Effect of feed frame on lubricant sensitivity during upscaling from a compaction simulator to a rotary tablet press

Impact of alternative lubricants on process and tablet quality for direct compression

“…For lactose and mannitol, the SpecWComp values were similar although lactose was slightly more susceptible to lubricant addition than mannitol. The lower lubricant sensitivity of mannitol is in agreement with previous research (de Backere et al, 2022;Tarlier et al, 2015) and can probably be attributed to its higher SSA (1.09 m 2 /g) compared to lactose (0.13 m 2 /g). The relative area covered by lubricant is smaller for a material with a larger SSA resulting in sufficient lubricant-free surface area available for bonding (Almaya and Aburub, 2008).…”

“…The effect of SA and MgSt on tensile strength, respectively, on lactose and MCC formulations agree with previous studies (de Backere et al, 2022;Paul and Sun, 2018). This can be attributed to the spherical shape of SA which is a less favorable shape towards covering filler particles, hence affecting the tensile strength to a lesser extent.…”

“…Nevertheless, several negative effects (i.e., reduced tabletability, longer disintegration and dissolution times) can be associated with internal lubrication, especially for MgSt (Desai et al, 1993;Jarosz and Parrot, 1984;Zuurman et al, 1999). These effects are further enhanced by high lubricant concentration, long blending time, intensive blending and high paddle speed (PS) of the tablet press feed frame (Bolhuis et al, 1981;de Backere et al, 2022;Dun et al, 2020a;Lerk et al, 1982;Paul and Sun, 2018;Peeters et al, 2016). Furthermore, the tensile strength of ductile materials is highly susceptible to the effect of internal lubrication as the lubricant-coated surfaces of ductile materials interferes with particle bonding.…”

“…The use of alternative lubricants like sodium stearyl fumarate (SSF) (de Backere et al, 2022;Hölzer and Sjögren, 1979;Kapadia and Deshmukh, 2017;Paul and Sun, 2018;Shah et al, 1986), stearic acid (SA) (de Backere et al, 2022;Paul and Sun, 2018;Ugurlu and Halaçoglu, 2014), poloxamers (Desai et al, 2007;Dun et al, 2020b), sodium lauryl sulfate (SLS) (Dun et al, 2018;Perrault et al, 2011), glyceryl dibehenate (DBHG) (N'Diaye et al, 2003;Shah et al, 1986;Ugurlu and Halaçoglu, 2014), polyethylene glycol (Dinesh and Mutahar, 2009;Kapadia and Deshmukh, 2017;Ugurlu and Halaçoglu, 2014) and sucrose fatty acid esters (Aoshima et al, 2005;Nakamura et al, 2017) for internal lubrication has been investigated by several authors.…”