Effect of different lubricant eye gels on tear film thickness as measured with ultrahigh‐resolution optical coherence tomography

Woźniak, Piotr A.; Schmidl, Doreen; Bata, Ahmed M.; Fondi, Klemens; Witkowska, K.; Santos, Valentin Aranha dos; Baar, Carina; Room, Kim I.; Nepp, Johannes; Baumgartner, Isabella; Popa-Cherecheanu, Alina; Garhöfer, Gerhard; Werkmeister, René M.; Schmetterer, Leopold

doi:10.1111/aos.13342

Cited by 31 publications

(31 citation statements)

References 67 publications

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“…Although the observed change in TFT is small, the strength of the OCTbased measurement of TFT is that with a coefficient of variation of less than 4% the instrument is capable of detecting subtle changes in TFT in patients with DED [12]. As such, we have reported in previous experiments using the same UHR-OCT system that treatment with topical lubricants leads to a short-time increase in TFT depending on the physical properties of the agent applied [16][17][18][19]. The data of the current experiment extend these previous findings, showing that a short-time topical anti-inflammatory therapy can increase precorneal TFT.…”

Section: Discussionmentioning

confidence: 92%

Topical Low Dose Preservative-Free Hydrocortisone Reduces Signs and Symptoms in Patients with Chronic Dry Eye: A Randomized Clinical Trial

et al. 2019

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Purpose: Dry eye disease (DED) is a highly prevalent ocular condition with a significant burden on affected patients. Regardless of the underlying etiology, DED is associated with increased ocular surface inflammation. We investigated the safety and efficacy of a shortterm treatment with topical low dose hydrocortisone in patients with chronic DED and ocular surface inflammation. Methods: A total of 60 patients (mean age 51 ± 14 years) with chronic DED and conjunctival hyperemia greater than grade 2 on the Efron scale were included. Patients were randomized to receive either preservative-free hydrocortisone 0.335% (Softacort, Laboratories Thea, France) for 12 days four times daily followed by 2 days twice daily instillation (intense treatment group) or 8 days three times daily followed by 3 days twice daily treatment (standard treatment group). Ocular redness was assessed at baseline, day 14, and day 28. Measurement of intraocular pressure (IOP) and clinical tests to assess signs and symptoms of DED were performed. Results: Conjunctival hyperemia and Ocular Surface Disease Index (OSDI) significantly decreased in both treatment groups (p \ 0.001 each) after hydrocortisone treatment. A significant increase in tear film thickness was seen 4 weeks after treatment start (p = 0.03 and p = 0.04, respectively). IOP did not change in either of the two treatment groups (p = 0.45). Conclusion: Treatment with low dose hydrocortisone 0.335% reduced ocular inflammation and decreased OSDI score. No change in IOP was observed in either of the two treatment schedules. Because of its good safety profile, low dose The original version of this article was revised due to retrospective open access.

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Section: Discussionmentioning

confidence: 92%

Topical Low Dose Preservative-Free Hydrocortisone Reduces Signs and Symptoms in Patients with Chronic Dry Eye: A Randomized Clinical Trial

et al. 2019

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“…; Wozniak et al. ). However, no studies exist relating this to the tear turbidity and patient's symptoms.…”

Section: Introductionmentioning

confidence: 97%

Evaluation of tear meniscus by optical coherence tomography after different sodium hyaluronate eyedrops instillation

Carracedo

Pastrana

Serramito

et al. 2018

Acta Ophthalmologica

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Purpose: To evaluate changes in tear meniscus dynamics using optical coherence tomography (OCT) after the instillation of different concentrations of sodium hyaluronate (SH) ophthalmic solutions. Methods: An experimental, double-masked, randomized study was performed. Twenty-three healthy subjects (16 women and seven men; mean age 23.57 AE 2.56 years) participated in this study. About 35 ll of 0.1%, 0.2%, 0.3% SH ophthalmic solutions and saline solution was instilled in a randomly assigned eye. Tear meniscus measurements (height, depth and turbidity) were taken with OCT at 30 seconds and 1, 3, 5, 10 and 20 min after instillation. Subsequently, the Schirmer test and tear break-up time (TBUT) were evaluated. Results: Tear meniscus depth and tear meniscus height showed a significant increase with all solutions compared to basal values: up to 3 min for 0.1% SH, up to 5 min for 0.2% and up to 10 min for 0.3% SH ophthalmic solution. Tear meniscus turbidity was also increased at 30 seconds for 0.1%, 0.2% and 0.3% SH artificial tears (p < 0.05). This increase remained significant for up to 1 min for 0.2% and 0.3% SH solutions (p < 0.05). After 5 min of saline and 0.1% SH instillation, the turbidity was lower than basal values (p < 0.05). There was a significant increase in the TBUT for all solutions after instillation (p < 0.05). No differences between the Schirmer pre-and postinstillation were found (p > 0.05). Finally, the comfort was significantly improved for all ophthalmic solutions (p < 0.05). Conclusion: Sodium hyaluronate (SH) ophthalmic solutions increase residence time in healthy subjects and are positively correlated with its concentration and therefore the viscosity.

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“…In a recent prospective study, the capacity to longitudinally quantify changes to tear film thickness was demonstrated in a study of 30 individuals with glaucoma who were changed from preserved topical prostaglandin therapy to a non‐preserved formulation . Similarly, the ability to quantify progressive changes in tear film thickness, as a measure of the degree of ocular retention, was reported in a cohort of patients with mild‐to‐moderate dry eye disease, following administration of a single drop of different topical lubricant products …”

Section: An Overview Of As‐oct Imaging In Humansmentioning

confidence: 99%

Anterior segment optical coherence tomography: its application in clinical practice and experimental models of disease

Jiao

Hill

Downie

et al. 2019

Clinical and Experimental Optometry

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Optical coherence tomography (OCT) provides non-invasive, high-resolution in vivo imaging of the ocular surface and anterior segment. Over the years, it has become an essential tool for evaluating the anterior segment of the eye to monitor ocular development and ocular pathologies in both the clinical and research fields of ophthalmology and optometry. In this review, the clinical applications relating to the use of anterior segment OCT for imaging and quantifying normal and pathological features of the ocular surface, cornea, anterior chamber, and aqueous outflow system are summarised in a range of human ocular diseases. Applications of anterior segment OCT technology that have improved imaging and quantitation of ocular inflammation in experimental animal models of ocular diseases, such as anterior uveitis, microbial keratitis and glaucoma, are also described. The capacity to longitudinally evaluate anterior segment anatomical changes during development, and inflammation facilitates the understanding of the dynamics of tissue responses, and further enhances the intra-operative in vivo imaging during procedures, such as corneal transplantation and drug delivery. Future developments including in vivo ultrahigh-resolution anterior segment OCT, automated analyses of anterior segment OCT images and functional extensions of the technique, may revolutionise the clinical evaluation of anterior segment, corneal and ocular surface diseases.

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Effect of different lubricant eye gels on tear film thickness as measured with ultrahigh‐resolution optical coherence tomography

Cited by 31 publications

References 67 publications

Topical Low Dose Preservative-Free Hydrocortisone Reduces Signs and Symptoms in Patients with Chronic Dry Eye: A Randomized Clinical Trial

Topical Low Dose Preservative-Free Hydrocortisone Reduces Signs and Symptoms in Patients with Chronic Dry Eye: A Randomized Clinical Trial

Evaluation of tear meniscus by optical coherence tomography after different sodium hyaluronate eyedrops instillation

Anterior segment optical coherence tomography: its application in clinical practice and experimental models of disease

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