Effect of helicokinins and ACE inhibitors on water balance and development of Heliothis virescens larvae

Seinsche, A; Dyker, Hubert; Lösel, Peter; Backhaus, Dirk; Scherkenbeck, Jürgen

doi:10.1016/s0022-1910(00)00065-2

Cited by 52 publications

(36 citation statements)

References 43 publications

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“…Our results agree with those reported by Seinsche et al (2000) who tested the effect of ACE-inhibitors on the development of Heliothis virescens larvae. They found that larvae injected with captopril, enalaprilmaleate, and lisinopril, three inhibitors of ACE, November 2004 grew normally.…”

Section: Discussionsupporting

confidence: 93%

The angiotensin converting enzyme inhibitor captopril reduces oviposition and ecdysteroid levels in Lepidoptera

Vercruysse

Gelman

Raes

et al. 2004

Arch Insect Biochem Physiol

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The role of angiotensin converting enzyme (ACE, peptidyl dipeptidase A) in metamorphic- and reproductive-related events in the Egyptian cotton leafworm, Spodoptera littoralis (Lepidoptera, Noctuidae) was studied by using the selective ACE inhibitor captopril. Although oral administration of captopril had no effect on larval growth, topical administration to new pupae resulted in a large decrease of successful adult formation. Oviposition and overall appearance of adults emerging from treated larvae did not differ significantly from those emerging from non-treated larvae. In contrast, topical or oral administration of captopril to newly emerged adults caused a reduction in oviposition. By evaluating the effect of captopril on ecdysteroid titers and trypsin activity, we revealed an additional physiological role for ACE. Captopril exerted an inhibitory effect on ecdysteroid levels in female but not in male adults. Larvae fed a diet containing captopril exhibited increased trypsin activity. A similar captopril-induced increase in trypsin activity was observed in female adults. In male adults, however, captopril elicited reduced levels of trypsin activity. Our results suggest that captopril downregulates oviposition by two independent pathways, one through ecdysteroid biosynthesis regulation, and the other through regulation of trypsin activity. Apparently, fecundity is influenced by a complex interaction of ACE, trypsin activity, and ecdysteroid levels.

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Section: Discussionsupporting

confidence: 93%

The angiotensin converting enzyme inhibitor captopril reduces oviposition and ecdysteroid levels in Lepidoptera

Vercruysse

Gelman

Raes

et al. 2004

Arch Insect Biochem Physiol

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“…Kinin family peptides of insects from Orthoptera, Dictyoptera, Lepidoptera, and Diptera are in general diuretic, but with different levels of efficacy (Gäde and Goldsworthy, 2003). Seinsche et al (2000) described how a combination of helicokinin HezK I and 1 mmol of captopril or enalapril-maleate led to drastic weight decreases and higher mortality. It was suggested that ACE inhibitors could prohibit the hydrolysis of HezK I, resulting in a persistency of the peptide causing weight loss probably by water loss (Seinsche et al, 2000).…”

Section: Discussionmentioning

confidence: 99%

“…They have been isolated from a number of insects and stimulate contractions in the isolated cockroach hindgut and are also involved in ion and water balance through their diuretic activity (Holman et al, 1987;Coast et al, 1990;Zubrzak et al, 2007). Kinins and kinin analogues also inhibit weight gain in larval Heliothis virescens and Helicoverpa zea (Nachman et al, 2002;Seinsche et al, 2000). Kinin peptide analogues that are resistant to housefly ACE and Drosophila Ance, respectively, were synthesized by incorporating the sterically hindered aminoisobutyric acid (Aib) or by replacing a-amino acids by b-amino acids (Nachman et al, 2002;Zubrzak et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Effect of ace inhibitors and TMOF on growth, development, and trypsin activity of larval Spodoptera littoralis

Lemeire

Borovsky

Camp

et al. 2008

Arch Insect Biochem Physiol

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Angiotensin converting enzyme (ACE) is a zinc metallopeptidase capable of cleaving dipeptide or dipeptideamide moieties at the C-terminal end of peptides. ACE is present in the hemolymph and reproductive tissues of insects. The presence of ACE in the hemolymph and its broad substrate specificity suggests an important role in processing of bioactive peptides. This study reports the effects of ACE inhibitors on larval growth in the cotton leafworm Spodoptera littoralis. Feeding ACE inhibitors ad lib decreased the growth rate, inhibited ACE activity in the larval hemolymph, and down-regulated trypsin activity in the larval gut. These results indicate that S. littoralis ACE may influence trypsin biosynthesis in the larval gut by interacting with a trypsin-modulating oostatic factor (TMOF). Injecting third instar larvae with a combination of Aea-TMOF and the ACE inhibitor captopril, down-regulated trypsin biosynthesis in the larval gut indicating that an Aea-TMOF gut receptor analogue could be present. Injecting captopril and enalapril into newly molted fifth instar larvae stopped larval feeding and decreased weight gain. Together, these results indicate that ACE inhibitors are efficacious in stunting larval growth and ACE plays an important role in larval growth and development.

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“…In addition, recent studies have suggested the involvement of leucokinins in dietary regulation and energy mobilisation Seinsche et al, 2000). As such, the insect leucokinins have attracted a great deal of interest as lead molecules for novel pesticides, including the development of peptidaseresistant analogues of this family of peptides (Teal et al, 1999).…”

mentioning

confidence: 99%

Functional characterisation of theAnophelesleucokinins and their cognate G-protein coupled receptor

Radford

Terhzaz

Cabrero

et al. 2004

Journal of Experimental Biology

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Drosophila leucokinin was also found to activate the Anopheles receptor with a similar EC 50 value to Anopheles leucokinin I. However, when the Anopheles peptides were applied to the Drosophila receptor, only Anopheles leucokinin I and II elicited a rise in [Ca 2+ ] i . This suggests that the Anopheles receptor has a broader specificity for leucokinin ligands than the Drosophila receptor.Antisera raised against the Anopheles receptor identified a doublet of approx. 65 and 72·kDa on western blots, consistent with the presence of four N-glycosylation sites within the receptor sequence, and the known glycosylation of the receptor in Drosophila. In Anopheles tubules, as in Drosophila, the receptor was localised to the stellate cells.Thus we provide the first identification of Anopheles mosquito leucokinins (Anopheles leucokinins) and a cognate leucokinin receptor, characterise their interaction and show that Dipteran leucokinin signalling is closely conserved between Drosophila and Anopheles.

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Effect of helicokinins and ACE inhibitors on water balance and development of Heliothis virescens larvae

Cited by 52 publications

References 43 publications

The angiotensin converting enzyme inhibitor captopril reduces oviposition and ecdysteroid levels in Lepidoptera

The angiotensin converting enzyme inhibitor captopril reduces oviposition and ecdysteroid levels in Lepidoptera

Effect of ace inhibitors and TMOF on growth, development, and trypsin activity of larval Spodoptera littoralis

Functional characterisation of theAnophelesleucokinins and their cognate G-protein coupled receptor

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