Effect of exergaming versus combined exercise on cognitive function and brain activation in frail older adults: A randomised controlled trial

Liao, Ying-Yi; Chen, I‐Hsuan; Hsu, Wei‐Chun; Tseng, Han-Yun; Wang, Ray-Yau

doi:10.1016/j.rehab.2021.101492

Cited by 59 publications

(72 citation statements)

References 38 publications

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“…Frontal and subcortical-frontal cortex volumes are associated with single and dual-task gait performance in older adults with MCI ( Doi et al, 2017 ; Allali et al, 2019 ; Beauchet et al, 2019 ). Previous studies have shown evidence that VR and exergaming improve brain activation ( Liao et al, 2020 , 2021 ). Although we did not measure brain function, we suggest that EXER-TC improved brain plasticity in older adults with MCI.…”

Section: Discussionmentioning

confidence: 99%

Effects of Exergaming-Based Tai Chi on Cognitive Function and Dual-Task Gait Performance in Older Adults With Mild Cognitive Impairment: A Randomized Control Trial

Liu

Cheng

Wei

et al. 2022

Front. Aging Neurosci.

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BackgroundDeclined cognitive function interferes with dual-task walking ability and may result in falls in older adults with mild cognitive impairment (MCI). The mind-body exercise, Tai Chi (TC), improves cognition and dual-task ability. Exergaming is low-cost, safe, highly scalable, and feasible. Whether the effects of exergaming-based TC is beneficial than traditional TC has not been investigated yet.ObjectivesThe objective of this study was to investigate effects of exergaming-based TC on cognitive function and dual-task walking among older adults with MCI.MethodsFifty patients with MCI were randomly assigned to an exergaming-based TC (EXER-TC) group, a traditional TC (TC) group, or a control group. The EXER-TC and TC groups received 36 training sessions (three, 50-min sessions per week) during a 12-week period. The control group received no intervention and were instructed to maintain their usual daily physical activities. The outcome variables measured included those related to cognitive function, dual-task cost (DTC), and gait performance.ResultsThe EXER-TC and TC groups performed better than the control group on the Chinese version of the Stroop Color and Word Test, the Trail Making Test Parts A and B, the one-back test, gait speed, and DTC of gait speed in cognitive dual-task conditions after training. However, there were no significant differences between the EXER-TC and TC groups. Compared with the control group, only the EXER-TC group experienced beneficial effects for the Montreal Cognitive Assessment.ConclusionEXER-TC was comparable to traditional TC for enhancement of dual-task gait performance and executive function. These results suggested that the EXER-TC approach has potential therapeutic use in older adults with MCI.

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Section: Discussionmentioning

confidence: 99%

Effects of Exergaming-Based Tai Chi on Cognitive Function and Dual-Task Gait Performance in Older Adults With Mild Cognitive Impairment: A Randomized Control Trial

Liu

Cheng

Wei

et al. 2022

Front. Aging Neurosci.

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“…The effect of serious games was compared with conventional exercises in 6 studies [ 35 - 40 ]. While 3 studies did not find a statistically significant difference in global cognition between the groups [ 35 - 37 ], the 3 remaining studies showed a statistically significant difference in global cognition between the groups, favoring serious games over conventional exercises [ 38 - 40 ].…”

Section: Resultsmentioning

confidence: 99%

“…Five studies assessed the safety of serious games by checking adverse events [ 34 - 38 ]. Of these, 2 studies did not find any adverse events of the interventions during the study period [ 37 , 38 ]. The 3 remaining studies spotted some adverse events, but they were comparable between groups [ 34 - 36 ].…”

Section: Resultsmentioning

confidence: 99%

The Effectiveness and Safety of Serious Games for Improving Cognitive Abilities Among Elderly People With Cognitive Impairment: Systematic Review and Meta-Analysis

Abd‐Alrazaq¹,

Alajlani²,

Alhuwail³

et al. 2022

JMIR Serious Games

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Background Cognitive impairment is a mental disorder that commonly affects elderly people. Serious games, which are games that have a purpose other than entertainment, have been used as a nonpharmacological intervention for improving cognitive abilities. The effectiveness and safety of serious games for improving cognitive abilities have been investigated by several systematic reviews; however, they are limited by design and methodological weaknesses. Objective This study aims to assess the effectiveness and safety of serious games for improving cognitive abilities among elderly people with cognitive impairment. Methods A systematic review of randomized controlled trials (RCTs) was conducted. The following 8 electronic databases were searched: MEDLINE, Embase, CINAHL, PsycINFO, ACM Digital Library, IEEE Xplore, Scopus, and Google Scholar. We also screened reference lists of the included studies and relevant reviews, as well as checked studies citing our included studies. Two reviewers independently carried out the study selection, data extraction, risk of bias assessment, and quality of evidence appraisal. We used a narrative and statistical approach, as appropriate, to synthesize the results of the included studies. Results Fifteen studies met the eligibility criteria among 466 citations retrieved. Of those, 14 RCTs were eventually included in the meta-analysis. We found that, regardless of their type, serious games were more effective than no intervention (P=.04) and conventional exercises (P=.002) for improving global cognition among elderly people with cognitive impairment. Further, a subgroup analysis showed that cognitive training games were more effective than no intervention (P=.05) and conventional exercises (P<.001) for improving global cognition among elderly people with cognitive impairment. Another subgroup analysis demonstrated that exergames (a category of serious games that includes physical exercises) are as effective as no intervention and conventional exercises (P=.38) for improving global cognition among elderly people with cognitive impairment. Although some studies found adverse events from using serious games, the number of adverse events (ie, falls and exacerbations of pre-existing arthritis symptoms) was comparable between the serious game and control groups. Conclusions Serious games and specifically cognitive training games have the potential to improve global cognition among elderly people with cognitive impairment. However, our findings remain inconclusive because the quality of evidence in all meta-analyses was very low, mainly due to the risk of bias raised in the majority of the included studies, high heterogeneity of the evidence, and imprecision of total effect sizes. Therefore, psychologists, psychiatrists, and patients should consider offering serious games as a complement and not a substitute to existing interventions until further more robust evidence is available. Further studies are needed to assess the effect of exergames, the safety of serious games, and their long-term effects.

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“…During the COVID-19 pandemic, central-based or home-based face-to-face supervision has been forced to stop, and we need an alternative delivery mode ( García Pérez de Sevilla et al, 2021 ). Remote assessment and guidance become the most feasible way ( Liao et al, 2021 ). Although compared with traditional training, there is no significant difference in remote supervision, but it reached the same benefits at least ( Geraedts et al, 2021 ; Gagnon et al, 2022 ).…”

Section: Discussionmentioning

confidence: 99%

Effects of Remotely Supervised Physical Activity on Health Profile in Frail Older Adults: A Randomized Controlled Trial Protocol

Zhang

Sui

et al. 2022

Front. Aging Neurosci.

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BackgroundFrailty is considered a major public health challenge of the 21st century, characterized by the decline of multiform body functions. Physical activity may be the most effective intervention to delay frailty. This study aims to verify the effect of remotely supervised physical activity on health profile in community-dwelling frail older adults.DesignThis is a multicenter, three-blind, two-arm, and cohort randomized controlled study.MethodsThe intelligent exercise rehabilitation management system (IERMS) is an integrated digital platform that involves evaluation, guidance, monitoring, and feedback. A total of 120 participants aged ≥ 65 years and diagnosed as frailty on the FRAIL scale will be recruited and randomly divided into two groups. Group 1 will receive a 12-week IERMS-based intervention, and Group 2 will receive the usual care. Data will be collected at baseline, 12 and 24 weeks. The primary outcome is the physical function, and secondary outcomes include gait parameters, psychology, and cognition measurements. Analyses will be performed using DSS statistics, version 25. P < 0.05 will be considered statistically significant.ConclusionWe believe that intervention plays a positive role in delaying the frailty. If our program is effective, we will provide a viable means to promote healthy aging in primary healthcare.Trial registration numberChiCTR2100052286; Pre-results.

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Effect of exergaming versus combined exercise on cognitive function and brain activation in frail older adults: A randomised controlled trial

Cited by 59 publications

References 38 publications

Effects of Exergaming-Based Tai Chi on Cognitive Function and Dual-Task Gait Performance in Older Adults With Mild Cognitive Impairment: A Randomized Control Trial

Effects of Exergaming-Based Tai Chi on Cognitive Function and Dual-Task Gait Performance in Older Adults With Mild Cognitive Impairment: A Randomized Control Trial

The Effectiveness and Safety of Serious Games for Improving Cognitive Abilities Among Elderly People With Cognitive Impairment: Systematic Review and Meta-Analysis

Effects of Remotely Supervised Physical Activity on Health Profile in Frail Older Adults: A Randomized Controlled Trial Protocol

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