Effect of Electroacupuncture on Natural-Killer Cells and Tumor Size in Patients with Cervical Squamous-Cell Carcinoma: A Randomized Controlled Trial

Saraswati, Wita; Dahlan, Erry Gumilar; Saputra, Koosnadi; Sutrisno, Thomas Cahyono

doi:10.1089/acu.2018.1316

Cited by 19 publications

(19 citation statements)

References 26 publications

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“…They showed how EA increases the number of NK cells in peripheral blood, infiltrates the tumour, and increases granzyme B and perforin in the tumour tissue. These findings suggest that EA could be a complementary alternative in cancer treatment, however, more studies are required [93][94][95].…”

Section: Treatments That Enhance Nk Cell Activitymentioning

confidence: 90%

NK Cell Regulation in Cervical Cancer and Strategies for Immunotherapy

Gutiérrez‐Hoya

Soto‐Cruz²

2021

Cells

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Cervical cancer is one of the most prevalent gynaecological malignancies worldwide and is related to human papillomavirus (HPV) infection, viral persistence, progression, and invasion. Therefore, the immune response is linked to HPV status. Natural killer (NK) cells play a central role against virus-infected cells and tumours through a delicate balance between activating and inhibitory receptors and secretion of cytokines and chemokines. These cells also play a crucial role in tumour immunosurveillance. For these reasons, there is growing interest in harnessing NK cells as an immunotherapy for cervical cancer. These studies are diverse and include many strategies such as transferring activated autologous or allogeneic NK cells, improving the activation and cytolytic activity of NK cells using cytokines or analogues and modifying chimeric antigen receptors to increase specificity and targeting NK cells. However, research regarding the application of NK cells in immunotherapy is limited. This article focuses on recent discoveries about using NK cells to prevent and treat cervical cancer and the possibility of cellular immunotherapy becoming one of the best strategies to exploit the immune system to fight tumours.

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Section: Treatments That Enhance Nk Cell Activitymentioning

confidence: 90%

NK Cell Regulation in Cervical Cancer and Strategies for Immunotherapy

Gutiérrez‐Hoya

Soto‐Cruz²

2021

Cells

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“…1). 1‐134 Of those, 65 of 94 publications (69.1%) were included in the qualitative analysis because they reported at least 1 type of AE,…”

Section: Resultsmentioning

confidence: 99%

“…Of those, 65 of 94 publications (69.1%) were included in the qualitative analysis because they reported at least 1 type of AE, 15 (16%) did not report any type of safety-related data, [108][109][110][111][112][113][114][115][116][117][118][119][120][121][122] and 14 (14.9%) had insufficient or contradictory data. 118,[123][124][125][126][127][128][129][130][131][132][133][134][135] Only 14 studies (14.9%) reported data on all 4 categories of AEs. Three studies concerning crossover trials reported insufficient data for inclusion in the meta-analyses.…”

Section: Literature Searchmentioning

confidence: 99%

Safety of acupuncture in oncology: A systematic review and meta‐analysis of randomized controlled trials

Höxtermann

Haller

Aboudamaah

et al. 2022

Cancer

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Background Acupuncture is frequently used to treat the side effects of cancer treatment, but the safety of this intervention remains uncertain. The current meta‐analysis was conducted to assess the safety of acupuncture in oncological patients. Methods The PubMed, Cochrane Central Register of Controlled Trials, and Scopus databases were searched from their inception to August 7, 2020. Randomized controlled trials in oncological patients comparing invasive acupuncture with sham acupuncture, treatment as usual (TAU), or any other active control were eligible. Two reviewers independently extracted data on study characteristics and adverse events (AEs). Risk of bias was assessed using the Cochrane Risk of Bias Tool. Results Of 4590 screened articles, 65 were included in the analyses. The authors observed that acupuncture was not associated an with increased risk of intervention‐related AEs, nonserious AEs, serious AEs, or dropout because of AEs compared with sham acupuncture and an active control. Compared with TAU, acupuncture was not associated with an increased risk of intervention‐related AEs, serious AEs, or drop out because of AEs but was associated with an increased risk for nonserious AEs (odds ratio, 3.94; 95% confidence interval, 1.16‐13.35; P = .03). However, the increased risk of nonserious AEs compared with TAU was not robust against selection bias. The meta‐analyses may have been biased because of the insufficient reporting of AEs in the original randomized controlled trials. Conclusions The current review indicates that acupuncture is as safe as sham acupuncture and active controls in oncological patients. The authors recommend researchers heed the CONSORT (Consolidated Standards of Reporting Trials) safety and harm extension for reporting to capture the side effects and better investigate the risk profile of acupuncture in oncology. Lay Summary According to this analysis, acupuncture is a safe therapy for the treatment of patients with cancer. Acupuncture seems to be safe compared with sham acupuncture and active controls.

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“…One clinical trial indicated that after 4 cycles of chemotherapy on cervical squamous cell carcinoma at stages Ⅱb-шb, NK cells increased and tumor size reduced. 65 Another study added evidence to this discovery, reporting that NK cells were significantly associated with improved prognosis. 66…”

Section: Nk Cellsmentioning

confidence: 95%

<p>Cervical Cancer: Emerging Immune Landscape and Treatment</p>

Guo¹,

Hua²

2020

OTT

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Immune cells are essential for defending the body's balance and have increasingly been implicated in controlling tumor growth. In cervical cancer (CC), the immune landscape is extensively connected with human papillomavirus (HPV) status. Recent insights from studies have revealed that as a result of infection with HPV, immune cell populations such as lymphocytes or monocytes change during carcinogenesis. Immune therapy, in particular checkpoint inhibitors, those targeting PD-1 or PD-L1, has shown promising efficacy. This article reviews the immune landscape and immunotherapy of CC.

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Effect of Electroacupuncture on Natural-Killer Cells and Tumor Size in Patients with Cervical Squamous-Cell Carcinoma: A Randomized Controlled Trial

Cited by 19 publications

References 26 publications

NK Cell Regulation in Cervical Cancer and Strategies for Immunotherapy

NK Cell Regulation in Cervical Cancer and Strategies for Immunotherapy

Safety of acupuncture in oncology: A systematic review and meta‐analysis of randomized controlled trials

<p>Cervical Cancer: Emerging Immune Landscape and Treatment</p>

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