Effect of different dialyzer membranes on cutaneous microcirculation during hemodialysis

Sato, Motoyoshi; Morita, Hideaki; H, Ema; Yamaguchi, Saburo; Amano, Izumi

doi:10.5414/cnp66426

Cited by 19 publications

(20 citation statements)

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“…Second, we chose the 1 h time point to avoid confounding immediate effects of HD. For example, tissue PO 2 is known to decrease immediately after the start of HD [35]. This effect may be due to relative bio-incompatibility.…”

Section: Discussionmentioning

confidence: 99%

Haemodialysis Impairs the Human Microcirculation Independent from Macrohemodynamic Parameters

Meinders

Nieuwenhuis²,

İnce³

et al. 2015

Blood Purif

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Hemodynamic changes during haemodialysis are common. Often these changes are associated with symptoms that are thought to be the result of reduced microcirculatory blood flow and oxygen delivery. The microcirculatory effect of hemodialysis is scarcely researched, though of possible influence on patient outcome. New techniques have become available to visualise and analyse microvascular blood flow. We performed an observational study using Sidestream Dark Field imaging, a microscopic technique using polarised light to visualise erythrocytes passing through sublingual capillaries, to analyse the effect of haemodyalisis on central microvascular blood flow. We showed that there is a substantial impairment of microvascular blood flow and a discrepancy between micro- and macro-vascular parameters.

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Section: Discussionmentioning

confidence: 99%

Haemodialysis Impairs the Human Microcirculation Independent from Macrohemodynamic Parameters

Meinders

Nieuwenhuis²,

İnce³

et al. 2015

Blood Purif

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“…Six studies [11,16,26,30,49,63] focused on blood vitamin C levels. Variation in plasma oxidized low density lipoprotein (Ox-LDL), nitric oxide (NOx) and thiobarbituric acid reactive substances (TBARS) were given in 11 [18,19,24,25,46,48,51,56,65,67,70] , 4 [16,22,57,62] and 8 studies [20,26,29,33,39,44,47,70] , respectively. Thirteen studies [10,20,23,26,30,33,44,48,49,51,58,64,70] reported information on total anti-oxidant status (TAS) and anti-oxidant capacity (AOC).…”

Section: Outcome Datamentioning

confidence: 99%

“…Inflammation was evaluated by changes in C-reactive protein (CRP) and interleukin-6 (IL-6) in 14 [11, 19, [18,20,59,64,70] respectively.…”

Section: Outcome Datamentioning

confidence: 99%

Effects of Vitamin E-Coated versus Conventional Membranes in Chronic Hemodialysis Patients: A Systematic Review and Meta-Analysis

et al. 2016

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Introduction: Accruing evidence suggests that vitamin E-coated membranes (ViE-m) might improve the clinical management of chronic hemodialysis (HD) patients. Methods: We conducted a systematic review and meta-analysis of RCTs comparing ViE-m to conventional HD. Endpoints of interest were a series of biomarkers pertaining to anemia status, inflammation, oxidative stress and dialysis efficacy/status. Results: Sixty studies were included. ViE-m significantly improved the Erythropoietin Resistance Index but had no impact on other anemia parameters. As for oxidative stress and inflammation, ViE-m produced a significant decrease in interleukin-6 levels, thiobarbituric acid reactive substances, plasma and red blood cell (RBC) malonylaldehyde and a significant increase in blood and RBC vitamin E. Conversely, ViE-m use had no impact on lipid profile, dialysis adequacy, blood pressure, albumin and uric acid. Conclusions: ViE-m might ameliorate anemia management by reducing oxidative stress and inflammation. Benefits of these bio-membranes on harder clinical outcomes are uncertain and need to be investigated by future, targeted trials.

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“…Our group has recently demonstrated that EVAL membrane is superior to polysulfone and vitamin E-bonded cellulose membranes for cutaneous microcirculation. 35 An approach with a new HD prescription, such as a biocompatible dialyzer, may become a candidate for further clinical trials.…”

Section: Discussionmentioning

confidence: 99%

Ethylene-Vinyl Alcohol Copolymer Dialyzer Membrane Reduces Protein Oxidation in Hemodialysis Patients

Matsumoto

Mukai

Arihara³

et al. 2011

Renal Failure

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Background: Oxidative stress has been implicated in the cardiovascular complications that affect hemodialysis (HD) patients. Ethylene-vinyl alcohol copolymer (EVAL) dialyzer membrane induces less production of reactive oxygen species as compared to conventional dialyzers. We evaluated the impact of EVAL membrane on plasma protein oxidation in HD patients. Methods: HD patients treated with cellulose triacetate (CTA) dialyzers were selected. In the first study performed in a 2-month crossover design alternating between CTA and EVAL, nonmercaptalbumin and advanced oxidation protein products levels were measured in the predialysis blood from 10 subjects. In the second study, predialysis plasma myeloperoxidase levels were measured before and after a 2-week EVAL treatment on 12 patients. Results: Plasma advanced oxidation protein products levels were reduced after a 2-month EVAL treatment and increased again after CTA treatment, although the nonmercaptalbumin proportions were not affected significantly by the change in dialyzer membranes. The following study, a 2-week EVAL treatment, showed the decrease in myeloperoxidase levels immediately before HD. Conclusion: The frequent use of EVAL dialyzers has been shown to reduce protein oxidation, possibly through the suppression of circulating phagocytes. This novel biocompatible dialyzer is expected to protect cardiovascular mortality in HD patients.

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Effect of different dialyzer membranes on cutaneous microcirculation during hemodialysis

Cited by 19 publications

References 0 publications

Haemodialysis Impairs the Human Microcirculation Independent from Macrohemodynamic Parameters

Haemodialysis Impairs the Human Microcirculation Independent from Macrohemodynamic Parameters

Effects of Vitamin E-Coated versus Conventional Membranes in Chronic Hemodialysis Patients: A Systematic Review and Meta-Analysis

Ethylene-Vinyl Alcohol Copolymer Dialyzer Membrane Reduces Protein Oxidation in Hemodialysis Patients

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