Effect of Danggui Buxue Tang on immune-mediated aplastic anemia bone marrow proliferation mice

Xj, Yang; Huang, Chonggang; Du, Shouying; Yang, Shiliang; Zhang, Xue; Xian-QinLuo,; Xu, Jiahong

doi:10.1016/j.phymed.2013.10.018

Cited by 27 publications

(18 citation statements)

References 20 publications

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“…The most popular formulation is Danggui Buxue Tang (DBT) composed of Astragalus and Angelica at a 5 : 1 ratio, which is mainly used to treat anemia due to various causes via promoting hematopoiesis. 1) In recent years, studies have shown that DBT also has other pharmacological effects, such as enhancing immunity, 2) antagonizing diabetic nephropathy, 3) cardiovascular protection, 4) anti-fibrosis, 5,6) estrogen-like effect, 7,8) among others. Concerning the hematopoietic function of the AstragalusAngelica combination, most studies have revealed that Astragalus mixed with Angelica at 5 : 1 can strongly promote hematopoiesis.…”

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confidence: 99%

Effects of Astragalus Combined with Angelica on Bone Marrow Hematopoiesis Suppression Induced by Cyclophosphamide in Mice

Tang

Chen

et al. 2017

Biological & Pharmaceutical Bulletin

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Danggui Buxue Tang (DBT), a combination of Astragalus and Angelica at a 5 : 1 ratio, mainly promotes hematopoiesis. However, in the clinic, the combination ratio of Astragalus and Angelica to treat low hematopoietic function is not an absolute 5 : 1 ratio, suggesting that the herbs may promote hematopoiesis better after being combined at a certain range of ratios. The objective of this study is to investigate the effect of different ratio combinations of Astragalus and Angelica on bone marrow hematopoiesis suppression induced by cyclophosphamide (CTX) and to probe the interaction and mechanism of Astragalus combined with Angelica in promoting hematopoiesis. Following establishment of the model, mice were administered with Astragalus (6.00 g·kg 1

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mentioning

confidence: 99%

Effects of Astragalus Combined with Angelica on Bone Marrow Hematopoiesis Suppression Induced by Cyclophosphamide in Mice

Tang

Chen

et al. 2017

Biological & Pharmaceutical Bulletin

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“…Danggui Buxue Decoction could not only withstand significantly decreation of blood cells by immune-mediated, but also stimulate on the growth of bone marrow colony cell and increase the weight of hemopoietic progenitor of bone marrow (17). In animal experiments, the ability of Danggui Buxue Decoction was to promote hematopoiesis and proliferative actions on hematopoietic progenitor cells, researchers have reported constituents related to various Danggui Buxue Decoction activities (18).…”

Section: Discussionmentioning

confidence: 99%

Efficacy and safety of Danggui Buxue Decoction in combination with western medicine treatment of anemia for renal anemia: a systematic review and meta-analysis

Zhao

Zhang

et al. 2017

Ann. Transl. Med.

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Conclusions: Danggui Buxue Decoction in combination with conventional western medicine (CWM) for renal anemia might be superior to CWM alone and there was no adverse event in the experimental group, it might be more effective when the ratio of Radix Astragali to Radix Angelicae Sinensis was 5:1. However, the quality of included studies was not high, and less attention was paid to the safety, high quality randomized controlled trials are needed to further confirm the findings.

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“…Ke et al also showed that DBD inhibited HG-induced GMCs proliferation and reduced the expression of laminin and type IV collagen in GMCs [28]. Interestingly, DBD was previously reported to enhance proliferation of osteoblasts [29], T-lymphocytes [30], and bone marrow cells [31]. The discrepancy between the effects of DBD on cell proliferation may be due to the differences in culture conditions and cell types.…”

Section: Discussionmentioning

confidence: 99%

Effects of Dangguibuxue decoction on rat glomerular mesangial cells cultured under high glucose conditions

Ren

Zhang

Wang

et al. 2017

BMC Complement Altern Med

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BackgroundDysfunction of glomerular mesangial cells (GMCs) plays an important role in pathogenesis of diabetic nephropathy. Here, we investigated the effects of Dangguibuxue decoction (DBD), an herbal traditional Chinese medicinal (TCM) formula composed of Astragali Radix and Angelicae Sinensis Radix, on GMC proliferation and fibrogenesis under high-glucose (HG) conditions.MethodsSixty male Sprague Dawley rats were divided into 5 groups and administered intragastric 0.9% saline, low concentration DBD (DBD-L, 1.75 g/kg/d), middle concentration DBD (DBD-M, 3.5 g/kg/d), high concentration DBD (DBD-H, 7.0 g/kg/d) and gliclazide (GL, 2 mg/kg/d), respectively, for 1 week, and then their sera were obtained. Rat mesangial cells (HBZY-1 cells) were treated with these sera under HG condition (30 mmol/L).ResultsThe proliferation of GMCs under HG conditions was significantly greater than that under normal glucose condition. Low concentration DBD (DBD-L) inhibited proliferation of GMCs after 72-h incubation (P < 0.01), while high concentration DBD (DBD-H) inhibited GMCs proliferation at 24, 48 and 72 time points (P < 0.01). There was no significant difference between the inhibitory effect of DBD-H and GL sera on GMC proliferation (P > 0.05). Furthermore, all concentrations of DBD (DBD-L, DBD-M and DBD-H) significantly decreased the protein expression of α-SMA(α-smooth muscle actin) (P < 0.01), an indicator of interstitial fibrosis of GMCs. Finally, DBD-L, DBD-M, DBD-H sera obviously inhibited the increase of HYP (hydroxyproline)secretion under HG condition (P < 0.01).ConclusionOur results demonstrate an inhibitory effect of DBD extract on proliferation and fibrogenesis of GMCs under HG conditions. The potential role of DBD in the treatment of diabetic neuropathy merits further investigation.

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Effect of Danggui Buxue Tang on immune-mediated aplastic anemia bone marrow proliferation mice

Cited by 27 publications

References 20 publications

Effects of <i>Astragalus</i> Combined with <i>Angelica</i> on Bone Marrow Hematopoiesis Suppression Induced by Cyclophosphamide in Mice

Effects of <i>Astragalus</i> Combined with <i>Angelica</i> on Bone Marrow Hematopoiesis Suppression Induced by Cyclophosphamide in Mice

Efficacy and safety of Danggui Buxue Decoction in combination with western medicine treatment of anemia for renal anemia: a systematic review and meta-analysis

Effects of Dangguibuxue decoction on rat glomerular mesangial cells cultured under high glucose conditions

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