Effect of Dexamethasone Administration to the Fenestra during Stapedotomy on Postoperative Dizziness

İnan, Serhat; Yılmaz, İsmail; Vural, Ömer; Yavûz, Halûk; Özer, Fulya; Hızal, Evren

doi:10.24179/kbbbbc.2021-85624

Cited by 1 publication

(5 citation statements)

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“…24 On the contrary, in our study, patients receiving topical T A B L E 1 Demographic variables of the study population. Recently, in 2021, _ Inan et al 13 conducted a study on 85 patients evaluating the early postoperative dizziness after dexamethasone injection to the fenestra. During the surgery, they administered four drops of dexamethasone phosphate (0.8 mg/0.2 mL) to fenestra.…”

Section: Discussionmentioning

confidence: 99%

“…According to the study by _ Inan et al 13 we calculated the sample size with alpha set at 0.05 and power at 0.8. The estimated sample size to detect a clinically meaningful effect was set at 35 patients in each group.…”

Section: Sample Size Calculationmentioning

confidence: 99%

“… 11 , 12 Besides, dizziness and its effect on the quality of life after stapedotomy has not been thoroughly studied in the literature. 13 …”

Section: Introductionmentioning

confidence: 99%

“…Although most studies on otosclerosis surgery have focused on hearing thresholds, postoperative dizziness can negatively impact the patient's quality of life and prolong hospital stays and medical therapy 11,12 . Besides, dizziness and its effect on the quality of life after stapedotomy has not been thoroughly studied in the literature 13 …”

Section: Introductionmentioning

confidence: 99%

“…11,12 Besides, dizziness and its effect on the quality of life after stapedotomy has not been thoroughly studied in the literature. 13 Since 1981, intratympanic dexamethasone administration has been employed as the freestanding treatment, combined with other therapies, or as a rescue treatment for inner ear disorders (e.g., tinnitus), and sudden sensorineural hearing loss. 14 Previous research found that a 4 mg/mL intratympanic dexamethasone injection had no adverse effects on outer hair cell activity, as determined by otoacoustic emissions; thus, it was considered safe.…”

Section: Introductionmentioning

confidence: 99%

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Post‐stapedotomy dizziness after applying topical steroid on footplate: A randomized controlled trial

Barati,

Shahzamani,

Tabrizi

et al. 2024

Laryngoscope Investig Oto

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BackgroundOtosclerosis is characterized by abnormal bone growth in the otie capsule. Nowadays, stapedotomy is commonly used for otosclerosis treatment. Currently, postoperative dizziness has been associated with stapedotomy. In 1981, intratympanic dexamethasone was utilized to manage inner ear disorders like tinnitus and acute sensorineural hearing loss. However, there is much uncertainty regarding the effect and safety of topical steroid therapy in the middle ear during stapedotomy. In the present study, we assessed the effect of topical steroid therapy during stapedotomy on postoperative dizziness.MethodsOtosclerosis patients eligible for stapedotomy were randomly divided into two groups based on dexamethasone administration or placebo. Audiometric and tympanometry results were observed and recorded for the involved frequencies. The Dizziness Handicap Inventory was used to quantify patient perceptions of dizziness and balance issues. Audiometry and dizziness assessments were repeated at discharge and 4 months after the operation.ResultsThe study comprised 72 otosclerosis patients undergoing stapedotomy. At discharge, the intervention group showed a significant reduction in the incidence of dizziness compared to the placebo group. However, in the 4‐month follow‐up after the operation, both groups experienced a decrease in dizziness incidence, with no significant difference between them. There was also no significant difference in audiometric levels between the two groups. Interestingly, the intervention group had a significantly lower need for systemic anti‐dizziness drugs after surgery compared to the control group.ConclusionTopical dexamethasone during stapedotomy effectively minimizes dizziness at discharge and reduces the need for postoperative anti‐dizziness medication.Level of evidence2.

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Section: Discussionmentioning

confidence: 99%

Section: Sample Size Calculationmentioning

confidence: 99%

“… 11 , 12 Besides, dizziness and its effect on the quality of life after stapedotomy has not been thoroughly studied in the literature. 13 …”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%