Effect of exercise on fluoride metabolism in adult humans: a pilot study

Zohoori, Fatemeh; Innerd, Alison; Azevedo, Liane B.; Whitford, Gary M.; Maguire, Anne

doi:10.1038/srep16905

Cited by 20 publications

(16 citation statements)

References 33 publications

(50 reference statements)

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“…Physical activity/sedentary behaviour and/or skeletal development stage impacts DUFE, with renal clearance of F declining with increasing physical activity . A recent study in South Africa, reported an increase in activity level with age; with 9‐11 year‐old boys and 12‐14 year‐old girls more physically and aerobically active than boys and girls aged 5‐6 years .…”

Section: Discussionmentioning

confidence: 99%

Fluoride intake and urinary fluoride excretion in 4‐ and 8‐year‐old children living in urban and rural areas of Southwest Nigeria

Ibiyemi

Zohoori

Valentine

et al. 2018

Comm Dent Oral Epid

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Fluoride intake in these 4- and 8-year-old Nigerians was much higher than the "optimal range" of 0.05-0.07 mg/kg bw/d in rural, higher F water areas, with diet as the main contributor. F retention was similar in both age groups, with almost half of TDFI retained in the body. In terms of risk vs benefit for fluorosis and dental caries, this finding should be considered when mitigating against excessive fluoride exposure and planning F-based prevention.

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Section: Discussionmentioning

confidence: 99%

Fluoride intake and urinary fluoride excretion in 4‐ and 8‐year‐old children living in urban and rural areas of Southwest Nigeria

Ibiyemi

Zohoori

Valentine

et al. 2018

Comm Dent Oral Epid

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“…Recently, Zohoori et al (2015) measured fasting ionic F levels in nine healthy adults aged 20–35 years (5 men and 4 women) residing in a nonfluoridated community in the UK [218]. The mean baseline ionic plasma F level was reported to be 3.2 μ mol/l.…”

Section: Discussionmentioning

confidence: 99%

Black Tea Source, Production, and Consumption: Assessment of Health Risks of Fluoride Intake in New Zealand

Waugh¹,

Godfrey

Limeback

et al. 2017

Journal of Environmental and Public Health

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In countries with fluoridation of public water, it is imperative to determine other dietary sources of fluoride intake to reduce the public health risk of chronic exposure. New Zealand has one of the highest per capita consumption rates of black tea internationally and is one of the few countries to artificially fluoridate public water; yet no information is available to consumers on the fluoride levels in tea products. In this study, we determined the contribution of black tea as a source of dietary fluoride intake by measuring the fluoride content in 18 brands of commercially available products in New Zealand. Fluoride concentrations were measured by potentiometric method with a fluoride ion-selective electrode and the contribution of black tea to Adequate Intake (AI) and Tolerable Upper Intake Level (UL) was calculated for a range of consumption scenarios. We examined factors that influence the fluoride content in manufactured tea and tea infusions, as well as temporal changes in fluoride exposure from black tea. We review the international evidence regarding chronic fluoride intake and its association with chronic pain, arthritic disease, and musculoskeletal disorders and provide insights into possible association between fluoride intake and the high prevalence of these disorders in New Zealand.

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“…It was observed in our previous studies, which were performed on a similar experimental model, that long-term fluoride exposure of rats did not produce any changes in the fluoride concentration in the serum, probably because of high urinary removal [19]; however, accumulation of this element was observed in some brain structures [20]. Thus, fluoride may act as a neurotoxic agent despite its low level in serum.…”

Section: Discussionmentioning

confidence: 67%

Fluoride Affects Dopamine Metabolism and Causes Changes in the Expression of Dopamine Receptors (D1R and D2R) in Chosen Brain Structures of Morphine-Dependent Rats

Kupnicka

Listos

Tarnowski

et al. 2020

IJMS

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Disturbances caused by excess or shortages of certain elements can affect the cerebral reward system and may therefore modulate the processes associated with the development of dependence as was confirmed by behavioural studies on animals addicted to morphine. Earlier publications demonstrated and proved the neurodegenerative properties of both low and high doses of fluoride ions in animal experiments and in epidemiological and clinical studies. The aim of the experiments conducted in the course of the present study was to analyse the effect of pre- and postnatal exposure to 50 ppm F− on the initiation/development of morphine dependence. For this purpose, the following were conducted: behavioural studies, the analysis of concentrations of dopamine and its metabolites, and the analyses of mRNA expression and dopamine receptor proteins D1 and D2 in the prefrontal cortex, striatum, hippocampus, and cerebellum of rats. In this study, it was observed for the first time that pre- and postnatal exposure to fluoride ions influenced the phenomenon of morphine dependence in a model expressing withdrawal symptoms. Behavioural, molecular, and neurochemical studies demonstrated that the degenerative changes caused by toxic activity of fluoride ions during the developmental period of the nervous system may impair the functioning of the dopaminergic pathway due to changes in dopamine concentration and in dopamine receptors. Moreover, the dopaminergic disturbances within the striatum and the cerebellum played a predominant role as both alterations of dopamine metabolism and profound alterations in striatal D1 and D2 receptors were discovered in these structures. The present study provides a new insight into a global problem showing direct associations between environmental factors and addictive disorders.

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Effect of exercise on fluoride metabolism in adult humans: a pilot study

Cited by 20 publications

References 33 publications

Fluoride intake and urinary fluoride excretion in 4‐ and 8‐year‐old children living in urban and rural areas of Southwest Nigeria

Fluoride intake and urinary fluoride excretion in 4‐ and 8‐year‐old children living in urban and rural areas of Southwest Nigeria

Black Tea Source, Production, and Consumption: Assessment of Health Risks of Fluoride Intake in New Zealand

Fluoride Affects Dopamine Metabolism and Causes Changes in the Expression of Dopamine Receptors (D1R and D2R) in Chosen Brain Structures of Morphine-Dependent Rats

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