Effect of Fermented Fish Oil on Fine Particulate Matter-Induced Skin Aging

Hyun, Yu Jae; Piao, Mei Jing; Kang, Kyoung Ah; Zhen, Ao Xuan; Fernando, Pincha Devage Sameera Madushan; Kang, Hee Kyoung; Ahn, Yong Seok; Hyun, Jin Won

doi:10.3390/md17010061

Cited by 37 publications

(45 citation statements)

References 30 publications

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“…In the present study, we proved that PM could induce MMP-2 and MMP-9 activity and expression in SCC4 and SCC25 cells. On the other hand, PM2.5 has been shown to induce MMP-2 and MMP-9 expression in human keratinocytes and cause skin aging [6]. Indeed, we also found that the levels of MMP-2 and MMP-9 in oral cancer cells or breast cancer cells are higher than in human gingival fibroblasts under the stimulation of PM ( Supplementary Fig.…”

Section: Discussionsupporting

confidence: 59%

“…MMP-2 or MMP-9 has been shown to play an important role in regulating metastasis including oral cancer [5,7]. PM2.5 also has been shown to induce MMP-2 and MMP-9 expression in keratinocytes [6]. Therefore, reducing the expression of MMP-2 and MMP-9 or its upstream regulatory signaling pathways is essential for the treatment of malignant tumors.…”

Section: Ivyspringmentioning

confidence: 99%

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Surfactin from Bacillus subtilis attenuates ambient air particulate matter-promoted human oral cancer cells metastatic potential

Lee

et al. 2020

J. Cancer

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Recently, many studies have indicated that ambient air particulate matter (PM) can increase the risk of oral cancer. The most common malignant tumor in the oral cavity is oral squamous cell carcinoma (OSCC). Usually, cancer cell migration/invasion is the most important cause of cancer mortality. Matrix metalloproteinase-2 (MMP-2) and MMP-9 have been shown to play important roles in regulating metastasis and the tumor microenvironment. Here, we studied the anti-cancer effects of surfactin, a cyclic lipopeptide generated by Bacillus subtilis, on cancer cell migration and invasion. Surfactin suppressed PM-promoted cell migration and invasion and colony formation of SCC4 and SCC25 human oral squamous cell carcinoma cell lines. We observed that PM induced MMP-2 and MMP-9 expression, which was inhibited by surfactin. Transfection with p65, p50, c-Jun, c-Fos, p85, p110, Akt, mammalian target of rapamycin (mTOR), or interleukin-6 (IL-6) siRNA markedly inhibited PM-induced MMP-2 and MMP-9 expression. Moreover, surfactin could reduce Akt, mTOR, p65, and c-Jun activation and IL-6 secretion induced by PM. Finally, we proved that transfection with Akt, p65, or c-Jun siRNA significantly inhibited PM-induced IL-6 release. Taken together, these results suggest that surfactin functions as a suppressor of PM-induced MMP2/9-dependent oral cancer cell migration and invasion by inhibiting the activation of phosphoinositide 3-kinase (PI3K)/Akt/mTOR and PI3K/Akt/nuclear factor-κB (NF-κB) and activator protein-1 (AP-1)/IL-6 signaling pathways.

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Section: Discussionsupporting

confidence: 59%

Section: Ivyspringmentioning

confidence: 99%

Surfactin from Bacillus subtilis attenuates ambient air particulate matter-promoted human oral cancer cells metastatic potential

Lee

et al. 2020

J. Cancer

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“…The endoplasmic reticulum (ER) is responsible for most of the intracellular Ca 2+, and, as a result, changes in the cellular Ca 2+ -balance activate ER stress [196]. PM was shown to induce ER stress, as measured by increased levels of intracellular Ca 2+ [123,168,175,[184][185][186]. Additionally, the ER stress sensor proteins for unfolded or misfolded proteins, protein kinase-like ER kinase (PERK), inositol-requiring 1 alpha (IRE1α), and activating transcription factor 6 (ATF6) [197], were activated in vitro [123,175].…”

Section: Pm Triggers Exogenous and Endogenous Ros Formationmentioning

confidence: 99%

Impact of airborne particulate matter on skin: a systematic review from epidemiology to in vitro studies

Dijkhoff¹,

Drašler²,

Karakoçak³

et al. 2020

Part Fibre Toxicol

126

116

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Background: Air pollution is killing close to 5 million people a year, and harming billions more. Air pollution levels remain extremely high in many parts of the world, and air pollution-associated premature deaths have been reported for urbanized areas, particularly linked to the presence of airborne nano-sized and ultrafine particles. Main text: To date, most of the research studies did focus on the adverse effects of air pollution on the human cardiovascular and respiratory systems. Although the skin is in direct contact with air pollutants, their damaging effects on the skin are still under investigation. Epidemiological data suggested a correlation between exposure to air pollutants and aggravation of symptoms of chronic immunological skin diseases. In this study, a systematic literature review was conducted to understand the current knowledge on the effects of airborne particulate matter on human skin. It aims at providing a deeper understanding of the interactions between air pollutants and skin to further assess their potential risks for human health. Conclusion: Particulate matter was shown to induce a skin barrier dysfunction and provoke the formation of reactive oxygen species through direct and indirect mechanisms, leading to oxidative stress and induced activation of the inflammatory cascade in human skin. Moreover, a positive correlation was reported between extrinsic aging and atopic eczema relative risk with increasing particulate matter exposure.

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“…Skin serves as the protective barrier of the body and protects it from harmful agents, such as ultraviolet (UV) radiation, heat and microorganisms (1,2). damage to the skin tissue not only causes damage to the subcutaneous tissue, but also affects the internal balance of the body (3,4).…”

Section: Introductionmentioning

confidence: 99%

Spirulina protein promotes skin wound repair in a mouse model of full-thickness dermal excisional wound

et al. 2020

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The skin protects body from environmental damage. Skin wounds lead to microbial infection and harmful agent injury. Thus, wound repair is crucial for the recovery of the normal function of skin tissue. The present study investigated the promoting effects of spirulina protein (SPcP) in mice on skin wound repair and also aimed to elucidate the potential underlying mechanisms. The results revealed that SPcP promoted the skin wound repair in a mouse model of full-thickness excisional wounds. SPcP induced an increase in the expression level of α-smooth muscle actin (α-SMA). The activities of superoxide dismutase (SOd) and catalase (cAT) were enhanced by SPcP treatment in the granulation tissue. In addition, SPcP decreased the level of malondialdehyde (MdA) in the granulation tissue. Western blot analysis revealed that SPcP enhanced the phosphorylation and activation of protein kinase B (Akt) and extracellular signal-regulated kinase (ERK). Moreover, the expression level of transforming growth factor β1 (TGF-β1) was increased in the SPcP-treated groups. The phosphorylation level of Smad2 was also increased by treatment of SPcP. Furthermore, SPcP promoted the expression of collagen in the granulation tissue. Taken together, these findings indicate that SPCP exerts a promoting effect on skin wound repair. The Akt, ERK and TGF-β1 signaling pathways are involved in this process.

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Effect of Fermented Fish Oil on Fine Particulate Matter-Induced Skin Aging

Cited by 37 publications

References 30 publications

Surfactin from Bacillus subtilis attenuates ambient air particulate matter-promoted human oral cancer cells metastatic potential

Surfactin from Bacillus subtilis attenuates ambient air particulate matter-promoted human oral cancer cells metastatic potential

Impact of airborne particulate matter on skin: a systematic review from epidemiology to in vitro studies

Spirulina protein promotes skin wound repair in a mouse model of full-thickness dermal excisional wound

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