Effect of Cornus Officinalis on Receptor Activator of Nuclear Factor-kappaB Ligand (RANKL)-induced Osteoclast Differentiation

Kim, Jung Young; Kim, Yun-Kyung; Choi, Min Kyu; Oh, Jae‐Min; Kwak, Han Bok; Kim, Jeong-Joong

doi:10.11005/jbm.2012.19.2.121

Cited by 32 publications

(28 citation statements)

References 20 publications

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“…Isolated cells were incubated with RANKL and M-CSF for osteoclast differentiation and co-treated with single or three different ratios of CO and AJ mixtures (9:1, 8:2, and 7:3) for 6 days. As a result, both CO and AJ (10 and 50 μg/mL) extract in our study did not affect cellular proliferation ( Supplementary Figure S3 ), but inhibited TRAP activity ( Supplementary Figure S4 ), as previously described in the literature [ 18 , 32 ]. In addition, mixtures of CO and AJ did not show toxic effect to osteoclasts during the differentiation period ( Figure 3 B).…”

Section: Resultssupporting

confidence: 87%

“…Cornus officinalis (CO) and Achyranthes japonica (AJ) have traditionally been used as herbal medicines in East Asia for their anti-oxidative, anti-inflammatory, and anti-cancer effects [ 15 , 16 , 17 ]. Previous studies have reported that CO inhibited osteoclast differentiation and promoted osteoblast differentiation, and AJ exhibited osteoprotective effects in ovariectomized (OVX) mice [ 18 , 19 , 20 , 21 ]. Although the individual anti-osteoporotic effects of Cornus officinalis (CO) and Achyranthes japonica (AJ) have been demonstrated, the synergistic effects of combined CO and AJ on osteoporosis have not been reported.…”

Section: Introductionmentioning

confidence: 99%

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Anti-Osteoporotic Effects of the Herbal Mixture of Cornus officinalis and Achyranthes japonica In Vitro and In Vivo

Park

Lee

Kim

et al. 2020

Plants

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Osteoporosis is a porous bone disease caused by bone density loss, which increases the risk of fractures. Cornus officinalis (CO) and Achyranthes japonica (AJ) have been used as traditional herbal medicine for various disorders in East Asia. Although the anti-osteoporotic effects of single extract of CO and AJ have already been reported, the synergistic effect of a combined mixture has not been studied. In this study, we investigated the effects of a CO and AJ herbal mixture on osteoporosis in in vitro and in vivo models. The results demonstrate that treatment with the CO and AJ mixture significantly promoted osteoblast differentiation of MC3T3-E1 mouse preosteoblasts through the upregulation of osteoblastic differentiation-associated genes such as alkaline phosphatase (Alpl), runt-related transcription factor 2 (Runx2), and bone gamma-carboxyglutamic acid-containing protein (Bglap), while the mixture significantly inhibited differentiation of osteoclasts isolated from primary-cultured mouse monocytes. In addition, oral administration of CO and AJ mixture significantly prevented bone mineral density loss and trabecular bone structures in an ovariectomy-induced osteoporotic mouse model. These results suggest that the combination treatment of CO and AJ mixture might be a beneficial therapy for osteoporosis.

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Section: Resultssupporting

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Anti-Osteoporotic Effects of the Herbal Mixture of Cornus officinalis and Achyranthes japonica In Vitro and In Vivo

Park

Lee

Kim

et al. 2020

Plants

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“…In the same way, the protein expression of c-Fos and NFATc1 is also suppressed as well as the RANKL-induced degradation of IκB kinase (Kim J. Y. et al, 2012). Morroniside ( 8 ), one the main constituent of extracts from C. officinalis fruits, has been studied on osteoarthritis in human chondrocytes.…”

Section: Unique Biological and Pharmacological Activities Of C Mas Amentioning

confidence: 95%

Cornus mas and Cornus Officinalis—Analogies and Differences of Two Medicinal Plants Traditionally Used

Czerwińska

Melzig

2018

Front. Pharmacol.

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Among 65 species belonging to the genus Cornus only two, Cornus mas L. and Cornus officinalis Sieb. et Zucc. (Cornaceae), have been traditionally used since ancient times. Cornus mas (cornelian cherry) is native to southern Europe and southwest Asia, whereas C. officinalis (Asiatic dogwood, cornel dogwood) is a deciduous tree distributed in eastern Asia, mainly in China, as well as Korea and Japan. Based on the different geographic distribution of the closely related species but clearly distinct taxa, the ethnopharmacological use of C. mas and C. officinalis seems to be independently originated. Many reports on the quality of C. mas fruits were performed due to their value as edible fruits, and few reports compared their physicochemical properties with other edible fruits. However, the detailed phytochemical profiles of C. mas and C. officinalis, in particular fruits, have never been compared. The aim of this review was highlighting the similarities and differences of phytochemicals found in fruits of C. mas and C. officinalis in relation to their biological effects as well as compare the therapeutic use of fruits from both traditional species. The fruits of C. mas and C. officinalis are characterized by the presence of secondary metabolites, in particular iridoids, anthocyanins, phenolic acids and flavonoids. However, much more not widely known iridoids, such as morroniside, as well as tannins were detected particularly in fruits of C. officinalis. The referred studies of biological activity of both species indicate their antidiabetic and hepatoprotective properties. Based on the available reports antihyperlipidemic and anticoagulant activity seems to be unique for extracts of C. mas fruits, whereas antiosteoporotic and immunomodulatory activities were assigned to preparations of C. officinalis fruits. In conclusion, the comparison of phytochemical composition of fruits from both species revealed a wide range of similarities as well as some constituents unique for cornelian cherry or Asiatic dogwood. Thus, these phytochemicals are considered the important factor determining the biological activity and justifying the use of C. mas and C. officinalis in the traditional European and Asiatic medicine.

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“…Reduce protein and mRNA levels of c-Fos, NFATc1, OSCAR, and TRAP. Inhibit phosphorylation of p-38 and c-JNK and degradation of I-κB [ 57 ] Promoting melanogenesis activity Methanol extract Melan-a cell lines Increase the production and activity of tyrosinase. Increase MITF-M mRNA level and TRP-1&2 production [ 58 ] Immunomodulatory activity Aqueous extract C57BL/6 mice are transplanted with a skin graft from Balb/C donors Prolong skin allograft survival.…”

Section: Pharmacological Activitiesmentioning

confidence: 99%

“…Firstly, sweroside (at 7.5 µg mL −1 ) for 1 week significantly promoted the proliferation and differentiation of osteoblasts via the regulation of osteocalcin [ 56 ]. Also, CF extract (at 0–100 µg mL −1 ) for 4 days significantly inhibited osteoclast differentiation in a dose-dependent manner via the inhibition of the signaling cascades NF-κB/c-Fos/NFATc1 to improve osteoporosis [ 57 ]. Secondly, CF methanol extract (at 3.125–12.5 µg mL −1 ) for 3 days significantly up-regulated synthesis and activity of tyrosinase, raised TRP-1&2 translation associating with increasing transcription of MITF-M, finally promoted melanogenesis by 36.1% [ 58 ].…”

Section: Pharmacological Activitiesmentioning

confidence: 99%

Corni Fructus: a review of chemical constituents and pharmacological activities

et al. 2018

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Cornus officinalis Sieb. et Zucc. is part of the genus Cornus of the family Cornaceae. Ripening and dry fruits (Corni Fructus) are recognized as an essential herb medicine in the traditional Chinese medicine (TCM) and have been widely used for over 2000 years. This review provides a comprehensive summary of Corni Fructus (CF), including the botany, phytochemistry, traditional use, and current pharmacological activities. According to the basic theory of TCM, CF usually participates in various Chinese medicinal formulae to exert the essential roles in replenishing liver and kidney, arresting seminal emission and sweat. Based on modern pharmacological studies, about 90 compounds have been isolated and identified from CF. In vivo and in vitro experimental studies indicate that CF exhibits extensive pharmacological activities including hypoglycemic, antioxidant, anti-inflammatory, anticancer, neuroprotective, hepatoprotective, and nephroprotective activities. However, only about 18% of chemical constituents in CF were tested. It means the potential pharmacological activities and clinical values of CF need to be further investigated.

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Effect of Cornus Officinalis on Receptor Activator of Nuclear Factor-kappaB Ligand (RANKL)-induced Osteoclast Differentiation

Cited by 32 publications

References 20 publications

Anti-Osteoporotic Effects of the Herbal Mixture of Cornus officinalis and Achyranthes japonica In Vitro and In Vivo

Anti-Osteoporotic Effects of the Herbal Mixture of Cornus officinalis and Achyranthes japonica In Vitro and In Vivo

Cornus mas and Cornus Officinalis—Analogies and Differences of Two Medicinal Plants Traditionally Used

Corni Fructus: a review of chemical constituents and pharmacological activities

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