Effect of creatine phosphate sodium on bispectral index and recovery quality during the general anaesthesia emergence period in elderly patients: A randomized, double-blind, placebo-controlled trial

Abstract

ObjectiveTo evaluate the effect of creatine phosphate sodium on bispectral index (BIS) and recovery quality during the general anaesthesia emergence period in elderly patients.MethodsThis randomized, double-blind, placebo-controlled study enrolled patients undergoing transabdominal cholecystectomy under general anaesthesia. Patients were randomly assigned to receive either creatine phosphate sodium (1.0 g/100 ml 0.9% saline; group P) or 100 ml 0.9% saline (group C) over 30 minutes during surgical incision. The BIS values were recorded at anaesthesia induction (T0), skin incision (T1), cutting the gallbladder (T2), suturing the peritoneum (T3), skin closure (T4), sputum suction (T5), extubation (T6) and 1 min (T7), 5 min (T8), 10 min (T9), and 15 min (T10) after extubation. The anaesthesia duration, operation time, waking time, extubation time, consciousness recovery time, time in the postanaesthesia care unit (PACU), and the Steward recovery scores at T7, T8, T9 and T10 were recorded.ResultsA total of 120 elderly patients were randomized equally to the two groups. Compared with group C, the BIS values were significantly higher in group P at T5, T6, T7 and T8; and the Steward recovery scores at T7 and T8 were significantly higher in group P. The waking time, extubation time, consciousness recovery time and time in the PACU were significantly shorter in group P compared with group C.ConclusionCreatine phosphate sodium administered during transabdominal cholecystectomy can improve BIS values and recovery following general anaesthesia in elderly patients.

Cardioprotection with the use of exogenous phosphocreatine in general surgery and critical conditions. Review

“…В 2018 г. Wei Wang с соавт. опубликовали результаты рандомизированного двойного слепого плацебо-контролируемого исследования с участием пожилых пациентов от 65 до 80 лет, которым выполнялась трансабдоминальная холецистэктомия под общим наркозом [52]. 120 пациентов были случайным образом распределены либо в группу терапии ФК (1,0 г растворенного в 100 мл 0,9 % физиологического раствора), либо в группу контроля, в которой пациенты получали 100 мл 0,9 % физиологического раствора без ФК.…”