Effect of fermented camel milk on glucose metabolism, insulin resistance, and inflammatory biomarkers of adolescents with metabolic syndrome: A double-blind, randomized, crossover trial

Abstract

Background:This study, for the first time, aimed to assess the effects of fermented camel milk (FCM) on glycemic and inflammatory parameters related to metabolic syndrome (MetS), an aggregation of cardiometabolic risk factors, in adolescents.Materials and Methods:In a double-blind, randomized crossover trial, overweight/obese adolescents (fulfilling MetS criteria, aged 11–18 years) were randomly assigned to receive FCM 250 cc per day for an 8-week period, a 4-week washout, and then diluted cow's yogurt (DCY) 250 cc/day for another 8-week period, or the reverse sequence. Fasting blood sugar (FBS), fasting insulin, insulin resistance by three equations, incretin hormone glucose-dependent insulinotropic peptide (GIP), and glucagon-like peptide-1 (GLP1) as well as inflammatory markers such as interleukin 6 (IL6) and tumor necrosis factor-alpha (TNF-α) were measured before and after each of the four periods. A 3-day food record and physical activity questionnaire were completed before each period. Statistical analyses were done using Minitab and SPSS software considering the significance level of 0.05.Results:Twenty-four participants with a mean (standard deviation) age of 13.77 (1.87) years (range: 10.45–16.25 years) (58% girls) completed the study. It resulted in nonsignificant mean reduction in IL6 (−18.28 pg/mL [95% confidence interval [CI]: −47.48; 10.90]; P = 0.20) and nonsignificant increase in glucose metabolizing hormones such as GIP (683.10 pg/mL [95% CI: −457.84; 1824.0]; P = 0.22) and GLP1 (6.98 pg/mL [95% CI: −66.61; 80.57]; P = 0.84) by FCM consumption in comparison to DCY. Nonsignificant decrease was observed in TNF-α in the first periods of the study. The changes of FBS, fasting insulin, and insulin resistance indices were not statistically significant as well.Conclusion:According to preliminary positive influences of FCM on inflammatory markers, and findings related to glucose metabolism, we suggest conducting further studies on its clinical impacts.

Effect of Fermented Camel Milk on Obesity Measures and Blood Pressure of Adolescents With Metabolic Syndrome

“…The study participants were consecutively recruited from March 2016 to December 2016 through screening the overweight or obese adolescents referring to the affiliated clinic of Child and Growth Development Research Center (in Amin Hospital, IUMS), and the private practice offices of the study's principal investigators. More details about the methods and procedures of the main study have been presented elsewhere (18,19).…”

“…Lactobacilli were used in the production of FCM as well. Dietary constituents of them are presented elsewhere (18)(19).…”

“…Mean of two measures was used in the statistical analysis. Immediately before and after each period, the subjects were referred to take some fasting laboratory tests which their results are reported elsewhere (18,19). A standard three-day food record was completed one week prior to each period.…”

Antioxidant and anticancer activities of Lactobacillus Hilgardii strain AG12a

“…Camel doogh is the homemade fermented camel milk made by Turkmens in Iran. [ 12 ] Our previous study showed that most of the Lactobacillus species isolated from camel dough have the potential of antimicrobial and antioxidant activities. [ 13 ] The aim of the present study is to investigate the anticancer activity of these Lactobacillus strains and separate a bioactive fraction from their extracellular methanol extracts by thin layer chromatography (TLC) and evaluate the apoptotic effect of the fraction against cancer cell lines.…”

Camel milk for reduction of diabetes risk: Are we heading toward the right direction?

“…Therapeutic potential of camel milk is being proclaimed by numerous reports with diabetes treatment being one of popularly studied aspect. [234] We herewith aim to critically evaluate current evidences assessing the use of camel milk for the reduction of diabetes risk and if so which type of diabetes.…”