Effect of donor preservation solution and survival in lung transplantation

Marasco, Silvana; Bailey, Michael; McGlade, Daniel; Snell, Gregory I; Westall, Glen P.; Oto, Takahiro; Pilcher, David

doi:10.1016/j.healun.2010.10.002

Cited by 25 publications

(11 citation statements)

References 10 publications

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“…This inherent quality may limit ischemia in regions of microcirculation thrombosis while creating an osmotic gradient that reduces protein and water extravasation during the reperfusion period . In a clinical study, the absence of dextrose in extracellular solutions has been associated with an increased incidence of primary graft dysfunction and mortality (Marasco, et al, 2011;Oto, et al, 2006). While long-term outcomes remain the focus of future investigation, these findings support the clinical adoption of low-potassium dextran solutions as the primary method for lung allograft preservation.…”

Section: Lung Preservation Strategiesmentioning

confidence: 81%

Pulmonary Transplantation and Ischemia-Reperfusion Injury

Sharma¹,

Stone²,

Lau³

et al. 2012

Topics in Thoracic Surgery

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Section: Lung Preservation Strategiesmentioning

confidence: 81%

Pulmonary Transplantation and Ischemia-Reperfusion Injury

Sharma¹,

Stone²,

Lau³

et al. 2012

Topics in Thoracic Surgery

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“…A number of clinical studies have demonstrated the benefit of using LPD solutions for lung preservation,62 including improved recipient oxygenation, improved reperfusion scores, and shorter duration on mechanical ventilation. Furthermore, LPD utilization was associated with a reduced incidence of primary graft dysfunction at 48 hours after lung transplantation compared with other preservation solutions 63…”

Section: Technologymentioning

confidence: 95%

Innovations in Organ Donation

Goldstein¹,

Lubezky²,

Yushkov³

et al. 2012

Mount Sinai J Medicine

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The growing disparity between organ availability for transplantation and the number of patients in need has challenged the donation and transplantation community of practice to develop innovative processes, ideas, and techniques to bridge the gaps. Advances in the sharing of best practices in the donation community have contributed greatly over the last 8 years. Broader sharing of updated guidelines for declaration of brain death in conjunction with improvements in deceased donor management have increased opportunities for organ donation. New techniques for organ preservation and organ resuscitation have allowed for better utilization of the potential donor pool. This review will highlight processes, ideas, and techniques in organ donation.

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“…Nicht nur die Beurteilung der Organqualität, auch die Protektion des Organs ist wesentlich für den postoperativen Verlauf. Die Low-Potassium-Dextran-Perfusionslösung (LPD-Lösung) vermindert das Risiko des primären Graftversagens und ist in Bezug auf die Organprotektion anderen Lösungen überlegen [40][41][42].…”

Section: Protektion Und Perfusionslösungunclassified

Aktuelle Aspekte der Lungentransplantation

Samson-Himmelstjerna¹

2018

Zentralbl Chir

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Since 1963, the lung transplantation has become a successful and established therapy for patients with lung failure. Even though mortality is higher than with other solid organ transplantations, remarkable progress has been made due to improved techniques, improved conservation, immunosuppression and antibiotics as well as diagnostic tools and therapy for rejection. The survival for lung transplantation is good. The survival rate after 3 months is 88%, after 1 year 79% and after 3, 5, and 10 years 64%, 53%, and 31%, respectively. But chronic rejection, presenting as chronic lung allograft dysfunction, is still a major problem after lung transplantation. An overview of indications and contraindications, surgical techniques and results is given in this article.

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Effect of donor preservation solution and survival in lung transplantation

Cited by 25 publications

References 10 publications

Pulmonary Transplantation and Ischemia-Reperfusion Injury

Pulmonary Transplantation and Ischemia-Reperfusion Injury

Innovations in Organ Donation

Aktuelle Aspekte der Lungentransplantation

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