Effect of dimethylsulfate on the structure and cytoarchitectonics of rat thymus

Abstract

Changes of structure and cell ratios of different functional zones in the thymus under conditions of long-term dimethylsulfate administration at 0.1 and 2.0 mg/m 3 on the organism are studied morphometrically on histological preparations from Wistar rats. Cyclic reactions of the thymus to the toxic substance are found to be due to compensatory processes. It is shown that the nature of the reaction does not depend on the concentration of toxic substance but that the extent of changes is a function of the dimethylsulfate concentration.

Reaction of different functional zones in mouse thymus and spleen lymphoid tissue to γ-irradiation

“…The dynamics of postirradiation reparative processes is little studied. We have previously demonstrated a cyclic pattern of reparative processes in the immune system after exposure to some factors (toxicants) [4,7,8]. In the present study we investigated changes in cell populations of different thymie and splenic functional zones in mice exposed to ,t-radiation in a single dose of 6.9 Gy.…”