Effect of dietary selenium on the metabolism of aflatoxin B1 in turkeys

Gregory, Jesse F.; Edds, G. T.

doi:10.1016/0278-6915(84)90272-2

Cited by 23 publications

(8 citation statements)

References 27 publications

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“…The exact mechanisms of the protective role of Se on the suppression of humoral immune response of cecal tonsils caused by AFB 1 needs to elucidate by further research. However, it may be partially associated with following factors: (1) Se could improve the AFB 1 -induced impairment of bursa of Fabricius [ 19 ]; (2) Se could increase immunoglobulin synthesis and enhance B-cell function [ 54 , 55 ]; (3) Se could enhance conjugation of aflatoxins thereby increasing excretion of aflatoxins [ 56 ], and repress the formation of AFB 1 -DNA adducts [ 57 ]; (4) the protective effect of Se was mediated through a cellular mechanism related to glutathione detoxification pathways [ 52 ].…”

Section: Discussionmentioning

confidence: 99%

Sodium selenite prevents suppression of mucosal humoral response by AFB1 in broiler’s cecal tonsil

et al. 2017

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Aflatoxin B1 (AFB1), the most common mycotoxin in human food and animal feed, produces hepatotoxic, genotoxic and immunosuppressive effects in multiple species. Selenium (Se) has emerged as an important element in the dietary prevention of various toxic agents. The present study was designed to scrutinize the protective effects of sodium selenite on the histological lesions and suppression of mucosal humoral response in the cecal tonsil generated by AFB1. A total of 156 one-day-old broilers were divided into four groups and fed on basal diet (control group), 0.6 mg/kg AFB1 (AFB1 group), 0.4 mg/kg Se supplement (+Se group), and 0.6 mg/kg AFB1 + 0.4 mg/kg Se supplement (AFB1+Se group) respectively for 21 days. Our results showed that 0.4 mg/kg Se supplement in broiler's diets could improve the AFB1-induced histological lesions in the cecal tonsils including the depletion of lymphocytes in the lymphatic nodules as well as the shedding of microvilli in the absorptive cells. Moreover, Se could restore the decreased number of IgA+ cells and expression levels of pIgR, IgA, IgG, and IgM mRNA induced by AFB1 to be close to those in the control group. These results demonstrated that 0.4 mg/kg supplemented dietary Se in the form of sodium selenite could protect the cecal tonsils from the histological lesions and suppression of the mucosal humoral response provoked by 0.6 mg/kg AFB1. Our study may provide new experimental evidences for better understanding of AFB1-induced damage of mucosal immunity and protective effect of Se against this toxin.

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Section: Discussionmentioning

confidence: 99%

Sodium selenite prevents suppression of mucosal humoral response by AFB1 in broiler’s cecal tonsil

et al. 2017

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“…These phenomena may be considered as a natural security system against environmental threats to be alive during evolution. The structure of many mycotoxins has been unfold by scientists, and harmful consequences of mycotoxin residues in agricultural commodities have been well documented during the last decade that encouraged researchers to find an efficient and safe procedure to produce agricultural products prior to marketing and entering into the animal and human food chains (Aftabi, Bagherzadeh Kasmani, Jalilvand, Mehri, & Karimi Torshizi, ; Bagherzadeh‐Kasmani, Karimi‐Torshizi, Allameh, & Shariatmadari, , ; Bagherzadeh‐Kasmani & Mehri, ; Bagherzadeh‐Kasmani, Omidikia, Mirzaie, & Mehri, ; Binder, Tan, Chin, Handl, & Richard, ; Diekman & Green, ; Gregory & Edds, ; Jones, Wineland, Parsons, & Hagler, ; Li et al, ; Mohammadi, Bagherzadeh‐Kasmani, Shojaian, Mehri, & Karimi‐Torshizi, ; Murugesan et al, ; Pier, ; Zain, ; Zamani‐Zadeh & Khoursandi, ). The number of countries with specific mycotoxin regulations increased from 33 in 1981 to 100 in 2003 to protect consumers from 13 different mycotoxins through food safety policies (Van Egmond, Schothorst, & Jonker, ).…”

Section: Introductionmentioning

confidence: 99%

Excess dietary tryptophan mitigates aflatoxicosis in growing quails

khanipour

Mehri

Kasmani

et al. 2019

Animal Physiology Nutrition

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A biological assay was carried out to evaluate the impact of dietary tryptophan (TRP) in aflatoxin B1‐contaminated diets (AFB1‐D) on performance, blood parameters, immunity, meat quality and microbial populations of intestine in Japanese quails. Six experimental diets were formulated to include two levels of dietary TRP; 2.9 (moderate high: MH‐TRP) and 4.9 g/kg (excess: Ex‐TRP); and three levels of AFB1 (0.0, 2.5, and 5.0 mg/kg). Each experimental diet was fed to the one of the six groups of birds from 7 to 35 days of age in a completely randomized design with 2 × 3 factorial arrangement. Decrease in feed intake, body weight gain and gain:feed in birds fed 5.0 mg/kg AFB1‐D was restored to the control level by 4.9 g TRP/kg of the diet. The hepatic enzymes in blood were elevated in quails fed on AFB1‐D but attenuated by 4.9 g TRP/kg of the diet (Ex‐TRP; p ≤ .01). High serum uric acid in birds challenged with AFB1 significantly decreased by Ex‐TRP (p ≤ .01). The skin thickness to 2,4‐dinitro‐1‐chlorobenzene challenge suppressed by AFB1 but increased by Ex‐TRP diet (p ≤ .02). The AFB1 increased the malondialdehyde in meat, whereas TRP efficiently diminished malondialdehyde production (p ≤ .01). The greatest drip loss and pH in meat were observed in the birds fed 5.0 mg/kg AFB1‐D but Ex‐TRP augmented the adverse effects of AFB1 (p ≤ .01). The Ex‐TRP reduced the total microbial and Escherichia coli counts (p ≤ .01). The adverse effect of AFB1 on ileal Lactic acid bacteria was completely prevented by Ex‐TRP (p ≤ .03). This study showed that tryptophan supplementation could be considered as a powerful nutritional tool to ameliorate the adverse effects of AFB1 in growing quails.

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“…Some additives, such as selenium supplementation, attempt to boost detoxification, metabolic, or immune functions to counteract the effects of AFB1 [139,149,150,168,170,171,183,251]. However, most additives have been investigated for their potential to reduce AFB1 uptake by the intestine [21].…”

Section: Feed Additivesmentioning

confidence: 99%

Aflatoxicosis: Lessons from Toxicity and Responses to Aflatoxin B1 in Poultry

2015

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This review is a comprehensive introduction to the effects of poultry exposure to the toxic and carcinogenic mycotoxin aflatoxin B1 (AFB1). The relationship between AFB1 sensitivity and metabolism, major direct and indirect effects of AFB1, recent studies of gene expression and transcriptome responses to exposure, and mitigation strategies to reduce toxicity are discussed. Exposure to AFB1 primarily occurs by consumption of contaminated corn, grain or other feed components. Low levels of residual AFB1 in poultry feeds can cause reduction in growth, feed conversion, egg production, and compromised immune functions, resulting in significant economic costs to producers. Thus, AFB1 acts as a "force multiplier" synergizing the adverse effects of microbial pathogens and other agents, and factors detrimental to poultry health. Domestic turkeys (Meleagris gallopavo) are one of the most sensitive animals known to AFB1 due, in large part, to a combination of efficient hepatic bioactivation by cytochromes P450 1A5 and 3A37, and deficient hepatic glutathione-S-transferase (GST)-mediated detoxification. Because of their sensitivity, turkeys are a good model to investigate chemopreventive treatments and feed additives for their ability to reduce AFB1 toxicity. Transcriptome analysis (RNA-seq) of turkey poults (liver and spleen) has identified AFB1-induced gene expression changes in pathways of apoptosis, carcinogenesis, lipid regulation, antimicrobial activity, cytotoxicity and antigen presentation. Current research focuses on further identifying the molecular mechanisms OPEN ACCESSAgriculture 2015, 5 743 underlying AFB1 toxicity with the goal of reducing aflatoxicosis and improving poultry health.

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Effect of dietary selenium on the metabolism of aflatoxin B1 in turkeys

Cited by 23 publications

References 27 publications

Sodium selenite prevents suppression of mucosal humoral response by AFB1 in broiler’s cecal tonsil

Sodium selenite prevents suppression of mucosal humoral response by AFB1 in broiler’s cecal tonsil

Excess dietary tryptophan mitigates aflatoxicosis in growing quails

Aflatoxicosis: Lessons from Toxicity and Responses to Aflatoxin B1 in Poultry

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