Effect of Different Molecular Weights of Chitosan on Formulation and Evaluation of Allopurinol-Loaded Nanoparticles for Kidney Targeting and in Management of Hyperuricemic Nephrolithiasis

Kandav, Gurpreet; Bhatt, Dinesh Chandra; Singh, Shailendra Kumar

doi:10.1208/s12249-022-02297-7

Cited by 8 publications

(4 citation statements)

References 25 publications

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“…Также существуют данные, указывающие на различную тропность наночастиц, полученных из хитозана с различной молекулярной массой, к тканям почки у лабораторных животных. При этом наибольшую тропность демонстрировали образцы с наименьшей молекулярной массой [41]. Следует обратить внимание на то, что авторы данной работы предпочли не определять молекулярную массу хитозана в единицах массы, а указали только показатели вязкости, которые имеют, как было продемонстрировано ранее, лишь частичную связь с реальным размером молекулы хитозана.…”

Section: различия по определению молекулярной массыunclassified

On Individual Aspects of Chotisan Samples Characterisation in Biomedical Research

Khalimov¹,

Omelko²,

Rusin³

2022

НО БН (SR BS)

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Настоящий обзор рассматривает влияние, которое технологии получения хитозана и его подготовки к применению в биомедицинских исследованиях оказывают на его физико-химические и биологические свойства. Описаны основные подходы к получению хитозана из природного сырья, а также основные и эмержентные источники хитина. Подчёркнуты неодинаковые свойства хитина, содержащегося в различных источниках, и описаны теоретические основы, связывающие данные свойства со свойствами получаемого хитозана. Также в данной работе рассмотрены экспериментально подтверждённые различия в физико-химических свойствах хитозана, выделенного из различных источников. Помимо этого представлена совокупность имеющихся данных, характеризующих токсичность и биосовместимость хитозана в качестве материала для применения в регенеративной медицине и тканевой инженерии. Отдельно описана существенная проблема характеризации образцов хитозана с различным происхождением и различной молекулярной массой, которая может быть причиной низкой воспроизводимости результатов исследований хитозана. Невозможность точного определения молекулярной массы хитозана без экспериментального её измерения взаимно связана с зачастую недостаточной ясностью источника его происхождения. Подобная запутанность может стать непреодолимым препятствием на пути создания стандартизованных продуктов и медицинских изделий на основе хитозана.

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Section: различия по определению молекулярной массыunclassified

On Individual Aspects of Chotisan Samples Characterisation in Biomedical Research

Khalimov¹,

Omelko²,

Rusin³

2022

НО БН (SR BS)

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“…Chitosan (CS) has good biocompatibility and is a promising polymer in the biomedical field. Studies have shown that CS has mucosal adhesion properties, can increase the permeability of drugs in the intestinal epithelium, and is a potential oral absorption enhancer. , Meanwhile, CS shows selective accumulation in the kidney due to the specific binding of amino groups and glucosamine units to the megalin protein receptors of renal tubular epithelial cells. − The glomerular filtration barrier limits the entry of large nanoparticles (NPs) into the glomeruli. In contrast, CS NPs with low molecular weight can effectively control the particle size in the range of 10–100 nm so that the NPs have better renal targeting. , Deoxycholic acid (DA) has a specific affinity for apical sodium-dependent bile acid transporter (ASBT) at the top of intestinal epithelium and enters cells through receptor endocytosis pathway and then escapes through lysosomes to achieve efficient intracellular transport.…”

Section: Introductionmentioning

confidence: 99%

Intestinal Absorption of Nanoparticles to Reduce Oxidative Stress and Vasoconstriction for Treating Diabetic Nephropathy

Liu,

Pang,

Wang

et al. 2024

ACS Biomater. Sci. Eng.

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The etiology of diabetic nephropathy (DN) is complex, and the incidence is increasing year by year. The patient's kidney showed oxidative stress damage, increasing active oxygen species (ROS) content, and vasoconstriction. Due to poor drug solubility and low renal accumulation, the current treatment regimens have not effectively alleviated glomerulopathy and other kidney damage caused by DN. Therefore, it is of great significance to explore new treatment strategies and drug delivery systems. Here, we constructed an oral nanodelivery system (Tel/CAN@CS-DA) that reduced oxidative stress and vasoconstriction. Deoxycholic acid (DA)-modified nanoparticles entered into intestinal epithelial cells (Caco2 cells) via the bile acid biomimetic pathway, then escaped from the lysosomes and eventually spat out the cells, increasing the oral absorption of nanoparticles. Chitosan (CS) nanoparticles could achieve renal targeting through specific binding with a renal giant protein receptor and deliver drugs to renal tubule epithelial cells (HK-2 cells). In vitro studies also proved that telmisartan (Tel) and canagliflozin (CAN) effectively removed cellular reactive oxygen species (ROS) and reduced HK-2 cell apoptosis caused by high glucose. In the in vivo model induced by streptozotocin (STZ), the results showed that the nanosystem not only elevated AMPK protein expression, inhibited angiotensin II (Ang II) protein expression to effectively reduce oxidative stress level, dilated renal blood vessels but also reduced the degree of inflammation and fibrosis. Overall, Tel/CAN@CS-DA multifunctional oral nanosystem can effectively treat DN with low toxicity, which provides a new idea for the treatment of DN.

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“…Various drug delivery methods have been investigated during the past decades, which mainly included two strategies: to prolong the contact time and increase corneal permeability of drug. [3][4][5] Nanotechnology based ocular drug delivery systems are a promising platform owing to their small size and customizable surface properties that facilitate corneal penetration via ocular tissues and provide higher ocular bioavailability. Therefore, problems related to the conventional eye drops of TM and unintended side effects are overcome by nanoparticles.…”

Section: Introductionmentioning

confidence: 99%

Design and Characterization of Timolol Loaded Gellan Gum Nanoparticles for Improved Ocular Drug Delivery

Kandav,

Lochab,

Sharma

2024

Ind. J. Pharm. Edu. Res

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Effect of Different Molecular Weights of Chitosan on Formulation and Evaluation of Allopurinol-Loaded Nanoparticles for Kidney Targeting and in Management of Hyperuricemic Nephrolithiasis

Cited by 8 publications

References 25 publications

On Individual Aspects of Chotisan Samples Characterisation in Biomedical Research

On Individual Aspects of Chotisan Samples Characterisation in Biomedical Research

Intestinal Absorption of Nanoparticles to Reduce Oxidative Stress and Vasoconstriction for Treating Diabetic Nephropathy

Design and Characterization of Timolol Loaded Gellan Gum Nanoparticles for Improved Ocular Drug Delivery

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