Effect of Dobutamine Stress on Ocular Blood Flow Measurements Using 3D Pseudocontinuous Arterial Spin Labeling

Abstract

Dobutamine stress testing is a very widely used tool in cardiological investigation. However, little is known about the effect of dobutamine on adult ocular blood flow with clinical dosage. In this study, we infused dobutamine in human subjects and examined the effects of dobutamine on ocular blood flow using 3D pseudocontinuous arterial spin labeling(3D-pcASL). Dobutamine infusion significantly increased the ocular blood flow. And the heart rate and diastolic blood pressure were the main factors affecting the ocular blood flow.