Effect of estrogen on bone resorption and inflammation in the temporomandibular joint cellular elements

Galal, Nadia; Beialy, Waleed El; Deyama, Yoshiaki; Yoshimura, Yoshitaka; Yoshikawa, Takahiro; Suzuki, Kuniaki; Totsuka, Yasunori

doi:10.3892/ijmm.21.6.785

Cited by 15 publications

(18 citation statements)

References 26 publications

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“…The study used mouse chondrogenic ATDC5 cells, which are an excellent in vitro model for studying the regulation of endochondral bone growth as they undergo similar differentiation processes with chondroprogenitor cells in the growth plates fully differentiating into hypertrophic chondrocytes in the presence of insulin (Snelling et al 2010). The findings that both ERs and OBRs are expressed in ATDC5 cells (Kishida et al 2005, Galal et al 2008) also suggest that ATDC5 cells are an appropriate model for studying the cross talk between leptin and estrogen. In our previous study (Wang et al 2011), we found that both ERa and ERb were dynamically expressed during the ATDC5 cell differentiation from 4 to 21 days.…”

Section: Introductionmentioning

confidence: 99%

Estrogen stimulates leptin receptor expression in ATDC5 cells via the estrogen receptor and extracellular signal-regulated kinase pathways

Wang

Li²,

Jiang³

et al. 2012

Journal of Endocrinology

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Regulation of the physiological processes of endochondral bone formation during long bone growth is controlled by various factors including the hormones estrogen and leptin. The effects of estrogen are mediated not only through the direct activity of estrogen receptors (ERs) but also through cross talk with other signaling systems implicated in chondrogenesis. The receptors of both estrogen and leptin (OBR (LEPR)) are detectable in growth plate chondrocytes of all zones. In this study, the expression of mRNA and protein of OBR in chondrogenic ATDC5 cells and the effect of 17b-estradiol (E 2 ) stimulation were assessed using quantitative PCR and western blotting. We have found that the mRNA of Obr was dynamically expressed during the differentiation of ATDC5 cells over 21 days. Application of E 2 (10 K7 M) at day 14 for 48 h significantly upregulated OBR mRNA and protein levels (P!0 . 05). The upregulation of Obr mRNA by E 2 was shown to take place in a concentration-dependent manner, with a concentration of 10 K7 M E 2 having the greatest effect. Furthermore, we have confirmed that E 2 affected the phosphorylation of ERK1/2 (MAPK1/MAPK3) in a time-dependent manner where a maximal fourfold change was observed at 10 min following application of E 2 . Finally, pretreatment of the cells with either U0126 (ERK1/2 inhibitor) or ICI 182 780 (ER antagonist) blocked the upregulation of OBR by E 2 and prevented the E 2 -induced phosphorylation of ERK. These data demonstrate, for the first time, the existence of cross talk between estrogen and OBR in the regulation of bone growth whereby estrogen regulates the expression of Obr in growth plate chondrocytes via ERs and the activation of ERK1/2 signaling pathways.

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Section: Introductionmentioning

confidence: 99%

Estrogen stimulates leptin receptor expression in ATDC5 cells via the estrogen receptor and extracellular signal-regulated kinase pathways

Wang

Li²,

Jiang³

et al. 2012

Journal of Endocrinology

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“…87 It has been shown that 17␤-estradiol has a positive effect on OPG transcription and an inhibitory effect on TNF-␣ liberation. 88,89 We have previously reported on the presence of estrogen imbalance in a group of female patients with severe condylar resorption. 13 Evidence also suggests that nutritional status may be an important determinant of an individual's susceptibility to degenerative TMJ disease.…”

Section: Susceptibility To Condylar Resorptionmentioning

confidence: 98%

Pathophysiology and Pharmacologic Control of Osseous Mandibular Condylar Resorption

Gunson¹,

Arnett²,

Milam³

2012

Journal of Oral and Maxillofacial Surgery

134

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“…Diagnosis and the cure of TMJOA is complex and mixed because the disease is accompanied with synovitis, apticular capsulitis, anterior disc displacement and perforation of articular disc 5,6) . Wikes stages are determined by the placement and morphology of the articular disc and the bone destruction of hip process shown in TMJ MRI 7) .…”

Section: Discussionmentioning

confidence: 99%

Investigation of Characteristic Indeices Related to Temporomandibular Joint Osteoarthrosis

Zhou

Ueno

et al. 2013

J. Hard Tissue Biology.

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The purpose of this study was to investigate the relationship between the bone mineral density and the contents of osteocalcin calcium and phosphorus in serum with temporomandibular joint osteoarthrosis (TMJOA). The mineral densities of lumbar and neck of femur research groups, including the case group and the control group, were compared. The contents of osteocalcin calcium and phosphorus in serum were also measured and evaluated. The results showed that the mean bone mineral density of the case group (TMJOA group) was lower than that of the control group (healthy control). However, a statistical difference was not reflected. The mineral density of the neck of femur of the case group is lower than that of the controlled group obviously, suggesting that mineral density of the femur was related with TMJOA. It was presumed that the bone mineral density of the femur neck might have relationship with TMJOA. The level of osteocalcin in serum of the case group was significantly lower than that of the control group. Thus it is presumed that osteocalcin had a relationship with TMJOA. The results showed that the capability of bone transformation and formation in TMJOA were all decreased. No relationship was found between calcium phosphorus in serum and TMJOA.

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Effect of estrogen on bone resorption and inflammation in the temporomandibular joint cellular elements

Cited by 15 publications

References 26 publications

Estrogen stimulates leptin receptor expression in ATDC5 cells via the estrogen receptor and extracellular signal-regulated kinase pathways

Estrogen stimulates leptin receptor expression in ATDC5 cells via the estrogen receptor and extracellular signal-regulated kinase pathways

Pathophysiology and Pharmacologic Control of Osseous Mandibular Condylar Resorption

Investigation of Characteristic Indeices Related to Temporomandibular Joint Osteoarthrosis

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