Effect of end-block chain length on rheological properties of ABA triblock copolymer hydrogels

Jung, Hyunjoon; Earmme, Taeshik; Choi, Soo-Hyung

doi:10.1007/s13367-021-0011-3

Cited by 3 publications

(1 citation statement)

References 36 publications

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“…[ 38 ] It was verified that a physical hydrogel of ABA triblock copolymer with polyether endblock, which has similar hydrophobicity and molecular weight ( M n = 6.0 kDa) to those of PCL in the present work, has a relaxation time in order of 10 13 s solely based on the chain pull‐out kinetics. [ 39 ] The pull‐out time of PCL is likely close to this timescale, therefore, the PCL chain dynamics will not contribute to the observed hydrogel relaxation. Second, the PCBMA block is fully hydrated, so its relaxation is much faster than that of P(PEGMA‐UPy 0.15 ) block.…”

Section: Resultsmentioning

confidence: 99%

Antifreeze and Rheological Properties of Injectable Triblock Copolymer Hydrogels with Supramolecular Junctions

Choi

Kim

Mun

et al. 2021

Macromol. Rapid Commun.

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ABC triblock copolymers composed of hydrophobic poly(𝝐-caprolactone) (PCL), zwitterionic poly(carboxybetaine methacrylate) midblock, and P(PEGMA-UPy 0.15 ) containing supramolecular ureidopyrimidinone moieties, poly(𝝐-caprolactone-block-carboxybetaine methacrylate-block-[poly(ethylene glycol) methyl ether methacrylate-co-(𝜶-methacryloyl-𝝎-(6-(3-(6-methyl-4-oxo-1,4-dihydropyrimidin-2-yl)ureido)hexylcarbamoyloxy)poly(ethylene glycol))]), are investigated to achieve multifunctional antifreeze hydrogels. The PCL and P(PEGMA-UPy 0.15 ) blocks induce the formation of physical network with a hierarchical nanostructure comprising hydrophobic PCL cores and supramolecular junctions, respectively. The super-hydrophilic nature of polyzwitterion midblocks and the confinement effect of the supramolecular junctions enhance the antifreeze performance, where the majority of water molecules remains supercooled below sub-zero temperature. The hydrogel relaxation characterized over a wide range of timescale reveals that the facile dynamics of the supramolecular junctions lead to the self-healing and injectability of the hydrogels. In conjunction with the biodegradable PCL cores, the antifreeze and rheological characteristics of the triblock copolymer hydrogels provide significant potential to use for cryo-preservable and bio-injectable drug storage and delivery.

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Section: Resultsmentioning

confidence: 99%

Antifreeze and Rheological Properties of Injectable Triblock Copolymer Hydrogels with Supramolecular Junctions

Choi

Kim

Mun

et al. 2021

Macromol. Rapid Commun.

View full text Add to dashboard Cite

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Cubosomes: An emerging nanodrug delivery platform for anti-diabetic medications

Garg,

Vyas,

Arivarasan

et al. 2024

Journal of Drug Delivery Science and Technology

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Cubosomes as Potential Nanocarrier for Drug Delivery: A Comprehensive Review

Kaur

Singh

et al. 2021

JPRI

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Lyotropic liquid crystalline cores are characterized as soft nanoparticles and referred as cubosomes. They are prepared to activate the natural self-assembly capability of lipids (e.g., monoolein or phytantriol) in water. Cubosomes are crystalline isotropic lipidic nanoparticles stabilized by Poloxamers such as F127, F108. It is made up of a network of two separate aqueous channels formed by a three-dimensional, non-intersecting lipid bilayer imposed over an indefinite periodic minimum surface of cubic symmetry. Cubosomes constitute unique features such as their special cubic structure which permits to incorporate highly lipophilic, hydrophilic, and amphiphilic drugs. Also, the lipids excipients used in the preparation of cubosomes such as monoolein, phytantriol are biodegradable and biocompatible so these cubic nanoparticles are referred as safe carrier for drug delivery. Cubic lipid nanoparticles have a highly stable cubic shape that allows for a slower rate of dissociation, improved drug retention, and site-specific drug delivery. The architecture of cubic particles provides suitability in the drug delivery as compared to other lipids-based drug delivery systems such as solid lipid nanoparticles (SLN), liposomes due to their drug expulsion to the surface of nanoparticles. Cubosomes with these loaded features/architectural composition led to an array of desired performance. Solvent evaporation, ultrasonication, hydrotrope, spray drying, melt dispersion emulsifying methods are used to prepare these carrier systems.

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Effect of end-block chain length on rheological properties of ABA triblock copolymer hydrogels

Cited by 3 publications

References 36 publications

Antifreeze and Rheological Properties of Injectable Triblock Copolymer Hydrogels with Supramolecular Junctions

Antifreeze and Rheological Properties of Injectable Triblock Copolymer Hydrogels with Supramolecular Junctions

Cubosomes: An emerging nanodrug delivery platform for anti-diabetic medications

Cubosomes as Potential Nanocarrier for Drug Delivery: A Comprehensive Review

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