Effect of crocin extracted from saffron on pro-oxidant–anti-oxidant balance in subjects with metabolic syndrome: A randomized, placebo-controlled clinical trial

Nikbakht-Jam, Irandokht; Khademi, Mohammad; Nosrati, Mina; Eslami, Saeid; Foroutan-Tanha, Mojtaba; Sahebkar, Amirhossein; Tavalaie, Shima; Ghayour‐Mobarhan, Majid; Ferns, Gordon A.; Hadizadeh, Farzin; Tabassi, Sayyed Abolghasem Sajadi; Mohajeri, Seyed Ahmad; Emamian, Marzieh

doi:10.1016/j.eujim.2015.12.008

Cited by 59 publications

(62 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…and (c) studies that evaluated the effect of saffron in combination with other foods and supplements (n = 2). Fourteen articles (18 arms) representing 788 participants (Abedimanesh et al, 2017;Azimi, Ghiasvand, Feizi, Hariri, & Abbasi, 2014;Fadai et al, 2014;Gout et al, 2010;Jafarnia et al, 2017;Javandoost et al, 2017;Kermani, Kazemi, et al, 2017;Kermani, Zebarjadi, et al, 2017;Mansoori et al, 2011;Milajerdi et al, 2018;Modaghegh, Shahabian, Esmaeili, Rajbai, & Hosseinzadeh, 2008;Mohamadpour, Ayati, Parizadeh, Rajbai, & Hosseinzadeh, 2013;Nikbakht-Jam et al, 2016;Sepahi et al, 2018) met our inclusion criteria and were included in the meta-analysis.…”

Section: Resultsmentioning

confidence: 99%

“…Characteristics of eligible studies are shown in Table 1. Most studies were conducted in Iran (Abedimanesh et al, 2017;Azimi et al, 2014;Fadai et al, 2014;Jafarnia et al, 2017;Javandoost et al, 2017;Kermani, Kazemi, et al, 2017;Kermani, Zebarjadi, et al, 2017;Mansoori et al, 2011;Milajerdi et al, 2018;Modaghegh et al, 2008;Mohamadpour et al, 2013;Nikbakht-Jam et al, 2016;Sepahi et al, 2018) and one in France (Gout et al, 2010). The sample size of the included studies ranged from 20 to 81 individuals with mean age of 43 years in intervention groups and 45 years in control groups.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…The results of the quality assessment of included studies are provided in Table 2. Four arms have fair quality (Modaghegh et al, 2008;Mohamadpour et al, 2013;Nikbakht-Jam et al, 2016), one has poor quality , and 13 have good quality (Abedimanesh et al, 2017;Fadai et al, 2014;Gout et al, 2010;Jafarnia et al, 2017;Javandoost et al, 2017;Kermani, Kazemi, et al, 2017;Kermani, Zebarjadi, et al, 2017;Mansoori et al, 2011;Milajerdi et al, 2018;Sepahi et al, 2018). Most studies demonstrated adequate quality for key factors.…”

Section: Quality Assessmentmentioning

confidence: 99%

See 2 more Smart Citations

The effect of saffron on weight and lipid profile: A systematic review, meta‐analysis, and dose–response of randomized clinical trials

Rahmani

Manzari

Thompson

et al. 2019

Phytotherapy Research

View full text Add to dashboard Cite

Plant derivatives such as carotenoids and phytosterols enrich foods have been shown to reduce plasma triglyceride (TG), low‐density lipoprotein (LDL) cholesterol, and cholesterol concentrations. The aim of this systematic review and meta‐analyses study was to investigate the effects of saffron on lipid profiles, reported in randomized controlled trials (RCTs). We performed a systematic electronic search in PubMed/MEDLINE, Cochrane, and SCOPUS to identify RCTs and screening of relevant articles references up to October 12, 2018. There were no language restrictions. We performed this systematic review and meta‐analysis according to the Preferred Items for Reporting of Systematic Reviews and Meta‐Analyses guidelines. We identified and analyzed 14 eligible studies in this meta‐analysis. Our study found a significant reduction in cholesterol and TG following saffron intervention (weighted mean difference [WMD]: −6.36 mg/dl, 95% confidence interval, CI, [−10.58, −2.18] and WMD: −5.37 mg/dl, 95% CI [−10.25, −0.48], respectively). There was no significant effect on weight and LDL concentration. A meta‐regression analysis showed that long‐term saffron intervention can increase the high‐density lipoprotein (HDL) levels. In conclusions, our study findings indicate some benefits of saffron on cholesterol, HDL, and TG compared with placebo. However, we recommend the conduct of adequately powered, high‐quality RCTs with short‐ and long‐term follow‐up, evaluating relevant clinical outcomes to allow for making definitive recommendations.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

Section: Quality Assessmentmentioning

confidence: 99%

See 1 more Smart Citation

The effect of saffron on weight and lipid profile: A systematic review, meta‐analysis, and dose–response of randomized clinical trials

Rahmani

Manzari

Thompson

et al. 2019

Phytotherapy Research

View full text Add to dashboard Cite

show abstract

“…Crocin and crocetin are the two main carotenoids of saffron. Numerous studies on the pharmacological effects of Crocin have confirmed antidepressant, 9 antiatherosclerotic, 10 anti-platelet aggregation, 11 renoprotective, 12 anti-tumor 13 and anti-oxidant 14,15 properties. Crocin has also been reported to have protective effects against gentamicininduced nephrotoxicity.…”

Section: Introductionmentioning

confidence: 99%

Therapeutic effects of Crocin in autoimmune diseases: A review

Korani

Sathyapalan

et al. 2019

BioFactors

View full text Add to dashboard Cite

The immune system when acts against selfmolecules results in an imbalance in immunologic tolerance leading to the development of several autoimmune diseases (ADs) such as rheumatoid arthritis, asthma, ulcerative colitis, type 1 diabetes, and multiple sclerosis. Improved recognition of the mechanisms of ADs has led to the advancement of the management of these diseases. The principal mediators of ADs are inflammatory molecules. The herbal medicines due to their antioxidant and antiinflammatory properties have an important role in the management of ADs. Crocin is the principal chemical component extracted from saffron, which is a medicinal plant. This review focuses on the therapeutic effects of Crocin in various ADs.

show abstract

“…Crocin, which is responsible for the color of saffron, is the most abundant compound in saffron [2]. It has been known that saffron is useful to cure various illnesses, for example, neuronal diseases like depressive disorder [3]; it is also useful for preventing diabetes complication [4], metabolic syndrome [5], and cancer [6] in both clinical trials and animal model studies. It also has various biological activities extensively reviewed by Bathaie's [7] and Hosseinzadeh's research groups [8].…”

Section: Introductionmentioning

confidence: 99%

Homogenate Extraction of Crocins from Saffron Optimized by Response Surface Methodology

Tong

Jiang

Guo

et al. 2018

Journal of Chemistry

View full text Add to dashboard Cite

Saffron, which has many kinds of biological activities, has been widely used in medicine, cosmetics, food, and other fields of health promotion industries. Crocins are the main component of saffron (Crocus sativus L.). At present, most of the extraction methods for crocins require long time or special instruments to complete the process and some of them are not suitable for industrial production at present. In this article, homogenate extraction technology which is a convenient and efficient method was developed for crocins extraction from saffron. Firstly, the influences of extraction voltage, extraction time, ethanol concentration, and temperature on crocins yield were studied by single factor experiments; and then response surface methodology (RSM) was used to optimize levels of four variables based on the result of single factor experiments. Results showed that the optimum extraction process conditions for crocins were as follows: extraction voltage, 110 V; ethanol concentration, 70%; extraction temperature, 57 ∘ C; and extraction time, 40 s. Based on these conditions, the extraction yield of crocins can reach 22.76% which is higher than ultrasonic extraction method. Therefore, homogenate extraction is an effective way to extract crocins from saffron with higher extraction yield and shorter extraction time.

show abstract

Effect of crocin extracted from saffron on pro-oxidant–anti-oxidant balance in subjects with metabolic syndrome: A randomized, placebo-controlled clinical trial

Cited by 59 publications

References 23 publications

The effect of saffron on weight and lipid profile: A systematic review, meta‐analysis, and dose–response of randomized clinical trials

The effect of saffron on weight and lipid profile: A systematic review, meta‐analysis, and dose–response of randomized clinical trials

Therapeutic effects of Crocin in autoimmune diseases: A review

Homogenate Extraction of Crocins from Saffron Optimized by Response Surface Methodology

Contact Info

Product

Resources

About