Effect of Elevated Intracranial Pressure on Amplitudes and Frequency Tuning of Ocular Vestibular Evoked Myogenic Potentials Elicited by Bone-Conducted Vibration

Gürkov, Robert; Speierer, Guillaume; Wittwer, Luis; Kalla, Roger

doi:10.1097/aud.0000000000000326

Cited by 5 publications

(5 citation statements)

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“…Reduction in ICP by lumbar cerebrospinal fluid (CSF) drainage has a systemic effect on VEMP amplitudes. Increasing ICP systematically alters oVEMP in terms of absolute amplitudes and frequency tuning characteristics (36)(37)(38)(39). In this report, in terms of differences in oVEMP parameters between children with EVA and those with a normal cochlea, we speculated that the presence of a third window in the inner ear labyrinth might allow for activation of vestibular receptors in LVAS patients (40).…”

Section: Discussionmentioning

confidence: 71%

Influence of Cochlear Implantation on Vestibular Function in Children With an Enlarged Vestibular Aqueduct

et al. 2021

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Background: Cochlear implantation (CI) is becoming increasingly used in the rehabilitation of hearing-impaired patients. Children with an enlarged vestibular aqueduct (EVA) need CI for severe or profound hearing loss, with excellent outcomes in hearing rehabilitation. However, vestibular function influenced by CI in children with EVA has not been clarified. We compared the characteristics of vestibular function in implanted children with EVA and those with a normal cochlea.Methods: In this retrospective case-control study, 16 children with large vestibular aqueduct syndrome (LVAS) and 16 children with a normal cochlea were recruited as the Study and Control Group, respectively. All children (mean age, 10.3 ± 4.4 years) had bilateral profound sensorineural hearing loss (SNHL) and normal pre-operative vestibular functions and underwent unilateral CI. Otolith and canal functions were assessed before CI and 12 months thereafter. Cervical vestibular-evoked myogenic potential (cVEMP), ocular vestibular-evoked myogenic potential (oVEMP), and video head impulse test (vHIT) were evaluated.Results: Full insertion of the electrode array was achieved in all the cases. Preoperatively, no significant differences in parameters in cVEMP between the Study and Control Group were revealed (p > 0.05). In pre-operative oVEMP, shorter N1 latencies (p = 0.012), shorter P1 latencies (p = 0.01), and higher amplitudes (p = 0.001) were found in the Study than in the Control Group. The Study Group had shorter P1 latency in cVEMP (p = 0.033), and had lower amplitude in oVEMP after implantation (p = 0.03). Statistically significant differences were not found in VOR gains of all three semicircular canals before and after surgery (p > 0.05). VEMP results revealed that the Control Group had significantly lower deterioration rates after CI (p < 0.05). The surgical approach and electrode array had no statistically significant influence on the VEMP results (p > 0.05).Conclusion: oVEMP parameters differed between children with EVA and children with a normal cochlea before surgery. Systematic evaluations before and after CI showed that otolith function was affected, but all three semicircular canals functions were essentially undamaged after implantation. In contrast to subjects with a normal cochlea, children with EVA are more likely to preserve their saccular and utricular functions after CI surgery. Possible mechanisms include less pressure-related damage, a reduced effect in terms of the air-bone gap (ABG), or more sensitivity to acoustic stimulation.

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Section: Discussionmentioning

confidence: 71%

Influence of Cochlear Implantation on Vestibular Function in Children With an Enlarged Vestibular Aqueduct

et al. 2021

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“…The chemical composition of endolymph in XLH could be altered by varied aural expression of ion channels [240] or through metabolic interactions with the surrounding phosphate-deprived bone [230]. A disrupted chemical composition could also be linked to aural precipitates that have been observed in various animal models of XLH [77, 242]. Characterising the endolymphatic fluid and any precipitate in XLH patients would shed light on this matter.…”

Section: Background and Introductionmentioning

confidence: 99%

FGF23 and its role in X-linked hypophosphatemia-related morbidity

Beck-Nielsen

Mughal

Haffner

et al. 2019

Orphanet J Rare Dis

196

229

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Background X-linked hypophosphatemia (XLH) is an inherited disease of phosphate metabolism in which inactivating mutations of the Phosphate Regulating Endopeptidase Homolog, X-Linked ( PHEX ) gene lead to local and systemic effects including impaired growth, rickets, osteomalacia, bone abnormalities, bone pain, spontaneous dental abscesses, hearing difficulties, enthesopathy, osteoarthritis, and muscular dysfunction. Patients with XLH present with elevated levels of fibroblast growth factor 23 (FGF23), which is thought to mediate many of the aforementioned manifestations of the disease. Elevated FGF23 has also been observed in many other diseases of hypophosphatemia, and a range of animal models have been developed to study these diseases, yet the role of FGF23 in the pathophysiology of XLH is incompletely understood. Methods The role of FGF23 in the pathophysiology of XLH is here reviewed by describing what is known about phenotypes associated with various PHEX mutations, animal models of XLH, and non-nutritional diseases of hypophosphatemia, and by presenting molecular pathways that have been proposed to contribute to manifestations of XLH. Results The pathophysiology of XLH is complex, involving a range of molecular pathways that variously contribute to different manifestations of the disease. Hypophosphatemia due to elevated FGF23 is the most obvious contributor, however localised fluctuations in tissue non-specific alkaline phosphatase (TNAP), pyrophosphate, calcitriol and direct effects of FGF23 have been observed to be associated with certain manifestations. Conclusions By describing what is known about these pathways, this review highlights key areas for future research that would contribute to the understanding and clinical treatment of non-nutritional diseases of hypophosphatemia, particularly XLH.

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“…The literature regarding Altered frequency dynamics of oVEMP was carried out in normal individuals (Janky & Shepard, 2009), Meniere's disease (Singh & Barman, 2016), Semi-circular canal dehiscence (Zhang et al, 2012) and elevated intracranial pressure individuals (Gürkov et al, 2016). Several researches have revealed an association between diabetes mellitus and vestibular dysfunction;…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Altered Frequency Dynamics of Ocular-Vestibular Evoked Myogenic Potentials in Type 2 Diabetes Mellitus

Seshagiri,

Purushothaman,

Thirunavukkarasu

et al. 2024

Audiol Speech Res

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Purpose: The study aims to address the gap in understanding the relationship between type 2 diabetes mellitus (T2DM) and vestibular dysfunction, particularly focusing on how T2DM may affect the tuning of the vestibular system. Specifically, the investigation aims to explore the impact of stimulus parameters, particularly stimulus frequency, on ocular vestibular evoked myogenic potentials (oVEMP) in individuals with T2DM.Methods: A case-control study design was used, utilizing non-probability sampling. All participants underwent routine audiological and vestibular evaluations before inclusion in the study. oVEMP’s were compared across 40 healthy individuals (group A) and 40 individuals with T2DM (group B) at 500 Hz, 1 KHz, and 2 KHz.Results: In group A, all 80 participants exhibited oVEMP responses across all frequencies in both ears, while in group B, consisting of individuals with T2DM, response rates were slightly lower, ranging from 70% to 77.5% across frequencies. Statistical analysis revealed significant amplitude differences at all frequencies tested in type 2 diabetic ears compared to healthy ears, although amplitude remained consistent within type 2 diabetic ears. Latencies (first negative [N1] and first positive [P1]) were consistent across groups, with delays observed in P1 latency, particularly noticeable at higher frequencies, both in healthy and type 2 diabetic ears. Gender didn't affect oVEMP frequency dynamics in any of the groups.Conclusion: Diabetes may create an impact in the functioning of otolith organs, the vestibular branch of eighth cranial nerve, and their innervations. VEMP evaluates both the sacculo-collic and utriculo-ocular pathways to detect changes in the functions of vestibular organs. Therefore, it's crucial to consider diabetes when conducting vestibular diagnosis or treatment.

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Effect of Elevated Intracranial Pressure on Amplitudes and Frequency Tuning of Ocular Vestibular Evoked Myogenic Potentials Elicited by Bone-Conducted Vibration

Cited by 5 publications

References 20 publications

Influence of Cochlear Implantation on Vestibular Function in Children With an Enlarged Vestibular Aqueduct

Influence of Cochlear Implantation on Vestibular Function in Children With an Enlarged Vestibular Aqueduct

FGF23 and its role in X-linked hypophosphatemia-related morbidity

Efficacy of Altered Frequency Dynamics of Ocular-Vestibular Evoked Myogenic Potentials in Type 2 Diabetes Mellitus

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