Effect of Ethanolic Rind Extract of Citrullus lanatus on the Hpg Axis and Sexual Behavior of Male Wistar Rats

Atuadu, Vivian

doi:10.18782/2320-7051.6256

Cited by 5 publications

(3 citation statements)

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“…This was also reported f or CL seed (Khaki et al, 2014). The hypophyseal axis and sexual behavior of male Wistar rats are upregulated by the ethanolic extract of CL rind (Atuadu et al, 2018). Kolawole et al, (2014) also reported that CL rind improves semen parameters, reproductive hormones, and testicular oxidative status.…”

Section: Reproductionmentioning

confidence: 98%

“…The ethanolic watermelon seed extract has been shown to have signif icant immunoreactivity to neurof ilament protein antibody to improve cognitive f unctions (Finbarrs et al, 2018;Owoeye et al, 2018). Incorporating watermelon rind in f lour f or cake production has enhanced nutritional quality, chemical and f unctional properties (Imoisi et al, 2020).…”

Section: Neuroprotectivementioning

confidence: 99%

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Review of studies published on the medicinal importance of different parts of Citrullus lanatus in the last ten years

Akintunde¹,

Thomas²

2022

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Watermelon (Citrullus lanatus), (CL) is an edible fruit of Cucurbitaceae family. It is cultivated worldwide for it is nutritive and medicinal values. The records of online scientific publications on CL were accessed using Google, Google Scholar, PubMed, science.gov, Scopus, and Worldwide science as search engines, were collected from January 2010 to April 2021 and analyzed using descriptive statis tics. Emphasis was placed on phytochemical, proximate, antioxidant, and pharmacological published articles on different parts of CL during this period. A total of 121 published articles that focused on different parts of CL in the last ten years were retrieved with phytochemicals 17.4% (21), proximate 7.4% (9), antioxidants 6.6% (8), pharmacology 68.6% (83). The pharmacology field was subdivided into antimicrobial 14.9% (18), cardioprotective 10.2% (13), reproduction 9.2% (12), toxicology and hepatoprotective 6.6% (8) each, analgesic, and anti-inflammatory 5.8%, neuroprotective 3.3% (4), anthelmintics (0.8%). Considering publications on different parts of CL, the seed received the highest attention with 42.1% (51) followed by fruits 35.5% (43), rind 18.1% (22), leaf 2.5% (3) while the least was whole fruit 1.7% (2). It was observed in this review on published articles that the CL fruits received the highest level of attention considering the phytochemicals, proximate, and antioxidant components to exhibit good antimicrobial potentials. While the CL leaf receivedlittle attention on antimicrobial ability. Also, different parts exhibited cardioprotective, reproduction, toxicology, hepatoprotective, neuroprotective, analgesic, and anti-inflammatory activities, anti-ulcerative efficacy due to phytochemicals, antioxidant, and proximate constituents in different parts of CL. It is worth noting that neuroprotective, hepatoprotective, antidiabetic, and anthelmintics effects of different parts of CL received little attention. While there is still dearth of information on use of different parts of CL on cancer investigations and use. This scientific review on different parts of CL had highlighted knowledge gap that still exists on different parts of CL.

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Section: Reproductionmentioning

confidence: 98%

Section: Neuroprotectivementioning

confidence: 99%

Review of studies published on the medicinal importance of different parts of Citrullus lanatus in the last ten years

Akintunde¹,

Thomas²

2022

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“…The increased blood flow causes engorgement of the vaginal wall which causes an increase in pressure that forces plasma out of the subepithelial vascular bed through the vaginal epithelium via intraepithelial spaces into the vaginal canal [8] , thereby causing vaginal wetness. Although several studies have established the aphrodisiac effect of Citrullus lanatus flesh, seed and rind extracts on adult male wistar rats [9][10][11] and sex enhancing propensity of Citrullus lanatus seed extract on female Wistar rats [12] , there is lack of documented scientific literature on the sex enhancing property of the rind extract Citrullus lanatus on sexual behaviors of adult female Wistar rat.…”

Section: Introductionmentioning

confidence: 99%

Effect of ethanolic rind extract of Citrullus lanatus on hypothalamic-pituitary-gonadal axis structures, sexual behaviour and hormones of female Wistar rats

Anyanwu¹,

Atuadu²,

Egwuatu³

et al. 2021

J Pharmacogn Phytochem

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Background: Female sexual disorder is rarely considered, even thou females experience sexual dysfunction more than males. Aim: Hence, this work was aimed at evaluating the effect of Citrullus lanatus ethanolic rind extract (CERE) on structures of hypothalamic-pituitary-gonadal (HPG) axis, hormones and sexual behaviour of adult female Wistar rats. Methods: Female Wistar rats of 10 weeks' old were randomized into 4 groups (n=7). Groups I-III received oral saline (1 mL/kg), CERE (500 and 1000 mg/kg) daily for 14 days. Group VI received weekly hormonal treatment. Thereafter sexual behavioural test with sexually experienced male rats in unilevel pacing chamber was conducted. Female sexual behavioural parameters were scored. Blood was collected for hormonal assay. The animals were euthanized, thereafter ovaries, uterus, and hypothalamus were harvested for histological examination. Results: CERE enhanced libido by increasing significantly (P<0.05) solicitation, hops and darts, time spent in the male compartment with corresponding decrease in the time spent in the female compartment relative to control group. Hormonal assay revealed significant increase in serum Luteinizing and Follicle Stimulating Hormone levels of CERE treated rats. Histological findings showed improved histoarchitecture of the uterine, ovarian and hypothalamic sections. Conclusion: CERE has aphrodisiac properties, therefore may be used for the treatment of women with hypoactive sexual desire.

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Citrullus Lanatus (Watermelon) Wastes: Maximizing the Benefits and Saving the Environment

Elsayed

Yousof

Khalil

et al. 2022

Mediterranean Fruits Bio-Wastes

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Effect of Ethanolic Rind Extract of Citrullus lanatus on the Hpg Axis and Sexual Behavior of Male Wistar Rats

Cited by 5 publications

References 0 publications

Review of studies published on the medicinal importance of different parts of Citrullus lanatus in the last ten years

Review of studies published on the medicinal importance of different parts of Citrullus lanatus in the last ten years

Effect of ethanolic rind extract of Citrullus lanatus on hypothalamic-pituitary-gonadal axis structures, sexual behaviour and hormones of female Wistar rats

Citrullus Lanatus (Watermelon) Wastes: Maximizing the Benefits and Saving the Environment

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