Effect of garlic nanoparticles on bone marrow function and antioxidants status in experimentally anemic male rats

Abstract

Background and Objective: This study was aimed the possibility of using garlic(extract and nanoparticles) in alleviating of bone marrow function and antioxidant status in anemic male rats induced by phenylhydrazine(PHZ). Materials and methods: The CNP-G was prepared according to [1]. Anemia was induced by phenylhydrazine intraperitoneal (20 mg/kg) for 2 consecutive days. A total of 60 adult male albino rats were used in the present study, at the age of 2 months with body weight 195 ± 15gm were divided randomly to six equal groups (10 rats for each) and treated as follows for 8 weeks :- Control group:- in this group animals left without any treatment like negative control.T1: animals in this group was induced anemia and untreated as positive group. T2: animals in this group still normal (no anemic) but treated with daily dose 35.4mg/kg of extract garlic given orally by stomach tube. T3: animals in this group were induced anemia and treated with daily dose 35.4mg/kg of extract garlic given orally by stomach tube. T4: animals in this group still normal (no anemic) but treated with daily dose 35.4mg/kg of CNP-G given orally by stomach tube.