Effect of diclofenac on the pharmacokinetics of ciprofloxacin in quail

Abstract

This study investigated the Pharmacokinetics of ciprofloxacin alone or with diclofenac sodium in adult Japanese quails. The quails divided into two groups, the first group was dosed intraperitoneally with 50 mg/kg of ciprofloxacin, the second group was injected by 50 mg/kg of ciprofloxacin intraperitoneally then directly injected intraperitoneally by diclofenac sodium at a dosage of 5 mg/kg. Plasma concentrations of ciprofloxacin were determined by the spectrophotometer at wavelength 290 nm. Co-admiration of ciprofloxacin with diclofenac lead to appearing ciprofloxacin in plasma at 12.02, 6.4, 5.3, 3.30, 1.36, 0.60 μg/ml in the periods of 0.25, 0.50, 1, 2, 4 and 8 hours post-injection. A significantly increased in the concentration of ciprofloxacin at times of 0.25, 0.50, 1, and 2 hours post-injection and appeared at a concentration of 6.96, 3.09, 2.2, and 0.72 μg/ml. The pharmacokinetics of ciprofloxacin when given with diclofenac sodium was represented by 91% decrease in elimination constant rate, 53% decrease in elimination half-life t1/2, 64% decrease in volume of distribution to steady-state, 22% decrease in clearance, 28% increase area under curve, 41% decrease in area under moment curve, 53% decrease in mean residence time and 37% increase in maximum plasma concentration. Our study concludes that co-administration of ciprofloxacin with diclofenac sodium lead to alteration in some pharmacokinetic data of ciprofloxacin like effect on the plasma concentration and volume of distribution and clearance. This effect must be considered when therapy by ciprofloxacin with diclofenac, the co-administration of diclofenac with ciprofloxacin decrease the elimination of ciprofloxacin.

Histopathological Effects of Anabolic Androgenic Steroids (Nandrolone Decanoate) on Heart, Liver and Kidney of Male Local Rabbits

“…The increasing sensitivity linked to steroid -induce increasing in pre-ischemic myocardial CAMP concentration and increasing in both of pre-ischemic and reperfusions of the tumor necrosis factor TNF-∝ concentration. Kahal and Allem, [31], recorded in this study enlargement, sever degenerate ion and the heart muscle damage. The findings support Hassan et al [32].…”

“…In (2005), Du Toit et al [31]; recorded that the supraphysiological dose of AAS, which is taken throughout the exercise training or according to inactive condition elevated myocardial susceptibility to the ischemia or reperfusion damage. The increasing sensitivity linked to steroid -induce increasing in pre-ischemic myocardial CAMP concentration and increasing in both of pre-ischemic and reperfusions of the tumor necrosis factor TNF-∝ concentration.…”

Pregabalin potentiates the analgesic effect of tramadol, diclofenac and paracetamol in chicks: Isobolographic analysis

“…NSAIDs' analgesic and anti-inflammatory effects are primarily due to cyclo-oxygenase inhibition; however, reduced leukotriene and arachidonic acid synthesis may also play a role. NSAIDs also have a central antinociceptive effect, albeit an unknown mechanism (7). Paracetamol does not appear to have the same ability to inhibit peripheral cyclo-oxygenase (COX) activity as non-steroidal antiinflammatory medications.…”

Detection of Antibodies for Mycoplasma gallisepticum by ELISA in Broiler

“…Histopathological changes caused by M. gallisepticum infection can have a significant impact on chicken health and productivity. Early detection and management of infected birds is critical to preventing the spread of infection and minimizing its impact [25,26,27].…”