Effect of early and delay starting of enteral feeding in post-pancreaticoduodenectomy patients

Das, Bidhan Chandra; Haque, Md. Ashraful; Uddin, Mohammad Saief; Nur-E-Elahi, M; Khan, Zulfiqur Rahman

doi:10.14701/ahbps.2019.23.1.56

Cited by 3 publications

(1 citation statement)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, no meta-analysis has studied the effect of early EN on nutritional status. Das et al [ 9 ] showed that early EN support cannot significantly improve the nutritional status of patients compared with traditional nutritional support. This study aimed to quantitatively investigate the effect of early nutritional support on nutritional status of patients undergoing gastrointestinal surgery based on meta-analysis.…”

Section: Introductionmentioning

confidence: 99%

Nutritional status efficacy of early nutritional support in gastrointestinal care: A systematic review and meta-analysis

He¹,

Liu²,

He³

et al. 2023

World J Gastrointest Surg

View full text Add to dashboard Cite

BACKGROUND Gastrointestinal surgery is a complicated process used to treat many gastrointestinal diseases, and it is associated with a large trauma: Most patients often have different degrees of malnutrition and immune dysfunction before surgery and are prone to various infectious complications during postoperative recovery, thus affecting the efficacy of surgical treatment. Therefore, early postoperative nutritional support can provide essential nutritional supply, restore the intestinal barrier and reduce complication occurrence. However, different studies have shown different conclusions. AIM To assess whether early postoperative nutritional support can improve the nutritional status of patients based on literature search and meta-analysis. METHODS Articles comparing the effect of early nutritional support and delayed nutritional support were retrieved from PubMed, EMBASE, Springer Link, Ovid, China National Knowledge Infrastructure, China Biology Medicine databases. Notably, only randomized controlled trial articles were retrieved from the databases (from establishment date to October 2022). The risk of bias of the included articles was determined using Cochrane Risk of Bias V2.0. The outcome indicators, such as albumin, prealbumin, and total protein, after statistical intervention were combined. RESULTS Fourteen literatures with 2145 adult patients undergoing gastrointestinal surgery (1138 patients (53.1%) receiving early postoperative nutritional support and 1007 patients (46.9%) receiving traditional nutritional support or delayed nutritional support) were included in this study. Seven of the 14 studies assessed early enteral nutrition while the other seven studies assessed early oral feeding. Furthermore, six literatures had "some risk of bias," and eight literatures had "low risk". The overall quality of the included studies was good. Meta-analysis showed that patients receiving early nutritional support had slightly higher serum albumin levels, than patients receiving delayed nutritional support [MD (mean difference) = 3.51, 95%CI: -0.05 to 7.07, Z = 1.93, P = 0.05]. Also, patients receiving early nutritional support had shorter hospital stay (MD = -2.29, 95%CI: -2.89 to -1.69), Z = -7.46, P < 0.0001) shorter first defecation time (MD = -1.00, 95%CI: -1.37 to -0.64), Z = -5.42, P < 0.0001), and fewer complications (Odd ratio = 0.61, 95%CI: 0.50 to 0.76, Z = -4.52, P < 0.0001) than patients receiving delayed nutritional support. CONCLUSION Early enteral nutritional support can slightly shorten the defecation time and overall hospital stay, reduce complication incidence, and accelerate the rehabilitation process of patients undergoing gastrointestinal surgery. ...

show abstract

Section: Introductionmentioning

confidence: 99%

Nutritional status efficacy of early nutritional support in gastrointestinal care: A systematic review and meta-analysis

He¹,

Liu²,

He³

et al. 2023

World J Gastrointest Surg

View full text Add to dashboard Cite

show abstract

The impact of early peroral feeding on concentration of the serum interleukin–6 in patients after pancreaticoduodenectomy

Skums¹,

Kuzmenko²,

Stasenko³

2020

View full text Add to dashboard Cite

Objective. The impact of early peroral feeding on concentration of the serum interleukin-6 in patients after pancreaticoduodenectomy was analyzed. Materials and methods. Results of pancreaticoduodenectomy in 39 patients, suffering the pancreatic head and periampullar zone tumors, was analyzed, in whom various methods of nutritive support were applied through period 2015 - 2017 yrs. With the aim of comparative analysis accomplishment of immunological reactivity the patients were divided into two groups: the first - 24 patients, to whom in postoperative period a combination of peroral and enteral feeding was conducted, and in the second - 15 patients, to whom peroral feeding was applied only. There were studied concentration of the serum interleukin-8 preoperatively and on the third postoperative day, as well as the levels of general protein and albumin on the first, third and 7th postoperative days. Results. In the patients, to whom nutritive support was done in a combined way (through microjejunostomy and in a peroral way), the level of interleukin-6 was higher (p=0.05), than in the patients, who used a peroral feeding only postoperatively: mediana 76.2 [51.5; 96.4] and 63.4 [43.5; 65,7] pg/ml, accordingly (p=0.055). While application of various methods of feeding in the patients a trustworthy difference between middle levels of albumin and general protein in the blood on the first, third and 7th days after pancreaticoduodenectomy was not observed (p > 0.05) while application of different feeding methods. Conclusion. Application of combined enteral and peroral feeding in patients after pancreaticoduodenectomy has no advantages upon a peroral one. Early peroral feeding promotes the reduction of immunological reactivity of organism as an answer on operative trauma, and the proteins levels, comparing with combined feeding in patients in postoperative period up to the 7th day do not differ essentially.

show abstract

Efficacy of early enteral nutrition to enhance recovery after major abdominal surgeries in cancer patients

Elbardan,

Argawy Hussein,

ElRazek Abd-Rabih

2023

Research and Opinion in Anesthesia &Amp; Intensive Care

View full text Add to dashboard Cite

Background Malnutrition is a significant prognostic factor in surgical cancer patients, especially when the malignancy is localized to the gastrointestinal tract. Aim The goal of this study was to evaluate the impact of early enteral feeding on nutritional status and clinical outcomes in patients who had undergone abdominal surgery for cancer. Patients and methods Forty patients, ranging in age from 20 to 60 years, admitted to the postoperative surgical ICU underwent preoperative nutritional assessment and were followed daily from the morning of postoperative day 1 in the ICU until the evening of day 4 for the possibility of starting enteral nutrition safely. Participants were differentiated into early and late groups according to the time of establishment of enteral feeding. To compare early and late groups of the studied patients, clinical and laboratory nutritional markers and clinical outcomes were traced and statistically analyzed. Results Both groups had 12 (60%) males and eight (40%) females, with a mean±SD age of 43.6±8.15 years in the early group and 41.75±6.65 years in the late group. The early group had a substantially higher mean percentage BMI gain (2.50±0.35) than the late group (0.89±0.20). The early group had statistically higher serum prealbumin levels than the late group after 4 days. Early enteral feeding increased the prealbumin percentage by 25.37±5.93 compared with 15.93±1.98 in the late group. Early enteral feeding increased the total cholesterol levels. Early enteral feeding had a mean cholesterol percentage change of 32.04±6.74% compared with 17.23±4.23% in the late group. Early enteral nutrition patients spent 3.2±0.77 days in the ICU compared with 5.2±0.77 days for the late group. Patients in the early group had a considerably shorter hospital stay (6.8±1.51 days) than those in the late group (10.2±1.51 days). The incidence of superficial surgical infection was 40% in the late group compared with none in the early group, and the two groups differed statistically significantly. Conclusion The nutritional status of patients with cancer who undergo major abdominal surgery greatly benefits from beginning enteral feeding early. The incidence of surgical complications decreased, and hospital and ICU stays were shortened when enteral feeding was started early.

show abstract

Effect of early and delay starting of enteral feeding in post-pancreaticoduodenectomy patients

Cited by 3 publications

References 18 publications

Nutritional status efficacy of early nutritional support in gastrointestinal care: A systematic review and meta-analysis

Nutritional status efficacy of early nutritional support in gastrointestinal care: A systematic review and meta-analysis

The impact of early peroral feeding on concentration of the serum interleukin–6 in patients after pancreaticoduodenectomy

Efficacy of early enteral nutrition to enhance recovery after major abdominal surgeries in cancer patients

Contact Info

Product

Resources

About