Effect of early oral clindamycin on late miscarriage and preterm delivery in asymptomatic women with abnormal vaginal flora and bacterial vaginosis: a randomised controlled trial

Antibiotics for treating bacterial vaginosis in pregnancy

“…In addition, in the latter trial only 11 women in each group had bacterial vaginosis. Another trial (Lamont 2003;Ugwumadu 2003). These have been included because of evidence that women with intermediate vaginal flora are also at higher risk of preterm birth (Hay 1994a).…”

Whole-Exome Sequencing and Whole-Genome Sequencing in Critically Ill Neonates Suspected to Have Single-Gene Disorders

“…In addition to germline mutations, somatic or post-zygotic mutations also occur, causing genetic diseases. In the context of neo-natal medicine, this would be most important for disorders related to mosaicism such as in McCune -Albright syndrome, incontinentia pigmenti, and Sturge -Weber syndrome (van den Akker et al 2009;Erickson 2010;Shirley et al 2013). Mosaicism is probably more common than previously thought, with parental germline mosaicism in singleton children with genetic diseases estimated to be at least 4% (Huisman et al 2013;Campbell et al 2014).…”

“…About 30% of conceptions are lost before implantation and 30% between implantation and the fourth week of gestation ( preclinical loss) (Macklon et al 2002). Approximately 15% of conceptions are lost between the fourth and 12th week of gestation (early clinical pregnancy loss), and 4% between 12 and 22 wk gestation (late loss) (Ellish et al 1996;Zinaman et al 1996;Nybo et al 2000;Ugwumadu et al 2003). Older data suggested that, of all clinically recognized pregnancies, 15% -20% end in miscarriage (Warburton and Fraser 1964) and of those analyzed, a high rate of anatomic and chromosomal abnormalities were identified (Garcia et al 2006).…”

Current views on vaginal microbiota and its impact on pregnancy outcomes

“…Однако систематический обзор зарубежных рандоми-зированных клинических исследований пока-зал, что пероральное применение клиндамици-на беременными женщинами с БВ до 22 недель гестации существенно снизило риск поздних выкидышей и преждевременных родов [45]. Также А. Ugwumadu et al установили, что вы-явление и лечение БВ пероральным клиндами-цином на сроках беременности 12-22 недели привело к значительному снижению поздних выкидышей и спонтанных преждевременных родов (12 % -в группе плацебо и 5 % -в груп-пе лечения и 4 % -в группе плацебо и 1 % -в группе лечения соответственно) [58].…”