Effect of General and Spinal Anesthesia on Hepatic and Renal functions and Hemodynamic parameters of Iraqi Women Undergo Cesarean Section: Comparative Study

Mohammed, Ola K.; Alabbassi, Mustafa Ghazi; Aldujaili, Alaa Abdul-Mehdi; Shakoor, Dalia Abd Alkader; Almoossawi, Mohanned Mohammed Bakir

doi:10.32947/ajps.v18i2.478

Cited by 3 publications

(3 citation statements)

References 26 publications

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“…In our study, the result showed that core body temperature was not statistically significant between treatment sub-groups (Table 2; P= 0.107) which was consistent with the result of Vasanthy.j et al (25). However, the study of Igweagu et al (26) and Matsukawa et al (27) showed the core body temperature of participants was decreased after anesthesia. Our result showed that the incidence of shivering was 21.59% in participants which was 31.34% in participants who received no intervention, warmed cover, and fluid therapy; and 18.05% in participants who received tramadol, pethidine, or clonidine.…”

Section: Discussionsupporting

confidence: 87%

Management of shivering after spinal anesthesia in parturient

Shamsi

Ail²,

Rahimi

et al. 2022

ijhs

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Aim: This study aimed to evaluate and compare the effectiveness and safety of different methods of shivering control in patients with spinal anesthesia during cesarean delivery in Al-Abbas, Obstetrics and Gynecology (Imam Al-Hujjah), and Al Kafeel hospitals in Karbala. Methods: This cross-sectional study was conducted on pregnant women who have delivered from 2016 to 2022 in Karbala city. More than 90% of cesarean delivery in Karbala were conducted in 3 hospitals including Imam Al-Hujjah hospital, Al-Abbas, and Al Kafeel. Patients were selected by a simple random method and the sample size for each hospital was defined with the proportion to size method. The researcher-made checklist was used to collect the data and data were extracted from medical documents of patients. In case of huge missing data in medical documents, the patient was excluded from the study, and another patient was selected by the same method. Result: In this study, 755 patients were included to the study. The mean age of participants was 24.48 ± 4.56 years. The incidence of shivering was 21.59% in participants, which were 31.34% in participants who received no intervention, warmed cover, and fluid therapy; and 18.05% in participants who received tramadol, and pethidine, or clonidine.

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Section: Discussionsupporting

confidence: 87%

Management of shivering after spinal anesthesia in parturient

Shamsi

Ail²,

Rahimi

et al. 2022

ijhs

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“…According to our findings, the reduced incidence of liver injury following isoflurane may be explained by the drug's lower metabolism and superior preservation of hepatic blood flow [11]. Most surgical procedures are monitored with small changes in liver function tests, regardless of whether they are conducted under regional (epidural or spinal) or general anaesthesia [15]. During all surgical operations, anaesthesia lowers blood flow to the liver.…”

Section: Discussionmentioning

confidence: 77%

Immediate Effects of Anesthesia Agents on Liver Function

Afaf Hmza

2024

Alq J Med App Sci

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Anesthetic agents and types may deteriorate liver function; therefore, choosing anesthetics with less hepatotoxicity is important. The elevations of serum aminotransferase (AST), alanine transaminase (ALT), and alkaline phosphatase (ALP) levels are frequently observed after surgical procedures, whether performed under general or spinal (regional) anesthesia. Therefore, the study aimed to investigate and compare the changes in liver enzymes following general anesthesia and regional anesthesia. An observational sheet was used to obtain data from patients and then statistically analyzed using the IMB Statistical Package for Social Sciences (SPSS) Statistic software version (23). A significant difference in the liver enzymes levels change was determined with a p-value of < 0.05. it was observed that in both groups of general and regional anesthesia, the level of AST, ALT, and ALP enzymes was significantly elevated post-operative compared to pre-operative with (P=0.000), especially in the level of ALT enzyme. The current study indicated that both general and regional anesthesia caused increased liver enzymes.

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“…Prior research shows that anesthetic drugs, such as propofol and fentanyl, have an effect on the central nervous system and also on the endocrine and immune inflammatory system, attenuating the release of various types of cytokines and catecholamines into the blood flow and thus conferring protection on the immune reaction triggered by the endoscopic procedure [ 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Anesthesia Medication’s Impacts on Inflammatory and Neuroendocrine Immune Response in Patients Undergoing Digestive Endoscopy

Popa-Ion,

Boldeanu,

Gheonea

et al. 2024

Clinics and Practice

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The aim of this study was to explore the impact of anesthetic drugs currently used to perform lower digestive endoscopy on serum concentrations of inflammation markers and catecholamines. We selected 120 patients and divided them into three lots of 40 patients each: L1, in which no anesthetics were used; L2, in which propofol was used; and L3, in which propofol combined with fentanyl was used. All patients had serum concentrations of adrenaline/epinephrine (EPI), noradrenaline/norepinephrine (NE), tumor necrosis factor alpha (TNF-α), interleukin-4 (IL-4), IL-6, IL-8, and IL-10, taken at three time points: at the beginning of the endoscopic procedure (T0), 15 min after (T1), and 2 h after the end of the endoscopic procedure (T2). The results of the research showed changes in the levels of catecholamines and interleukins (ILs) at T0, with an increased response in L1 above the mean recorded in L2 and L3 (p < 0.001). At T1, increased values were recorded in all lots; values were significantly higher in L1. At T2, the values recorded in L3 were significantly lower than the values in L2 (student T, p < 0.001) and L1, in which the level of these markers continued to increase, reaching double values compared to T0 (student T, p < 0.001). In L2 at T1, the dose of propofol correlated much better with NE, EPI, and well-known cytokines. Our results show that propofol combined with fentanyl can significantly inhibit the activation of systemic immune and neuroendocrine response during painless lower digestive endoscopy.

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Effect of General and Spinal Anesthesia on Hepatic and Renal functions and Hemodynamic parameters of Iraqi Women Undergo Cesarean Section: Comparative Study

Cited by 3 publications

References 26 publications

Management of shivering after spinal anesthesia in parturient

Management of shivering after spinal anesthesia in parturient

Immediate Effects of Anesthesia Agents on Liver Function

Anesthesia Medication’s Impacts on Inflammatory and Neuroendocrine Immune Response in Patients Undergoing Digestive Endoscopy

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