Effect of five Alive&amp;#174 fruit juice on the dissolution and absorption profiles of ciprofloxacin

Akinleye, M.O.; Coker, H. A. B.; Chukwuani, C M; Adeoye, A W

doi:10.4314/nqjhm.v17i1.12542

Cited by 9 publications

(5 citation statements)

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“…It was found that the absorption of ciprofloxacin (500 mg) tablets can be reduced by concomitant ingestion of the GFJ. 48 Therefore, to avoid drug therapeutic failures and subsequent bacterial resistance as a result of sub-therapeutic level of the drug in the systemic circulation, ingestion of the juice with ciprofloxacin should be discouraged. 48 Azithromycin absorption is decreased when taken with food, resulting in a 43% reduction in bioavailability.…”

Section: Antibioticsmentioning

confidence: 99%

“…48 Therefore, to avoid drug therapeutic failures and subsequent bacterial resistance as a result of sub-therapeutic level of the drug in the systemic circulation, ingestion of the juice with ciprofloxacin should be discouraged. 48 Azithromycin absorption is decreased when taken with food, resulting in a 43% reduction in bioavailability. 39 Tetracycline should be taken one hour before or two hours after meals, and not taken with milk because it binds calcium and iron, forming insoluble chelates, and influencing its bioavailability.…”

Section: Antibioticsmentioning

confidence: 99%

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Food Drug Interactions

Bushra¹,

Aslam²,

Khan³

2011

OMJ

225

147

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The effect of drug on a person may be different than expected because that drug interacts with another drug the person is taking (drug-drug interaction), food, beverages, dietary supplements the person is consuming (drug-nutrient/food interaction) or another disease the person has (drug-disease interaction). A drug interaction is a situation in which a substance affects the activity of a drug, i.e. the effects are increased or decreased, or they produce a new effect that neither produces on its own. These interactions may occur out of accidental misuse or due to lack of knowledge about the active ingredients involved in the relevant substances. Regarding food-drug interactions physicians and pharmacists recognize that some foods and drugs, when taken simultaneously, can alter the body's ability to utilize a particular food or drug, or cause serious side effects. Clinically significant drug interactions, which pose potential harm to the patient, may result from changes in pharmaceutical, pharmacokinetic, or pharmacodynamic properties. Some may be taken advantage of, to the benefit of patients, but more commonly drug interactions result in adverse drug events. Therefore it is advisable for patients to follow the physician and doctors instructions to obtain maximum benefits with least food-drug interactions. The literature survey was conducted by extracting data from different review and original articles on general or specific drug interactions with food. This review gives information about various interactions between different foods and drugs and will help physicians and pharmacists prescribe drugs cautiously with only suitable food supplement to get maximum benefit for the patient.

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Section: Antibioticsmentioning

confidence: 99%

Section: Antibioticsmentioning

confidence: 99%

Food Drug Interactions

Bushra¹,

Aslam²,

Khan³

2011

OMJ

225

147

View full text Add to dashboard Cite

show abstract

“…But in the clinic, as well as in everyday life, other beverages can also be used to aid the swallowing of the medicament, such as fruit juices and, in more extreme cases, alcoholic beverages. While metabolic interactions with fruit juice are well known (An et al, 2015;Bailey et al, 1998), the interaction between dosage forms and other type of beverages is still limited and mainly focused on tablets disintegration (Akinleye et al, 2007;Anwar et al, 2005;Chuong et al, 2010;Kalantzi et al, 2005;Wells and Losin, 2008;Zuo et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

An in vitro–in vivo correlation study for nifedipine immediate release capsules administered with water, alcoholic and non-alcoholic beverages: Impact of in vitro dissolution media and hydrodynamics

Mercuri

Fares

Bresciani

et al. 2016

International Journal of Pharmaceutics

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The impact of hydrodynamics and media composition on nifedipine dissolution profile from IR (immediate release) soft capsules was investigated using dissolution apparatus USP1, USP2, USP3 and USP4 (United State Pharmacopoeia). Media composition was varied in terms of pH and content, to mimic the dosage form intake with water or non-alcoholic beverages (orange juice) and alcoholic beverages (orange juice/ethanol mixture (47% v/v)). Through construction of in vitro-in vivo correlations (IVIVC) with corresponding in vivo data from the literature, it was possible to evaluate the in vitro conditions that are likely to simulate the in vivo formulation behaviour. Both linear and nonlinear correlations were obtained depending on experimental set-ups. Testing of 20mg nifedipine capsules in FaSSGFst (Fasted State Simulated Gastric Fluid pH 1.6; water administration) produced IVIVC with the USP3 (after time scaling) and USP4 apparatus. IVIVC were obtained for USP2, USP3 and USP4 in FaSSGFoj (Fasted State Simulated Gastric Fluid pH 3.4; orange juice administration). Linear and nonlinear correlations were obtained with the USP1, USP2 and USP3 apparatus when testing the capsules in FaSSGFoj/EtOH (orange juice/ethanol administration). This study highlighted that selection of physiologically relevant dissolution set-ups is critical for predicting the in vivo impact of formulations co-administration with water, non-alcoholic and alcoholic beverages.

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“…The absorption of ciprofloxacin is decreased if it is taken with milk due to the presence of casein and calcium [26]. Akinleye et al reported that the effect of interaction of some fruit juices on the absorption and dissolution profiles of ciprofloxacin pills were determined and that it was found that the absorption of ciprofloxacin can be decreased by simultaneous consumption of grape fruit juice [27].…”

Section: Resultsmentioning

confidence: 99%

Pilot Study: Assessment of Drug-Food and Drug-Drug Interactions in the Outpatient Settings

Ahmed

Alkhawaja

Khan

2020

JPRI

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Background: A drug-drug interaction arises when the pharmacologic effect of a medication is changed by the action of other medication causing unexpected clinical effects. Drug-drug interactions are widely known but the identification of the consequences of food and drug interactions has been growing slowly. Aim: The present study aims to describe the occurrence of drug –food and drug-drug interactions in the outpatient settings in Riyadh city. Methodology: A retrospective study was piloted in Riyadh city. The prescriptions were reviewed to identify potential drug - food and drug–drug interactions using Drug Interactions Checker. Results: About 16.16% of the prescriptions included a drug - drug interaction. The most frequent interaction was the interaction between ciprofloxacin and metronidazole (25.00%) that is a minor interaction. Regarding drug – food interactions there were 40 interactions, the majority of these interactions were moderate. The most common drug - food interactions were metronidazole with food (20.00%) that is a major interaction. Conclusion: Drug interactions with other drugs or with foods are common. These interactions could have a beneficial or a harmful effect. Physicians and pharmacists should use programs that detects the drug interactions.

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Effect of five Alive&#174 fruit juice on the dissolution and absorption profiles of ciprofloxacin

Cited by 9 publications

References 0 publications

Food Drug Interactions

Food Drug Interactions

An in vitro–in vivo correlation study for nifedipine immediate release capsules administered with water, alcoholic and non-alcoholic beverages: Impact of in vitro dissolution media and hydrodynamics

Pilot Study: Assessment of Drug-Food and Drug-Drug Interactions in the Outpatient Settings

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