2023
DOI: 10.3389/fmed.2023.1259182
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Effect of Danhong injection on heart failure in rats evaluated by metabolomics

Lin Li,
Senjie Zhong,
Jiahao Ye
et al.

Abstract: BackgroundHeart failure (HF) is characterized by reduced ventricular filling or ejection function due to organic or non-organic cardiovascular diseases. Danhong injection (DHI) is a medicinal material used clinically to treat HF for many years in China. Although prior research has shown that Danhong injection can improve cardiac function and structure, the biological mechanism has yet to be determined.MethodsSerum metabolic analysis was conducted via ultra-high-performance liquid chromatography-quadrupole time… Show more

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Cited by 3 publications
(6 citation statements)
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“…For the calculation of the Left Ventricular Ejection Fraction (LVEF)and Left Ventricular Fractional Shortening (LVFS), the computer software (VINNO6, Suzhou VINNO Technology Co., Ltd., Suzhou, China) was used ( Li et al, 2023 ).…”
Section: Methodsmentioning
confidence: 99%
“…For the calculation of the Left Ventricular Ejection Fraction (LVEF)and Left Ventricular Fractional Shortening (LVFS), the computer software (VINNO6, Suzhou VINNO Technology Co., Ltd., Suzhou, China) was used ( Li et al, 2023 ).…”
Section: Methodsmentioning
confidence: 99%
“…Gut microbiota can affect an organism by modulating the host metabolic products or through its metabolic products. In a metabolomics study by Li et al (2023), metabolic imbalances such as disturbances in the metabolism of amino acids, lipids, and glucose, were established to be associated with heart failure (Li et al, 2023). LC-MS analysis was conducted to investigate the influence of gut microbiota on the host metabolism of the ISOinduced HF rat model.…”
Section: Discussionmentioning
confidence: 99%
“…For the calculation of the Left Ventricular Ejection Fraction (LVEF)and Left Ventricular Fractional Shortening (LVFS), the computer software (VINNO6, Suzhou VINNO Technology Co., Ltd., Suzhou, China) was used (Li et al, 2023).…”
Section: Echocardiographymentioning
confidence: 99%
“…Gut microbiota can affect an organism by modulating the host metabolic products or through its metabolic products. In a metabolomics study by Li et al (2023), metabolic imbalances such as disturbances in the metabolism of amino acids, lipids, and glucose, were established to be associated with heart failure (Li et al, 2023). LC-MS analysis was conducted to investigate the influence of gut microbiota on the host metabolism of the ISOinduced HF rat model.…”
Section: Discussionmentioning
confidence: 99%
“…For the calculation of the Left Ventricular Ejection Fraction (LVEF)and Left Ventricular Fractional Shortening (LVFS), the computer software (VINNO6, Suzhou VINNO Technology Co., Ltd., Suzhou, China) was used (Li et al, 2023).…”
Section: Echocardiographymentioning
confidence: 99%