Effect of face mask dead volume, respiratory rate, and tidal volume on inhaled albuterol delivery

Abstract

In general, decreasing SDV, increasing VT, and increasing RR increase ACMO. Early transition from face mask to mouthpiece should be considered in children receiving albuterol via MDI with HC.

Effect of Mask Dead Space and Occlusion of Mask Holes on Delivery of Nebulized Albuterol

“…A previous study demonstrated that a larger dead space of the mask results in less albuterol delivered by pressurized metereddose inhaler (pMDI) to the mouth opening. 10 Therefore, masks designed to be used with pMDIs should ideally have a low dead space. However, no data are available regarding the effect of face mask dead space and nebulized drug delivery.…”

Computerized Dead-Space Volume Measurement of Face Masks Applied to Simulated Faces

“…1,8 This technique has limited value, as it usually requires that the mask be placed against a smooth, flat surface. However, children's faces are far from flat, and moreover, they develop and grow continuously and relatively rapidly.…”

“…Chavez et al 1 studied albuterol delivery via an AeroChamber and showed that greater dead space of a mask attached to this chamber resulted in less efficient aerosol delivery for the same V T . 1 Thus, the V D of a face mask is a very important determinant of face-mask design, 3 particularly in infants and small children with low V T . The mean V T in infants 9 months old was recently documented as 81.5 Ϯ 28.2 mL, with a mean V T of 9.7 Ϯ 1.3 mL/kg.…”

“…The dead-space volume (V D ) of a face mask has been shown to critically affect aerosol delivery to infants and young children. 1,2 Traditionally, data about V D have been obtained from water displacement measurements when masks are held against a flat surface, 1,3 with the inlet and outlet valves occluded. Because, in real life, masks are placed against the face, this functional V D is not obtained using the water displacement technique, which measures only the total volume of the mask and not V D …”

Salbutamol in asthma treatment: with nebulizer or inhaler?

“…Yüz maskesi uygun bir şekilde yüze oturtulmalı, yüzle temas ettiği bölgede hava kaçışı engellenmelidir. Ölü boşluğu azaltmak için mümkün olan en kısa sürede ağızlıklı kullanıma geçil-melidir (14).…”