Effect of extracts and isolated compounds from Chresta scapigera on viability of Leishmania amazonensis and Trypanosoma cruzi

Abstract

Fractionation of bioactive crude extracts of Chresta scapigera led to the isolation of four triterpenes and five flavonoids, among them β-amyrin acetate (1), 11α,12α-oxidetaraxeryl acetate (2) and lupeol (3), as well as the flavonoids apigenin (6), kaempferol (7), crysoeriol (8) and luteolin (9) were active against Leishmania amazonensis amastigotes-like stages, while only the flavonoids (6), (7) and (9) showed toxicity towards bloods trypomastigote forms of Trypanosoma cruzi.

Anti-promastigote Activity of the Amazon Plants

“…Another study evaluated the anti-amastigote activity in L. amazonensis of lupeol, being observed significant inhibitory activity in 500 µg/mL [20]. These results suggest that lupeol and plants rich in lupeol are not promising as anti-leishmanial.…”

Avaliação da atividade antileishmania in vitro de Tanacetum vulgare (Asteraceae)

“…A família Asteraceae está sendo investigada por muitos laboratórios e apresenta importantes perspectivas para o desenvolvimento de medicamentos contra diferentes agentes parasitários, como, Leishmania amazonensis e Trypanosoma cruzi (Schinor et al, 2007), Leishmania donovani e Plasmodium falciparum (Silva-Filho, et al, 2009) e Schistosoma mansoni (Almeida et al, 2016).…”

Antiproliferative activity, antioxidant capacity and chemical composition of extracts from the leaves and stem of Chresta sphaerocephala

“…Few species of the Chresta genus have been studied regarding its chemical composition and pharmacological potential. C. exsucca and C. scapigera presented significant potential regarding antimicrobial activity against bacteria, fungi and protozoa and steroids, terpenoids and flavonoids were identified on their bioactive extracts (Schinor et al, 2006(Schinor et al, , 2007a. These results indicate that species of this genus can be sources of active compounds.…”

“…The genus Chresta, comprises 12 endemic species in central Brazil, and some species showed antibacterial and antiprotozoal activites (Schinor et al, 2006(Schinor et al, , 2007aRobinson, 1999). These species are recognized by the population of northeastern Brazil as traditional herbs used to treat gastric diseases and other disorders, hence presenting ethnopharmacological relevance (Silva et al, 2012).…”