Effect of crosslinked condition on characteristics of chitosan/tripolyphosphate/genipin beads and their application in the selective adsorption of phytic acid from soybean whey

Design of chitospheres loaded with pristine polymer particles for extended drug delivery via polyelectrolyte complexation and particulate leaching

“…These multiparticulate spherical matrices (Pasparakis and Bouropoulos, 2006;Srinatha et al, 2008;Kotadiya et al, 2009;Yang et al, 2011;Ko et al, 2002;Lin et al, 2005;Harris et al, 2010;Jonassen et al, 2012;Rampino et al, 2013) comprise chitosan alone or blended with other property-modifying natural or synthetic polymers that have been widely used for the oral delivery of therapeutic agents and for long-term sustained delivery of proteins, peptides and other essential growth factors for tissue regeneration applications and gene delivery technologies (Anal et al, 2003;Vimal et al, 2013).…”

“…Strategies aimed at improving mechanical strength of and more particularly the controlled release of drug from chitosan beads includes the use of genipin as a covalent crosslinker as opposed to ionic crosslinkers. Yang et al (2011) investigated the mechanical properties of STPP/ genipin co-crosslinked chitosan beads whereas Harris et al (2010) employed a series of chitosan hydrochloride genipin crosslinking reactions for the controlled release of drugs and proteins. Another widespread method employed for enhancing the drug delivery properties of chitosan beads involve the polyelectrolyte complexation of chitosan with anionic polymers either via blending of polymers prior to bead formation or coating of the beads employing a series of layering techniques using mainly alginates (Wang et al, 2010;Gong et al, 2011;Zhang et al, 2011;Torelli-Souza et al, 2012;Zhou et al, 2013) and pectins (Maestrelli et al, 2012;Ribeiro et al, 2014).…”

Production and Characterization of Chitosan–Polyanion Nanoparticles by Polyelectrolyte Complexation Assisted by High-Intensity Sonication for the Modified Release of Methotrexate

“…However, one of the main problems associated with the development of this type of NP is related to the type and concentration of the crosslinking agent [19,20]. Most of the crosslinking agents used for the production of chitosan NPs are molecular polyanions, such as tripolyphosphate [21][22][23], phytic acid [24,25] and macromolecular polyanions, such as poly(lactic-co-glycolic acid) [26], sodium alginate [27][28][29], and gum arabic [30][31][32][33][34]. To date, there are few reports dealing with the creation of chitosan nanoparticles with anionic polymers derived from maleic anhydrides, which are biocompatible and water soluble, and have a well-defined structure and hydrophilic or hydrophobic character that can be feasibly varied, allowing the encapsulation of different compounds of pharmaceutical interest [35].…”

Improving the Color Stability of Naturally Colored Silk by Cross-Linking the Sericin with Phytic Acid

“…Due to the six strongly electronegative phosphate moieties in its structure, phytic acid can interact with amino group-containing polymers via electrostatic forces to form an ionic crosslinked network. Phytic acid shows a strong ability to chelate multivalent cations, such as Fe 3+ , Ca 2+ , and cationic polymers [16]. Therefore, it is employed to cross-link chitosan and gelatin materials for biomedical usage [15][16][17].…”