Effect of ghrelin on the biochemical and histopathology parameters and spermatogenesis cycle following experimental varicocele in rat

Abstract

Ghrelin can improve the capacity of antioxidant enzymes to reduce the oxidative stress caused by varicocele and reduce spermatogenesis cycle. Therefore, special attention should be paid to ghrelin in studies evaluating antioxidant compounds in varicocele.

Potential Antioxidative Effects of Kolaviron on Reproductive Function in Streptozotocin-Induced Diabetic Wistar Rats

“…Data from the current study showed that the body, testes, and epididymal weights were significantly lower in STZ-induced diabetic rats than the nondiabetic control group (Figures 3-6). These findings are in agreement with previous studies that also demonstrated a significant decrease in body, testicular, and epididymal weights in diabetic rats [5,18,27,28,33,45,47]. Moreover, variations in animal body and organ weights have been reported to affect spermatogenesis, sperm quality, and sperm concentration [5,18,27,28,33,45,47].…”

“…The reduction in antioxidant enzymes has been previously reported in diabetic animals [20]. The observed reduction in antioxidant enzyme activities could be due to the oxidative inactivation of the enzyme by ROS or by the glycation of the enzymes [20,45]. The reduced activity of SOD, CAT, and GPX in the epididymal and testicular tissues has been observed following STZ induction of diabetes, and this may result in a number of deleterious effects due to the accumulation of superoxide radicals and H 2 O 2 .…”

“…Subsequently the body will start to use other macromolecules such as lipids and proteins as sources of energy [45]. This results in shrinking of muscle tissue accompanied by a rapid weight loss in diabetic animals [45,46]. Data from the current study showed that the body, testes, and epididymal weights were significantly lower in STZ-induced diabetic rats than the nondiabetic control group (Figures 3-6).…”

“…Insufficient insulin secretion or dysfunction of the signaling pathway results in a disturbance of glucose homeostasis. Subsequently the body will start to use other macromolecules such as lipids and proteins as sources of energy [45]. This results in shrinking of muscle tissue accompanied by a rapid weight loss in diabetic animals [45,46].…”

“…Antioxidant enzymes such as SOD, CAT, and GPX play a crucial role in protecting the testes and epididymal tissues against OS associated damage and male reproductive disorders [43][44][45].…”