Effect of Cordyceps militaris extract and active constituents on metabolic parameters of obesity induced by high-fat diet in C58BL/6J mice

Kim, Seon Beom; Ahn, Byeongwoo; Kim, Myounghwan; Ji, Hyeong-Jin; Shin, See‐Ok; Hong, In Pyo; Kim, Chul Young; Hwang, Bang Yeon; Lee, Mi Kyeong

doi:10.1016/j.jep.2013.10.064

Cited by 60 publications

(45 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A previous investigation of red algae which contains 45.9 and 15.4% water soluble dietary fiber and insoluble dietary fiber, respectively, showed similar results of serum and fecal lipid profile as ours [38]. In addition, Kim et al found two new anti-obesity compounds from Cordyceps, cordyrroles A and B, which are effectively inhibited pancreatic lipase activity [39]. Surprisingly, the OSM use in this study also decreased the liver TG levels, but it did not enhance (p>0.05) the TG output in feces, so it may not be related to lipase activities.…”

Section: Discussionsupporting

confidence: 67%

Preventive Effects of Ophiocordyceps sinensis Mycelium on High-Fat Diet Induced Lipid Dysregulation and Hepatic Inflammation of Mice

Chou¹,

Lin²,

Wu³

et al. 2017

JFNR

View full text Add to dashboard Cite

Dyslipidemia is regarded as one of risk factors related to cardiovascular disease and hepatosteatosis widely. Due to westernized diet habits and lifestyle changes, there is a high prevalence of those lipid-dysregulated diseases, i.e. fatty liver, hyperlipidemia, diabetes etc. However, the liver holds the lipid homeostasis so hepatoprotective nutraceuticals against high-fat diet (HFD) induced dyslipidemia may be potential for a public demand. This study demonstrated that OSM containing 10% polysaccharides and 0.25% adenosine can decrease (p<0.05) serum and liver triglyceride (TG) contents, and meanwhile, increased (p<0.05) fecal cholesterol (TC) levels in HFD fed mice. Moreover, Ophiocordyceps sinensis mycelium (OSM) also decreased (p<0.05) serum low-density lipoprotein cholesterol (LDLC) levels and the atherosclerosis index (LDLC/high-density lipoprotein cholesterol (HDLC)) in HFD fed mice. Regarding the liver damage, OSM supplementation attenuated serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) values, and liver tumor necrosis factor-α (TNF-α) levels in HFD fed mice. Taken together, OSM showed an ameliorative effect of the hepatosteatosis development and lipid-dysregulated-related diseases in a HFD habit.

show abstract

Section: Discussionsupporting

confidence: 67%

Preventive Effects of Ophiocordyceps sinensis Mycelium on High-Fat Diet Induced Lipid Dysregulation and Hepatic Inflammation of Mice

Chou¹,

Lin²,

Wu³

et al. 2017

JFNR

View full text Add to dashboard Cite

show abstract

“…The weekly food intake of mice fed an HFD was lower than that of mice fed a ND, and there were significant differences among the HFD fed groups. Therefore, the FERs of the HFD + CRF groups were significantly lower than that of the HFD group, thereby preventing the HFD‐induced increases in body weight (Sung et al ., ; Kim et al ., ).…”

Section: Discussionmentioning

confidence: 99%

Effect of the Capsicoside G‐rich Fraction from Pepper (Capsicum annuum L.) Seeds on High‐fat Diet‐induced Obesity in Mice

Sung

Jeong

2016

Phytotherapy Research

View full text Add to dashboard Cite

Obesity is one of the most common metabolic syndromes and is a major threat to human health worldwide. Given the size of this problem, there is growing interest in natural agents that may decrease obesity. In this study, we investigated the anti-obesity effect of a capsicoside G-rich fraction (CRF; 13.35% capsicoside G) isolated from pepper seeds in diet-induced obese mice. C57BL/6J mice were fed either a normal diet or a high-fat diet (HFD), with or without CRF (HFD + CRF; 10 and 100 mg/kg body weight). The body weight and food efficiency ratio of mice fed HFD + CRF were lower in comparison to that of mice fed only an HFD. Epididymal adipose tissue weight and adipocyte hypertrophy were significantly lower in HFD + CRF mice than in HFD mice. The fat deposition in the liver of mice fed HFD + CRF was lower compared to that of mice fed only an HFD. CRF significantly reversed the HFD-induced elevation of the expression of key adipocyte differentiation regulators, including peroxisome proliferator-activated receptor γ, CCAAT/enhancer-binding protein α, sterol regulatory element binding protein 1c, and their target genes. These results suggest that CRF could be used as dietary therapy for the prevention of obesity and obesity-related metabolic diseases. Copyright © 2016 John Wiley & Sons, Ltd.

show abstract

“…C. militaris has received considerable attention in recent years due to the recognition that it has biological effects with healthstimulating properties and medicinal effects. A wide range of bioactive components in C. militaris such as cordycepin, cordyceps polysaccharide, cordycepic acid, fibrinolytic enzyme, and superoxide dismutase have been reported to possess various biological properties, including antivirus, blood pressure reduction, anticancer, antiaging, hypoglycemic, antineoplastic and inhibition of inflammation (Cui et al, 2008;Das, Masuda, Sakurai, & Sakakibara, 2010;Kim et al, 2014;Wang et al, 2012;Zhu et al, 2013). Because of its attractive beneficial effects and rarity in nature, C. militaris is considered as one of the most expensive mushrooms in China (Xiao et al, 2014), and C. militaris cultivation technologies have been receiving great interest in recent years.…”

Section: Introductionmentioning

confidence: 99%

Solid state fermentation with Cordyceps militaris SN-18 enhanced antioxidant capacity and DNA damage protective effect of oats (Avena sativa L.)

Xiao

Rui

Xing

et al. 2015

Journal of Functional Foods

View full text Add to dashboard Cite

Effect of Cordyceps militaris extract and active constituents on metabolic parameters of obesity induced by high-fat diet in C58BL/6J mice

Cited by 60 publications

References 22 publications

Preventive Effects of <i>Ophiocordyceps </i><i>s</i><i>inensis </i>Mycelium on High-Fat Diet Induced Lipid Dysregulation and Hepatic Inflammation of Mice

Preventive Effects of <i>Ophiocordyceps </i><i>s</i><i>inensis </i>Mycelium on High-Fat Diet Induced Lipid Dysregulation and Hepatic Inflammation of Mice

Effect of the Capsicoside G‐rich Fraction from Pepper (Capsicum annuum L.) Seeds on High‐fat Diet‐induced Obesity in Mice

Solid state fermentation with Cordyceps militaris SN-18 enhanced antioxidant capacity and DNA damage protective effect of oats (Avena sativa L.)

Contact Info

Product

Resources

About