The work is aimed at the development of application methods of graminicides and anti-dicotyledonous herbicides on oil flax in the area of unstable moistening of the south of Russia. The application of preparations against dicotyledonous weeds Tifi, Sekator Turbo or Magnum, followed by the treatment of sowings with Miura graminicide, contributed to obtaining an increase in yield of 0.14, 0.12, and 0.11 t/ha, respectively, in comparison to the untreated sowings. We observed an increase in crop yield by 0.09-0.12 t/ha with the application of anti-dicotyledonous herbicide Cleo and graminicide Miura, regardless of their application method. The tank mixtures Tifi + Miura and Magnum + Miura had a phytotoxic effect on oil flax, which, in comparison to the control, led to a decrease in yield by 0.04 and 0.09 t/ha and in oil content of seeds by 1.1 and 0.8%, respectively.