Effect of dehydrated grapefruit peels on intestinal integrity and Eimeria invasion of caprine epithelial cells in vitro and anticoccidial activity in vivo

Pérez-Fonseca, Agustín; Gutiérrez, Lilia; López, Héctor Sumano; Salem, Abdelfattah Z.M.; Ortega-Cerrilla, María Esther; Villa-Mancera, Abel; Alcalá-Canto, Yazmín

doi:10.1016/j.smallrumres.2022.106663

Small Ruminant Research

2022

DOI: 10.1016/j.smallrumres.2022.106663

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Effect of dehydrated grapefruit peels on intestinal integrity and Eimeria invasion of caprine epithelial cells in vitro and anticoccidial activity in vivo

Agustín Pérez-Fonseca¹,

Lilia Gutiérrez²,

Héctor Sumano López³

et al.

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2024

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Green Synthesis of Chitosan/Silver Nanoparticles Using Citrus paradisi Extract and Its Potential Anti-Cryptosporidiosis Effect

Alsulami,

El-Wakil

2024

Pharmaceutics

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Cryptosporidium parvum (C. parvum) is one of the most prevalent species infecting humans and animals. Currently, the only FDA-licensed drug to treat cryptosporidiosis is nitazoxanide (NTZ), with no efficacy in immunocompromised hosts. Citrus paradisi (C. paradisi) has demonstrated anti-protozoal activities. This study aimed to investigate the anti-cryptosporidiosis effect of C. paradisi peel extract, either alone or in mediating the green synthesis of chitosan silver nanoparticles (Cs/Ag NPs), compared to NTZ. Mice were sorted into nine different groups. The effectiveness of the treatments was evaluated using parasitology, histopathology, immunohistochemistry, and immunology. C. paradisi outperformed nitazoxanide regarding oocyst shedding (79% vs. 61%). The effectiveness of NTZ Cs/Ag NPs and Citrus Cs/Ag NPs was enhanced to 78% and 91%, respectively. The highest oocyst inhibition was obtained by combining NTZ and Citrus Cs/Ag NPs (96%). NF-κB, TNF-α, and Il-10 levels increased in response to infection and decreased in response to various treatments, with the highest reduction in the group treated with combined NTZ citrus Cs/Ag NPs. Combining C. paradisi with NTZ could have a synergistic effect, making it a potentially effective anti-cryptosporidiosis agent. Utilizing C. paradisi in the green synthesis of Cs/Ag NPs improves the therapeutic response and can be used to produce novel therapeutic antiparasitic drugs.

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Green Synthesis of Chitosan/Silver Nanoparticles Using Citrus paradisi Extract and Its Potential Anti-Cryptosporidiosis Effect

Alsulami,

El-Wakil

2024

Pharmaceutics

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Effect of dehydrated grapefruit peels on intestinal integrity and Eimeria invasion of caprine epithelial cells in vitro and anticoccidial activity in vivo

Cited by 1 publication

References 67 publications

Green Synthesis of Chitosan/Silver Nanoparticles Using Citrus paradisi Extract and Its Potential Anti-Cryptosporidiosis Effect

Green Synthesis of Chitosan/Silver Nanoparticles Using Citrus paradisi Extract and Its Potential Anti-Cryptosporidiosis Effect

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