immune balance and induce hematopoietic hormesis. Since dendritic cells are differentiated from bone marrow cells and are key players in maintaining the balance between immune activation and tolerance, it may be important to further characterize whether low dose radiation can influence the capacity of bone marrow cells to differentiate into dendritic cells. We have shown that bone marrow cells from low doseirradiated (γ-radiation, 0.2Gy, 15.44mGy/h) mice can differentiate into dendritic cells that have several different characteristics, such as expression of surface molecules, cytokine secretion and antigen uptake capacity, when compared to dentritic cells differentiated from the control bone marrow cells. These differences observed in the low dose radiation group can be beneficial to living organisms either by activation of immune responses to foreign antigens or tumors, or maintenance of self-tolerance. To the best of our knowledge, this is the first report showing that total-body low dose radiation can modulate the capacity of bone marrow cells to differentiate into dendritic cells.

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Section: Modulation Of Bone Marrow Cells By Low Dose Radiationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of Low dose Radiation on Differentiation of Bone Marrow Cells into Dendritic Cells

et al. 2012

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“…LDR (Low Dose Radiotherapy) up-regulated genes that encode cytokines at doses as low as 100 mGy (Barcellos-Hoff 1998). Continuous gamma ray exposure (100 mGy per year) prolonged lifespan, suppressed B-cell lymphoma formation and increased CD49 + cell production in mice (Lacoste-Collin et al 2007). A single dose of 100-200 mGy x-rays to mice reduced lung metastases from implanted syngeneic L1 sarcoma cells, while also increasing NK cell numbers (Cheda et al 2004).…”

Section: Tumor Cell Response At Low Dosesmentioning

confidence: 99%

Potential Treatment of Inflammatory and Proliferative Diseases by Ultra-Low Doses of Ionizing Radiations

Sanders¹

2012

Dose-Response

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ᮀ Ultra-low doses and dose-rates of ionizing radiation are effective in preventing disease which suggests that they also may be effective in treating disease. Limited experimental and anecdotal evidence indicates that low radiation doses from radon in mines and spas, thorium-bearing monazite sands and enhanced radioactive uranium ore obtained from a natural geological reactor may be useful in treating many inflammatory conditions and proliferative disorders, including cancer. Optimal therapeutic applications were identified via a literature survey as dose-rates ranging from 7 to 11µGy/hr or 28 to 44 times world average background rates. Rocks from an abandoned uranium mine in Utah were considered for therapeutic application and were examined by γ-ray and laser-induced breakdown fluorescence spectroscopy. The rocks showed the presence of transuranics and fission products with a γ-ray energy profile similar to aged spent uranium nuclear fuel (93% dose due to β particles and 7% due to γ rays). Mud packs of pulverized uranium ore rock dust in sealed plastic bags delivering bag surface β,γ dose-rates of 10-450 µGy/h were used with apparent success to treat several inflammatory and proliferative conditions in humans.

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“…40% of animal studies showed a hormesis-like response, i.e., a decrease in spontaneous cancer incidence at low radiation doses (Duport 2003). Moreover, at continuous very low IR dose (10 cGy y Ϫ1 ) no adverse effects were observed on life span and incidence of lymphoma in SJL female mice (Lacoste-Collin et al 2007).…”

Section: Animal Data On Radiocarcinogenesismentioning

confidence: 99%

Does Scientific Evidence Support a Change From the LNT Model for Low-Dose Radiation Risk Extrapolation?

Averbeck¹

2009

Health Physics

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The linear no-threshold (LNT) model has been widely used to establish international rules and standards in radiation protection. It is based on the notion that the physical energy deposition of ionizing radiation (IR) increases carcinogenic risk linearly with increasing dose (i.e., the carcinogenic effectiveness remains constant irrespective of dose) and, within a factor of two, also with dose-rate. However, recent findings have strongly put into question the LNT concept and its scientific validity, especially for very low doses and dose-rates. Low-dose effects are more difficult to ascertain than high-dose effects. Epidemiological studies usually lack sufficient statistical power to determine health risks from very low-dose exposures. In this situation, studies of the fundamental mechanisms involved help to understand and assess short- and long-term effects of low-dose IR and to evaluate low-dose radiation risks. Several lines of evidence demonstrate that low-dose and low dose-rate effects are generally lower than expected from high-dose exposures. DNA damage signaling, cell cycle checkpoint activation, DNA repair, gene and protein expression, apoptosis, and cell transformation differ qualitatively and quantitatively at high- and low-dose IR exposures, and most animal and epidemiological data support this conclusion. Thus, LNT appears to be scientifically invalid in the low-dose range.

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Effect of Continuous Irradiation with a Very Low Dose of Gamma Rays on Life Span and the Immune System in SJL Mice Prone to B-Cell Lymphoma

Cited by 45 publications

References 27 publications

Effect of Low dose Radiation on Differentiation of Bone Marrow Cells into Dendritic Cells

Effect of Low dose Radiation on Differentiation of Bone Marrow Cells into Dendritic Cells

Potential Treatment of Inflammatory and Proliferative Diseases by Ultra-Low Doses of Ionizing Radiations

Does Scientific Evidence Support a Change From the LNT Model for Low-Dose Radiation Risk Extrapolation?

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