Effect of guanidinoacetic acid on performance, egg quality, yolk fatty acid composition, and nutrient digestibility of aged laying hens fed diets with varying substitution levels of corn with low-tannin sorghum

An Assessment of the Effects of Guanidinoacetic Acid on the Performance and Immune Response of Laying Hens Fed Diets with Three Levels of Metabolizable Energy

“…An increase in egg production and mass was observed in diets with low ME levels that included 0.08% GAA. This result partially coincides with that reported by some authors, who indicated that GAA increases Cr synthesis and improves reproductive behavior in hens [ 23 ]. However, the results of the present study contrast with the findings of other studies that indicate that the inclusion of 0.46% GAA reduces egg mass [ 34 ]; however, its inclusion in the range of 0.057% to 0.171% has no effect [ 29 ].…”

“…GAA, a stable and highly available additive, has been reported to optimize energy use by efficiently converting Cr in the bodies of birds, cattle, and humans [ 4 , 23 , 24 ]. It has been reported that GAA stimulates the insulin response and the secretion of insulin-like growth factor-1 (IGF1) [ 24 ], and, as previously stated, GAA catabolism generates arginine and glycine, and, all together, hormonal signals and amino acid levels stimulate the activity of the mTORC1 signaling pathway [ 25 ].…”