Effect of Eclipta prostrata on lipid metabolism in hyperlipidemic animals

Zhao, Yun; Lu, Peng; Lü, Wei; Wang, Yiqing; Huang, Xuefeng; Gong, Chen; He, Lin; Hong, Junhao; Wu, Songsong; Jin, Xin

doi:10.1016/j.exger.2014.12.017

Cited by 31 publications

(22 citation statements)

References 33 publications

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“…In the current study, to confirm the hypolipidemic effect of HDT in vivo , acute hyperlipidemia mouse model was established using Triton WR‐1339, a lipoprotein lipase inhibitor (Zhao et al ., ). HDT pretreatment protected against the increase of serum total cholesterol, TG, LDL‐C, and phospholipid in an acute hyperlipidemia mouse model with enhancement of glutathione reductase, glutathione peroxidase, catalase, and SOD activity, indicating anti‐fatty liver potential of HDT through its hypolipidemic effect, because hyperlipidemia is closely associated with fatty liver (Assy et al ., ).…”

Section: Discussionmentioning

confidence: 99%

Hovenia Dulcis Extract Reduces Lipid Accumulation in Oleic Acid‐Induced Steatosis of Hep G2 Cells via Activation of AMPK and PPARα/CPT‐1 Pathway and in Acute Hyperlipidemia Mouse Model

Kim

Woo

Park

et al. 2016

Phytotherapy Research

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Hovenia dulcis Thunb. (HDT) was known to have anti-fatigue, anti-diabetes, neuroprotective, and hepatoprotective effects. In the present study, the anti-fatty liver mechanism of HDT was elucidated in oleic acid (OA)-treated Hep G2 cells and acute hyperlipidemia mouse model using Triton WR-1339. Here, HDT activated p-AMP-activated protein kinase (p-AMPK), proliferator activated receptor-α, carnitine palmitoyltransferase and also inhibited the expression of lipogenesis and cholesterol synthesis proteins, such as 3-hydroxy-3-methylglutaryl-CoA reductase, sterol regulatory element binding protein-1c, SREBP-2, and fatty acid synthase in OA-treated Hep G2 cells. Conversely, AMPK inhibitor compound C blocked the anti-fatty liver effect of HDT to induce AMPK phosphorylation and decrease 3-hydroxy-3-methylglutaryl-CoA reductase and lipid accumulation by oil red O staining in OA-treated Hep G2 cells. Additionally, HDT pretreatment protected against the increase of serum total cholesterol, triglyceride, low-density lipoprotein cholesterol and phospholipid in an acute hyperlipidemia mouse model with enhancement of glutathione reductase, glutathione peroxidase, superoxide dismutase, and catalase activities. Taken together, HDT inhibits OA-induced hepatic lipid accumulation via activation of AMPK and proliferator activated receptor-α/carnitine palmitoyltransferase signaling and enhancement of antioxidant activity as a potent candidate for nonalcoholic fatty liver disease and hyperlipidemia. Copyright © 2016 John Wiley & Sons, Ltd.

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Section: Discussionmentioning

confidence: 99%

Hovenia Dulcis Extract Reduces Lipid Accumulation in Oleic Acid‐Induced Steatosis of Hep G2 Cells via Activation of AMPK and PPARα/CPT‐1 Pathway and in Acute Hyperlipidemia Mouse Model

Kim

Woo

Park

et al. 2016

Phytotherapy Research

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“…This amount was two times higher than that in ultrasonic process, as well as that in the other reported results in the range of 100-400 mg/100 g [23,24]. This result indicates that the UE may play an important role in improving the extraction yield of wedelolactone because of the minimal destruction of heat-labile wedelolactone caused by the low temperature extraction process, even at low temperature [25].…”

Section: Wedelolactone Contents and Antioxidant Activities Of The Extmentioning

confidence: 47%

Enhancement of Skin Anti-Inflammatory Activities of Eclipta prostrata L. from the Ultrasonic Extraction Process

Lee

2017

Applied Sciences

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This work first showed that the skin anti-inflammatory activities of Eclipta prostrata L. (E. prostrata L.)n be increased through an ultrasonic extraction process at a frequency of 120 kHz with 70% ethanol at 40 • C for 6 h. The extract from the ultrasound extraction (UE) contained 378.6 mg/100 g of wedelolactone (a major bioactive substance in E. prostrata L.), compared with the 172.9 mg/100 g from a conventional extraction process with 70% ethanol at 80 • C for 12 h (EE). The UE showed less than 10% of low cytotoxicity against normal fibroblast cells, and also exhibited much higher antioxidant activities than that from the EE when treating with 0.3 mg/mL of the extracts. It was proved that the high antioxidant activities of the UE were closely correlated with the enhancement of skin anti-inflammatory activities by effectively suppressing the production of tumor necrosis factor-alpha and interleukin-6 from macrophages. The production of prostaglandin E 2 from human skin cells was also greatly reduced, compared with the EE for all ranges of the treatments. These results strongly indicate that the various biological activities of E. prostrata L. can be improved by a simple ultrasound extraction process because of the high elution of bioactive substances even at a low temperature.

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“…For example, Chan et al found that the water extract of E. prostrata had antioxidant effects, and Ryu et al used the cells of RAW 264.7 macrophages to clarify that the anti‐inflammatory and antioxidant properties of E. prostrata extract were related to the expressions of iNOS, TNF‐α, and IL‐6 . Additionally, animal experiments revealed that E. prostrata extract has hypolipidemic effects . Moreover, E. prostrata extract plays a crucial role effects such as protective effects of bleomycin‐induced pulmonary fibrosis and inhibition of the proliferation of hepatic stellate cells .…”

Section: Introductionmentioning

confidence: 99%

Antimetastatic effects of Eclipta prostrata extract on oral cancer cells

Liao

Chuang

Hsieh

et al. 2018

Environmental Toxicology

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Eclipta prostrata, a traditional Chinese medication, has been used for the treatment of several diseases. However, the molecular mechanism underlying the effects of Eclipta prostrata extracts (EPE) on human oral cancer cell metastasis remains unclear. We thus examined the effects of EPE on metastasis promoting proteins in oral cancer. Our results revealed that the EPE attenuated SCC-9, HSC-3, and TW2.6 cell migration and invasiveness by reducing matrix metalloproteinase (MMP)-2 enzyme activities. In addition, Western blot analysis revealed that EPE significantly reduced the levels of phosphorylated extracellular signal-regulated kinase 1/2 (ERK 1/2) but not those of c-Jun N-terminal kinase (JNK) 1/2 and p38. In conclusion, we found that EPE could inhibit oral cancer metastasis through the inhibition of MMP-2 expression. Therefore, EPE may be used to prevent the metastasis of oral cancer, and has the potential to be applied to cancer treatment.

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Effect of Eclipta prostrata on lipid metabolism in hyperlipidemic animals

Cited by 31 publications

References 33 publications

Hovenia Dulcis Extract Reduces Lipid Accumulation in Oleic Acid‐Induced Steatosis of Hep G2 Cells via Activation of AMPK and PPARα/CPT‐1 Pathway and in Acute Hyperlipidemia Mouse Model

Hovenia Dulcis Extract Reduces Lipid Accumulation in Oleic Acid‐Induced Steatosis of Hep G2 Cells via Activation of AMPK and PPARα/CPT‐1 Pathway and in Acute Hyperlipidemia Mouse Model

Enhancement of Skin Anti-Inflammatory Activities of Eclipta prostrata L. from the Ultrasonic Extraction Process

Antimetastatic effects of Eclipta prostrata extract on oral cancer cells

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