Effect of Endurance Training with Royal Jelly on CRP Gene Expression in Muscle Tissue of Rats with Alzheimer ’s Disease

Noura, Mehdi; Arshadi, Sajjad; Zafari, Ardeshir; Banaeyfar, Abdolali

doi:10.5812/mejrh.99754

Cited by 6 publications

(4 citation statements)

References 24 publications

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“…Royal jelly contains important compounds such as proteins, sugars, lipids, amino acids, vitamins and minerals; It also has a wide range of medicinal functions such as antioxidant, anti-edematous, antimicrobial, anti-allergic and anti-tumor properties and protective effects on immune, inflammatory and nervous systems (21). Nora et al (2020) reported a significant decrease in CRP as a result of eight weeks of endurance training and consumption of royal jelly (100 mg/kg) in the muscle tissue of rats with Alzheimer's disease (22).…”

Section: Discussionmentioning

confidence: 99%

The effect of a period of Pilates and the supplementation of Royal Jelly on inflammatory indexes of diabetic obese women

Romuzi¹

2023

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Background: The use of supplements, herbal extracts, and exercise training for the treatment of diseases and metabolic disorders has increased among people. Thus, the aim of this study was the study of The effect of a period of Pilates and the supplementation of Royal Jelly on inflammatory indexes of diabetic obese women. Materials and Methods:In this quasi-experimental study 44 volunteer diabetic obese women participated and They were randomly divided into Four groups of 11 controls, Royal Jelly, Pilates, Pilates + Royal Jelly . Pilates exercise training was performed during 8 weeks (3 sessions per week, 60 min per session). The subjects consumed a supplement group of 1000 mg of royal Jelly daily for 8 weeks. covariance analysis test were used to examine the in-group differences and between the research groups. Results:The results showed that eight weeks of Pilates and Royal Jelly Supplements significantly reduced the TNF-α, CRP and IL-6 diabetic women(P=0.001). In addition, serum glucose and serum insulin also decreased significantly in during eight weeks of Pilates and supplementation of the royal Jelly(P=0.001). Vo2max significantly Increase in training, training + supplement groups (P=0.001). Conclusion:According to obtained results, it appears that Pilates training plus Royal Jelly extract consumption have better effect on serum inflammatory factors in obsess women with diabetes type 2

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Section: Discussionmentioning

confidence: 99%

The effect of a period of Pilates and the supplementation of Royal Jelly on inflammatory indexes of diabetic obese women

Romuzi¹

2023

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“…In another study, researchers showed that the use of RJ by cAMP/PKA/CREB/BDNF mechanism inhibits nerve cell apoptosis and reduces DNA damage (17). Although in previous studies, the favorable interactive effects of training and RJ consumption on neurotrophins (15), cognitive function (11), and inflammatory factors (9) have been reported, the exact mechanism of these two in-terventions on the pathways for DNA repair and transcription of metabolism-related genes (ATPase) are not yet fully understood.…”

Section: Introductionmentioning

confidence: 97%

“…Researchers have reported beneficial effects of aerobic exercise on the mental, physical and cognitive health of patients with AD, the intensity, duration of activity, and the most effective duration of exercise, as well as the type of exercise based on differences in contraction and related adaptations, are not yet fully understood (8). In this regard, the results showed that endurance training reduced C-reactive protein in the muscle tissue of AD rats (9). In addition, endurance training on different slopes has been one of the challenges in assessing the type of adaptation in the cognitive function of AD animal models.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Eight Weeks of Training on Positive and Negative Slopes with Royal Jelly Consumption on MGMT and ATPase Gene Expression Levels in the Hippocampus Tissue of Trimethyltin-Induced Alzheimer’s Rats

et al. 2021

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Background: Alzheimer’s disease (AD) is a common disease in the elderly that is associated with impaired metabolism and biology of the hippocampus. Although the role of exercise and natural antioxidants in improving the disease has been reported, the role of muscle contraction-related physical activity along with royal jelly (RJ) consumption is not yet well understood. Objectives: This study aimed to investigate the effect of eight weeks of training on positive slope (ETPS) and negative slope (ETNS) with royal jelly (RJ) consumption on O-6-methylguanine DNA methyltransferase (MGMT) and ATPase gene expression levels in the hippocampus tissue of trimethyltin (TMT)-induced AD rats. Methods: In this experimental trial, 36 male Sprague-Dawley AD rats (induced with 8 mg/kg TMT) were divided into (1) control + normal saline/royal jelly solvent) (Sh); (2) ETPS; (3) ETNS; (4) ETPS + RJ; (5) ETNS + RJ, and (6) RJ groups. Six rats were placed in the healthy control (HC) group. Then the training groups trained on ( + 15 and -15) slopes for eight weeks, five sessions per week, and each session lasted 60 minutes at a speed of 16 m/min. The royal jelly (RJ) groups received 100 mg/kg royal jelly per day by intraperitoneal injection. Results: ETNS, ETPS, ETPS + RJ, and ETNS + RJ increased MGMT gene expression (P ≥ 0.05). ETPS and ETPS + RJ also increased ATPase gene expression (P ≥ 0.05). However, RJ had no significant effect on increasing MGMT and ATPase gene expression in the hippocampus tissue of AD rats (P ≥ 0.05). Conclusions: It seems that the improvement of DNA damage markers and energy levels depends on the type of contraction. Although training on positive and negative slopes with royal jelly consumption has an interactive effect on DNA repair markers, training on a positive slope and royal jelly consumption has an interactive effect on ATPase gene expression.

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“…3,4 Considering the increasing prevalence of cognitive and metabolic disorders in the elderly population, it is important to provide them with effective treatment strategies. Therefore, the positive role of exercise training in improving cognitive function, 5 improving balance and muscle strength, 6 reducing inflammatory factors in skeletal muscle tissue, 7 reducing oxidative stress in cerebral arteries 8 and improving cardiac function has been reported in AD patients. 9 Exercise training with the mechanism of increasing cyclic adenosine monophosphate (cAMP) leads to the phosphorylation of protein kinase A (PKA), and activation of protein kinase activated by cAMP (AMPK) leads to the phosphorylation of PGC1α, increased nuclear transcription, mitochondrial proliferation, recovery of substrate metabolism in skeletal and cardiac muscle, and ultimately weight loss.…”

mentioning

confidence: 99%

Changes in Some Observational Cardiac Parameters and Cardiac PGC1-α Expression Following Eight Weeks of Endurance Training and Saffron Consumption in Animal Models of Alzheimer’s Disease

Azariyan

Keshavarz

Hosseini

et al. 2022

Int J Basic Sci Med

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Introduction: The link between Alzheimer’s disease (AD) and heart disease has recently been reported. Previous studies have reported the beneficial role of endurance training (ET) and saffron (Sa) on the heart and nervous system health, but their interactive effect is not yet well known. Therefore, the aim of this study was to determine changes in some observational cardiac parameters and cardiac PGC1-α expression after 8 weeks of ET and Sa consumption in animal models of AD. Methods: In this experimental trial, 40 rats with AD (by intraperitoneal injection of 8 mg/kg neurotoxin trimethyltin) were divided into (1) AD, (2) sham (Sh), (3) Sa, (4) ET, and (5) ET+Sa groups. Additionally, to evaluate the effect of AD induction on the research variables, 8 healthy rats were included in the healthy control (HC) group. Groups 4 and 5 ran for 8 weeks, three 15-30 minute sessions per week at a speed of 20-15 m/min. Groups 3 and 5 received 25 mg/ kg aqueous extract of Sa peritoneally each day. To analyze the data, dependent samples t test, one-way analysis of variance and Tukey’s post hoc test, analysis of covariance with Bonferroni’s post hoc test in SPSS version 22.0 were used (P≥0.05). Results: In the Sa and ET+Sa groups, heart weight, heart weight to body weight ratio, and cardiac PGC1-α expression were higher and the body weight of these groups was significantly lower compared with the AD group (P≤0.05). Moreover, in the ET group, heart weight was higher than body weight and total body weight was lower compared to the AD group (P≤0.05). Conclusion: It seems that Sa and ET+Sa interaction improve heart function and some parameters related to heart health by increasing PGC1-α expression, but the effect of training depends on its type and intensity, which should be further studied.

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Effect of Endurance Training with Royal Jelly on CRP Gene Expression in Muscle Tissue of Rats with Alzheimer ’s Disease

Cited by 6 publications

References 24 publications

The effect of a period of Pilates and the supplementation of Royal Jelly on inflammatory indexes of diabetic obese women

The effect of a period of Pilates and the supplementation of Royal Jelly on inflammatory indexes of diabetic obese women

The Effect of Eight Weeks of Training on Positive and Negative Slopes with Royal Jelly Consumption on MGMT and ATPase Gene Expression Levels in the Hippocampus Tissue of Trimethyltin-Induced Alzheimer’s Rats

Changes in Some Observational Cardiac Parameters and Cardiac PGC1-α Expression Following Eight Weeks of Endurance Training and Saffron Consumption in Animal Models of Alzheimer’s Disease

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