Effect of Dithiocarbamates on Sarcoma Cells and Fibrocytes Cultured In Vitro

Ak, Powell

doi:10.1038/bjc.1954.56

Cited by 13 publications

(8 citation statements)

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“…Some 35 years ago DDTC's in vitro cytotoxicity was attributed to its high affinity chelation of metal cations effecting a covalent inactivation of key metalloenzymes [2]. Certainly, such a mechanism would be consistent with the rapid and apparently irreversible effect of DDTC on JM and MOLT3 cells when using just 2 minute exposures.…”

Section: Discussionmentioning

confidence: 94%

“…Cd, Ni [1]), in the vulcanization of rubber, in aversion therapy for alcohol addiction as well as in other applications [1][2][3]. In the oncology setting there has been clinical interest in the complex and possibly useful "immune restorative" effects of diethyldithiocarbamate ("DDTC") and its oxidized form, disulfiram [4,5].…”

Section: Introductionmentioning

confidence: 99%

“…Unfortunately, DDTC never displayed potentially useful tumoricidal efficacy in its own right despite predictions based upon its potent inhibition of key cellular enzymes [2,4]. Instead, it was consistently shown in various murine, rat, and hamster cell lines that cell survival decreased profoundly after exposure to 0.1 to 1.0/xg DDTC/ml but cell survival was greater or even normal using higher concentrations of 10 to 100 #g/ml [e.g.…”

Section: Introductionmentioning

confidence: 99%

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Cytotoxicity of diethyldithiocarbamate in human versus rodent cell lines

Cohen¹,

Robins²

1990

Invest New Drugs

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Diethyldithiocarbamate (DDTC) and other dithiocarbamates are currently receiving attention as potential adjuncts to traditional chemotherapy. In vitro studies with rodent cancer cell lines have consistently shown that DDTC concentrations of 0.1-1.0 micrograms/ml are highly cytotoxic. Paradoxically, however, concentrations of 10-100 micrograms/ml have been significantly less toxic. In the present study, such a 'biphasic' pattern was reproduced when 3 rodent cell lines were exposed for 1 hour to 0.001 to 1000 micrograms DDTC/ml. In contrast, in 7 human cell lines survival decreased steadily with increasing DDTC concentration (in the same dose range) without evidence of a biphasic pattern. These data might have implications for studies in which rodent cell lines are used to model the effects of dithiocarbamates in human tissues.

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Section: Discussionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Cytotoxicity of diethyldithiocarbamate in human versus rodent cell lines

Cohen¹,

Robins²

1990

Invest New Drugs

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“…Their versatility and applicability was discussed by Kitson. 1 The interest in the solution stability of dithiocarbamates has been renewed by the utilization of such compounds as coadjutants in the treatment of AIDS, 2,3 but they have also been suggested for tuberculosis 4 and cancer 5 treatment in the past. These applications demand enough chemical stability for an effective action in the biological medium.…”

Section: Introductionmentioning

confidence: 99%

Thermoanalytical and solution stability studies of hexamethylenedithiocarbamates

Benedini¹,

Antunes²,

Cavalheiro³

et al. 2006

J. Braz. Chem. Soc.

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Estudos termogravimétricos e calorimétricos exploratórios diferenciais de hexametilenoditiocarbamatos de níquel(II), cobre(II), zinco(II) e cádmio(II) foram realizados sob atmosferas dinâmicas de ar e nitrogênio, para avaliar as etapas e os produtos de decomposição térmica. Esses produtos, quando cristalinos, foram caracterizados por difratometria de raios X, sendo predominantemente constituídos por sulfetos e óxidos metálicos sob N 2 e ar, respectivamente. Usando espectrofotometria na região do ultravioleta, também foram determinados o pK a = 3,6 ± 0,2 para o ácido hexametilenoditiocarbâmico em força iônica igual a 0,50 mol dm -3 (KCl) a 25,0 °C e os parâmetros cinéticos de decomposição em diferentes valores de pH (k lim = 2,21 × 10 -2 s -1 e t ½ lim = 156 s).Thermogravimetric and differential scanning calorimetric investigation of the thermal behavior of nickel(II), copper(II), zinc(II) and cadmium(II) hexamethylenedithiocarbamates were performed under nitrogen and air atmospheres in order to investigate the steps and products of thermal decomposition. When obtained in a crystalline form, the decomposition products were identified by their X-ray diffraction patterns. Metal sulfides and oxides were the major residues under nitrogen and air atmospheres, respectively. Spectrophotometric measurements in the ultraviolet region were used to estimate the pK a = 3.6 ± 0.2 for the haxamethylenedithiocarbamic acid at 0.50 mol dm -3 ionic strength (KCl) at 25.0 °C and the kinetic parameters of decomposition at different pH values (k lim = 2.21 × 10 -2 s -1 and t ½ lim = 156 s).

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“…Atualmente, o interesse neste compostos foi renovado pela proposta de sua utilização como auxiliar no tratamento de AIDS 9,10 . Entretanto, já foram também utilizados como coadjuvantes no tratamento de câncer 11 , tuberculose 12 e na remoção de metais pesados de organismos vivos 7 .…”

Section: I11 Aplicaçõesunclassified

"Preparação e aplicação de eletrodos de pasta de carbono modificados com ditiocarbamatos para análise de fármacos"

Silva¹

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Effect of Dithiocarbamates on Sarcoma Cells and Fibrocytes Cultured In Vitro

Cited by 13 publications

References 1 publication

Cytotoxicity of diethyldithiocarbamate in human versus rodent cell lines

Cytotoxicity of diethyldithiocarbamate in human versus rodent cell lines

Thermoanalytical and solution stability studies of hexamethylenedithiocarbamates

"Preparação e aplicação de eletrodos de pasta de carbono modificados com ditiocarbamatos para análise de fármacos"

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