Effect of Deep Brain Stimulation of the Globus Pallidus Internus on Quality of Life in Young Patients with Dyskinetic Cerebral Palsy (STIM-CP): a Prospective Single-Arm Multicenter Trial with a Double-Blind Cross-Over at 12-Months Follow-up

Koy, Anne; Kühn, Andrea A.; Riesen, Anne van; Huebl, Julius; Korinthenberg, Rudolf; Coenen, Volker A.; Krauss, Joachim K.; Wloch, Andreas; Lorenz, Delia; Häussler, Martin; Schnitzler, Alfons; Vesper, Jan; Alesch, François; Lehmacher, Walter; Mueller, Joerg; Borck, Guntram; Witt, Karsten; Bäumer, Tobias; Berweck, Steffen; Schröder, Sebastian; Voges, Jürgen; Langenohl, Reinhild Prinz; Vandewalle, V.; Hellmich, Martin; Timmermann, Lars; investigators, STIM CP

doi:10.4172/2167-0870.1000317

Cited by 3 publications

(6 citation statements)

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“…Further, the first prospective, multicenter trial with planned double‐blind crossover in children and young people with cerebral palsy is underway. In addition to clinical severity, this study will provide important information pertaining to alternative outcome measures, which will help guide selection of surgical candidates …”

Section: Discussionmentioning

confidence: 99%

“…In addition to clinical severity, this study will provide important information pertaining to alternative outcome measures, which will help guide selection of surgical candidates. 41 Overall, findings derived from our systematic review are restricted by inherent limitations of meta-analysis. 42,43 First, although an exhaustive search strategy was used, it is possible that some studies were not identified because of errors in abstract screening or indexing.…”

Section: Strength and Limitationsmentioning

confidence: 99%

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Deep brain stimulation for pediatric dystonia: a meta‐analysis with individual participant data

Elkaim

Alotaibi

Sigal

et al. 2018

Develop Med Child Neuro

107

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Aim We performed a meta‐analysis with individual participant data of deep brain stimulation (DBS) for dystonia in children and young people. Method Three databases (PubMed, Embase, and Web of Science) were queried from January 1999 to August 2017 with no language restrictions to identify case studies and cohort studies reporting on pediatric patients (age ≤21y) with dystonia. The primary outcomes were changes in Burke‐Fahn‐Marsden (BFM) or Barry‐Albright Dystonia Scale scores. A mixed‐effects regression was used to identify associations between clinical covariates and outcomes. Results Of 2509 citations reviewed, 72 articles (321 children) were eligible. At last follow‐up (median 12mo, 25th centile=9.0; 75th centile=32.2), 277 (86.3%) patients showed improvement in dystonia, while 66.1 percent showed clinically significant (>20%) BFM Dystonia Rating Scale‐motor improvement. On multivariable hierarchical regression, older age at dystonia onset, inherited dystonia without nervous system pathology and idiopathic dystonia (vs inherited with nervous system pathology or acquired dystonia), and truncal involvement indicated a better outcome (p<0.05). Interpretation The data suggest that DBS is effective and should be considered in selected children with inherited or idiopathic dystonia. What this paper adds Deep brain stimulation is effective in selected children with inherited or idiopathic dystonia.

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Section: Discussionmentioning

confidence: 99%

Section: Strength and Limitationsmentioning

confidence: 99%

Deep brain stimulation for pediatric dystonia: a meta‐analysis with individual participant data

Elkaim

Alotaibi

Sigal

et al. 2018

Develop Med Child Neuro

107

View full text Add to dashboard Cite

show abstract

“…STIM‐CP is a multicenter, single‐arm, pre‐post trial using a within‐patient control to document patient outcomes for bilateral GPi‐DBS in the treatment of DCP for 12 months 9 …”

Section: Methodsmentioning

confidence: 99%

“…STIM-CP is a multicenter, single-arm, pre-post trial using a within-patient control to document patient outcomes for bilateral GPi-DBS in the treatment of DCP for 12 months. 9 After assessment of primary and secondary outcome parameters under continuous therapeutic stimulation for 12 months, an additional randomized, doubleblind, crossover phase was implemented to detect immediate, even subtle stimulation effects on dystonia and choreo-athetosis that might have been missed during the initial 12-month follow-up (Fig. 1).…”

Section: Methodsmentioning

confidence: 99%

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Quality of Life After Deep Brain Stimulation of Pediatric Patients with Dyskinetic Cerebral Palsy: A Prospective, Single‐Arm, Multicenter Study with a Subsequent Randomized Double‐Blind Crossover (STIM‐CP)

et al. 2021

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Long‐Term Follow‐Up of Pediatric Patients with Dyskinetic Cerebral Palsy and Deep Brain Stimulation

Koy,

Kühn,

Schiller

et al. 2023

Movement Disorders

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BackgroundDeep brain stimulation (DBS) has been increasingly used in the management of dyskinetic cerebral palsy (DCP). Data on long‐term effects and the safety profile are rare.ObjectivesWe assessed the efficacy and safety of pallidal DBS in pediatric patients with DCP.MethodsThe STIM‐CP trial was a prospective, single‐arm, multicenter study in which patients from the parental trial agreed to be followed‐up for up to 36 months. Assessments included motor and non‐motor domains.ResultsOf the 16 patients included initially, 14 (mean inclusion age 14 years) were assessed. There was a significant change in the (blinded) ratings of the total Dyskinesia Impairment Scale at 36 months. Twelve serious adverse events (possibly) related to treatment were documented.ConclusionDBS significantly improved dyskinesia, but other outcome parameters did not change significantly. Investigations of larger homogeneous cohorts are needed to further ascertain the impact of DBS and guide treatment decisions in DCP. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

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Effect of Deep Brain Stimulation of the Globus Pallidus Internus on Quality of Life in Young Patients with Dyskinetic Cerebral Palsy (STIM-CP): a Prospective Single-Arm Multicenter Trial with a Double-Blind Cross-Over at 12-Months Follow-up

Cited by 3 publications

References 0 publications

Deep brain stimulation for pediatric dystonia: a meta‐analysis with individual participant data

Deep brain stimulation for pediatric dystonia: a meta‐analysis with individual participant data

Quality of Life After Deep Brain Stimulation of Pediatric Patients with Dyskinetic Cerebral Palsy: A Prospective, Single‐Arm, Multicenter Study with a Subsequent Randomized Double‐Blind Crossover (STIM‐CP)

Long‐Term Follow‐Up of Pediatric Patients with Dyskinetic Cerebral Palsy and Deep Brain Stimulation

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