Effect of green tea on the ultrastructure of the zona glomerulosa of the adrenal cortex in diabetic rats

Abdel-Hamid, Ghada A.; Abdel-Aal, Iman H.; El-Fark, Magdy

doi:10.1097/01.ehx.0000473762.42509.fc

Cited by 1 publication

(3 citation statements)

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“…In the present study, STZ-induced diabetes causes highly significant decrease in the rat's mean body weight and highly significant increase in mean adrenal weight. This is in agreement with the findings of the work of some scientists, who reported that diabetic rats had a significant reduction in their body weight and a significant increase in adrenal weight [22,23] . Some scientists attributed the reduction in body weight occurring with diabetes to excessive loss of tissue proteins, or deficiency of carbohydrate needed for the energy metabolism, which in turn leads to degradation of structural proteins and muscle wasting [24] .…”

Section: Discussionsupporting

confidence: 93%

“…The adrenal cortex has an important role in the activities of the human body. The adrenocortical zones synthesize and secrete steroid hormones as aldosterone and cortisone hormones that regulate and control metabolic processes within the major organ of the body [22] .…”

Section: Discussionmentioning

confidence: 99%

“…Reactive oxygen species (ROS) plays an important role in the pathogenesis of endothelial damage occuring with diabetes. Nitric oxide is one of the ROS and is produced by endothelial cells, which relaxes the smooth muscles; its increase results in vasodilation [22,27] .…”

Section: Discussionmentioning

confidence: 99%

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The possible ameliorating effect of barley grain on the histological structure of the adrenal cortex in streptozotocin (STZ)-induced diabetes in adult male albino rats

Soliman

Noya

2019

Egyptian Journal of Histology

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Background: Diabetes is one of the most common endocrine disorders caused by lack of, or reduced insulin action leading to increase in blood glucose level and metabolic disorders in the body. Diabetes causes severe degeneration within the cells of adrenal cortex. Barley grain is known to be beneficial in regulating sugar, insulin, and cholesterol responses to foods. However, studies about its effect on the structure of adrenal cortex in diabetes are limited. Objective: This work aimed to evaluate the possible protective effect of barley grain on the histological changes within the adrenal cortex in streptozotocin-induced diabetes in adult male albino rats. Materials and Methods: Forty adult male albino rats were used in the study. They were divided into four groups of ten each: group I was the control group; group II received barley grain extract intragastrically; group III included rats with streptozotocin (STZ)-induced diabetes; and group IV received barley green extract after inducing diabetes. After 12 weeks, Rats were sacrificed by using ether anesthesia. Blood plasma was collected for hormonal analysis then adrenal tissue was used for histological and immunohistochemical studies. Results: STZ-induced diabetes resulted in a significant decrease in body weight and serum aldosterone and corticostrione levels and significant increase in adrenal weight. The cells of adrenal cortex appeared disorganized. Their nuclei appeared pyknotic with vacuolated cytoplasm. The blood sinusoids in-between the cells of adrenal cortex appeared dilated and congested. Distorted smooth endoplasmic reticulum and degenerated (mouse-bitten) mitochondria were also detected within the cells. Administration of barley grain after induction of diabetes led to amelioration of these changes. Conclusion: Barley grain extract administration improved the histological and biochemical changes induced by diabetes in adrenal cortex.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%