Effect of functionalized titanium particles with dexamethasone-loaded nanospheres on macrophage polarization and activity

Chato-Astrain, Jesús; Toledano-Osorio, Manuel; Alaminos, Miguel; Toledano, Manuel; Sanz, Mariano; Osorio, Raquel

doi:10.1016/j.dental.2023.10.023

Dental Materials

2024

DOI: 10.1016/j.dental.2023.10.023

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Effect of functionalized titanium particles with dexamethasone-loaded nanospheres on macrophage polarization and activity

Jesús Chato-Astrain,

Manuel Toledano-Osorio,

Miguel Alaminos

et al.

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2024

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Cited by 2 publications

References 51 publications

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MCP-1 and IL-4 encapsulated hydrogel particles with macrophages enrichment and polarization capabilities for systemic lupus erythematosus treatment

Zhu,

Huang,

Luan

et al. 2024

Nano Res.

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MCP-1 and IL-4 encapsulated hydrogel particles with macrophages enrichment and polarization capabilities for systemic lupus erythematosus treatment

Zhu,

Huang,

Luan

et al. 2024

Nano Res.

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Immune dysregulation and macrophage polarization in peri-implantitis

Li,

Guo

et al. 2024

Front. Bioeng. Biotechnol.

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The term “peri-implantitis” (peri-implantitis) refers to an inflammatory lesion of the mucosa surrounding an endosseous implant and a progressive loss of the peri-implant bone that supports the implant. Recently, it has been suggested that the increased sensitivity of implants to infection and the quick elimination of supporting tissue after infection may be caused by a dysregulated peri-implant mucosal immune response. Macrophages are polarized in response to environmental signals and play multiple roles in peri-implantitis. In peri-implantitis lesion samples, recent investigations have discovered a considerable increase in M1 type macrophages, with M1 type macrophages contributing to the pro-inflammatory response brought on by bacteria, whereas M2 type macrophages contribute to inflammation remission and tissue repair. In an effort to better understand the pathogenesis of peri-implantitis and suggest potential immunomodulatory treatments for peri-implantitis in the direction of macrophage polarization patterns, this review summarizes the research findings related to macrophage polarization in peri-implantitis and compares them with periodontitis.

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Effect of functionalized titanium particles with dexamethasone-loaded nanospheres on macrophage polarization and activity

Cited by 2 publications

References 51 publications

MCP-1 and IL-4 encapsulated hydrogel particles with macrophages enrichment and polarization capabilities for systemic lupus erythematosus treatment

MCP-1 and IL-4 encapsulated hydrogel particles with macrophages enrichment and polarization capabilities for systemic lupus erythematosus treatment

Immune dysregulation and macrophage polarization in peri-implantitis

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