Effect of Coriander Plants on Human Emotions, Brain Electrophysiology, and Salivary Secretion

Zhang, Wenzhu; Li, Zhaoming; Wang, Lingshan; Liu, Hui; Liu, Hong

doi:10.3390/biology10121283

Cited by 9 publications

(5 citation statements)

References 49 publications

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“…Additionally, positive emotional tears production is related to a series of external secretions pathways, such as salivary secretion, gastric acid secretion and pancreatic secretion. It’s consistent with previous report that the activity of brain electrophysiological and salivary secretion can improve negative emotions of people and reduce amino acids (arginine, proline, histidine, and taurine) concentrations in saliva 26 . In summary, it is evident that secretion of either positive or negative emotional tears involves different biological activities.…”

Section: Discussionsupporting

confidence: 93%

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Non-targeted metabolomics analysis reveals distinct metabolic profiles between positive and negative emotional tears of humans

Liang

Yang³

et al. 2022

Preprint

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BACKGROUND Although the chemical components of basal, reflex, and emotional tears are different, the presence of distinctions in the tears of different emotions is still unknown. The present study aimed to address the biochemical basis behind emotional tears through non-targeted metabolomics analysis between positive and negative emotional tears of humans. METHODS Samples of reflex (C), negative (S), and positive (M) emotional tears were collected from healthy college participants. Untargeted metabolomics was performed to identify the metabolites in the different types of tears. The differentially altered metabolites were screened and assessed using univariate and multivariate analyses. RESULTS The global metabolomics signatures classified the C, S, and M emotional tears. A total of 133 significantly differential metabolites of ESI- mode were identified between negative and positive emotional tears. The top 50 differential metabolites between S and M were highly correlated. The significantly altered pathways included porphyrin & chlorophyll metabolism, bile secretion, biotin metabolism, arginine & proline metabolism and among others. CONCLUSION The metabolic profiles between reflex, positive, and negative emotional tears of humans are distinct. Secretion of positive and negative emotional tears are distinctive biological activities. Therefore, the present study provides a chemical method to detect human emotions which may become a powerful tool for diagnosis of mental disease and identification of fake tears.

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Section: Discussionsupporting

confidence: 93%

“…Besides, positive emotional tears shedding is relevant to arginine and proline metabolism. Previous studies have identified the panel of metabolites associated with depression in animal models and patients 26, 27 . The levels of arginine, proline, taurine, glycine, and alanine are higher in depressed individuals than in healthy ones.…”

Section: Discussionmentioning

confidence: 99%

Non-targeted metabolomics analysis reveals distinct metabolic profiles between positive and negative emotional tears of humans

Liang

Yang³

et al. 2022

Preprint

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“…Positive emotional tears shedding is also associated with arginine and proline metabolism. The panel of metabolites associated with depression in animal models and patients has reported that levels of arginine, proline, taurine, glycine, and alanine are higher in depressed than in healthy individuals [ 26 , 27 ]. Microbial functions and metabolites, including proline, converging in glutamate/GABA metabolism are linked to depression.…”

Section: Discussionmentioning

confidence: 99%

Non-targeted Metabolomics Analysis Reveals Distinct Metabolic Profiles Between Positive and Negative Emotional Tears of Humans: A Preliminary Study

Liang¹,

Wu²,

Yang³

et al. 2023

Cureus

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Background Basal, reflex, and emotional tears differ in chemical components. It is not yet known whether chemical differences exist in tears of different emotions. We investigated the biochemical basis of emotional tears by performing non-targeted metabolomics analyses of positive and negative emotional tears of humans. Methods Samples of reflex, negative, and positive emotional tears were obtained from 12 healthy college participants (11 females and one male). Untargeted metabolomics was performed to identify metabolites in different types of tears. The differentially altered metabolites were screened and assessed using univariate and multivariate analyses. Results The orthogonal partial least squares discriminant analysis model showed that reflex, negative, and positive emotional tears were clearly separated. A total of 133 significantly differentially expressed metabolites of electrospray ionization source (ESI-) mode were identified between negative and positive emotional tears. The top 50 differentially expressed metabolites between negative and positive emotional tears were highly correlated. Pathway analysis revealed that secretion of negative emotional tears was associated with some synapses in the brain, regulation of a series of endocrine hormones, including the estrogen signaling pathway, and inflammation activities, while secretion of positive emotional tears was correlated with biotin and caffeine metabolism. Conclusions It is indicated that metabolic profiles of reflex, positive, and negative emotional tears of humans are distinct, and secretion of the tears involves distinct biological activities. Therefore, we present a chemical method for detecting human emotions, which may become a powerful tool for the diagnosis of mental diseases and the identification of fake tears.

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“…In particular, there are data for α-pinene (T1) and linalool (T11) suggesting their effects on diseases, including stroke, ischemia, neuropathic pain, cognitive impairment (relevant to Alzheimer's disease and aging), anxiety, and depression [41]. Medicinal value in the treatment of anxiety syndromes has also been reported for dl-limonene (T3) and α-terpineol (T16) [94]. For thymol (T23), a potent anti-inflammatory agent, a specific cognitive enhancement activity has also been suggested in a rat model with dementia [95].…”

Section: Vocs Profile Of Honeymentioning

confidence: 99%

Chemical Characterization and Biological Properties of Leguminous Honey

Fratianni,

Amato,

Ombra

et al. 2024

Antioxidants

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Honey can beneficially act against different human diseases, helping our body to improve its health. The aim of the present study was first to increase knowledge of some biochemical characteristics (amount and composition of polyphenols and volatile organic compounds, vitamin C content) of five Italian legume honeys (alfalfa, astragalus, carob, indigo, and sainfoin). Furthermore, we evaluated their potential health properties by studying their antioxidant and in vitro anti-inflammatory activities and in vitro inhibitory effects on three enzymes involved in neurodegenerative diseases (acetylcholinesterase, butyrylcholinesterase, and tyrosinase). Alfalfa honey showed the highest total polyphenol content (TPC) (408 μg g−1 of product). Indigo honey showed the lowest TPC (110 μg g−1 of product). The antioxidant activity was noteworthy, especially in the case of sainfoin honey (IC50 = 6.08 mg), which also exhibited excellent inhibitory action against butyrylcholinesterase (74%). Finally, the correlation between the biochemical and functional results allowed us to identify classes of molecules, or even single molecules, present in these five honeys, which are capable of influencing the properties indicated above.

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Effect of Coriander Plants on Human Emotions, Brain Electrophysiology, and Salivary Secretion

Cited by 9 publications

References 49 publications

Non-targeted metabolomics analysis reveals distinct metabolic profiles between positive and negative emotional tears of humans

Non-targeted metabolomics analysis reveals distinct metabolic profiles between positive and negative emotional tears of humans

Non-targeted Metabolomics Analysis Reveals Distinct Metabolic Profiles Between Positive and Negative Emotional Tears of Humans: A Preliminary Study

Chemical Characterization and Biological Properties of Leguminous Honey

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