Effect of High-Intensity Interval Training, Moderate Continuous Training, or Guideline-Based Physical Activity on Peak Oxygen Uptake and Myocardial Fibrosis in Patients With Myocardial Infarction: Protocol for a Randomized Controlled Trial

Shi, Xiaohe; Chen, Xianyuan; Qiu, Xinfan; Luo, Wei; Luo, Xinyi; Liu, Hui; Geng, Qingshan; Ma, Huan; Li, Xue; Guo, Lina

doi:10.3389/fcvm.2022.860071

Cited by 6 publications

(5 citation statements)

References 37 publications

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“…Peak

, expressed as mL/kg/min, was determined as the highest 30-second average of

achieved during the test. This protocol has been employed in our previous research to assess Peak

in both myocardial infarction patients and those with pulmonary hypertension [ 20 , 26 ].…”

Section: Methodsmentioning

confidence: 99%

A Comprehensive Assessment of the Chinese Version of the Duke Activity Status Index in Patients with Cardiovascular Diseases

Liao,

Zhou,

Liu

et al. 2024

Rev. Cardiovasc. Med.

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Background: Exercise capacity serves as a direct representation of cardiac function. The Duke Activity Status Index (DASI), a self-administered 12-item questionnaire, covers aspects of daily living, household tasks, sexual function, and physical activity. Although widely used to evaluate exercise capacity, its validation in Chinese cardiovascular disease (CVD) patients has not been thoroughly explored. Considering the significant cultural and lifestyle differences between China and Western countries, which may influence Chinese patients’ comprehension and responses to DASI, our objective is to culturally adapt DASI for Chinese patients with CVD to ensure its precision in assessing exercise capacity. Methods: The cultural adaptation of the original DASI questionnaire into Chinese followed a rigorous process to ensure its validity, reliability, and sensitivity to Chinese CVD patients. The study included 107 outpatients diagnosed with CVD who completed the DASI and cardiopulmonary exercise testing (CPET). Cronbach’s alpha, Spearman correlation, and factor analysis were utilized to test reliability and validity. Receiver operating characteristic (ROC) curve analysis was employed to assess the prognostic utility of the DASI. Results: Participants had a mean DASI score of 39.40 10.75 and a peak oxygen uptake (Peak ) of 19.53 5.89 mL/min/kg. The Chinese version of the DASI exhibited satisfactory reliability and validity in CVD patients, with a Chronbach’s alpha coefficient of 0.706. The DASI score demonstrated a moderate correlation with Peak measured by CPET (r = 0.67, p 0.001). Factor analysis yielded three factors, accounting for 56.76% of the total variance, with factor 1 contributing to 26.38% of the variance. ROC curve analysis demonstrated that the DASI exhibited discriminative utility in the identification of patients with improved long-term prognosis ( p 0.001). The ROC curve had an area of 0.788 [95% confidence interval (CI) = 0.704–0.871]. The DASI score 36.85 served as the optimal threshold for enhanced long-term prognosis, exhibiting a sensitivity of 0.80 and a specificity of 0.69. Conclusions: The culturally adapted DASI questionnaire is a straightforward and efficient tool for reasonably evaluating exercise capacity in Chinese CVD patients.

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“…Peak

, expressed as mL/kg/min, was determined as the highest 30-second average of

achieved during the test. This protocol has been employed in our previous research to assess Peak

in both myocardial infarction patients and those with pulmonary hypertension [ 20 , 26 ].…”

Section: Methodsmentioning

confidence: 99%

A Comprehensive Assessment of the Chinese Version of the Duke Activity Status Index in Patients with Cardiovascular Diseases

Liao,

Zhou,

Liu

et al. 2024

Rev. Cardiovasc. Med.

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show abstract

“…We anticipate that 70% of the trial cohort will participate in the study, and they will be scheduled for a cardiopulmonary exercise test (CPET). The test regimen has been reported among cardiovascular patients in our prior study 32. Data collected in the CPET will be used to explore the relationship between preoperative cardiopulmonary fitness and clinical outcomes, including major postoperative complications and mortality.…”

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

“…The test regimen has been reported among cardiovascular patients in our prior study. 32 Data collected in the CPET will be used to explore the relationship between preoperative cardiopulmonary fitness and size calculation The sample size was calculated using inference for proportions comparing two independent samples performed by nQuery Advisor+nTerim 4.0 (Statistical Solutions, Ireland). Data from the pilot study (to be submitted) showed that the incidence in the primary endpoint was 13.56% (intervention group) vs 21.21% (control group).…”

Section: Ancillary Studymentioning

confidence: 99%

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Protocol for the PORT study: short-term perioperative rehabilitation to improve outcomes in cardiac valvular surgery – a randomised control trial

Zhou,

Liu,

Liu

et al. 2023

BMJ Open

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IntroductionPerioperative rehabilitation (PORT) has shown a positive effect on patients undergoing cardiac surgery. However, there are minimal data on the impact of short-term PORT in cardiac surgery, which is associated with higher postoperative morbidity and mortality. The trial will assess the efficacy of short-term PORT in reducing in-hospital mortality, postoperative pulmonary complications and length of stay, compared with the usual care in cardiac surgical patients.Methods and analysisThis is a single-centre prospective, randomised, open, controlled trial with a 1:1 ratio. Consecutive 800 adult patients undergoing elective valve surgery will be randomised to either usual care or in-hospital short-term PORT that consists of education, inspiratory muscle training, active cycle of breathing techniques and early mobilisation. The primary outcome of this study will be a composite of in-hospital all-cause mortality, incidence of postoperative pulmonary complications and the ratio of postoperative hospitalisation >7 days.Ethics and disseminationThe PORT study was granted by the Medical Research Ethics Committee of Guangdong Provincial People’s Hospital in August 2018. Findings will be disseminated to patients, clinicians and commissioning groups through peer-reviewed publication.Trial registration numberNCT03709511.

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“…PeakVO 2 was derived from respiratory gas analysis during maximal exercise testing and recorded in per kg body mass per min (mL/kg/min). This regimen has been utilized to measure peakVO 2 among myocardial infarction patients in our prior study [29].…”

Section: Assessment Of Exercise Capacitymentioning

confidence: 99%

Usefulness of the Duke Activity Status Index to Assess Exercise Capacity and Predict Risk Stratification in Patients with Pulmonary Arterial Hypertension

Zhou

Wang

et al. 2023

JCM

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Exercise capacity is an important component of risk assessment for pulmonary arterial hypertension (PAH). We investigated the association of the Duke Activity Status Index (DASI) with peak oxygen consumption (peakVO2) and explored whether the DASI can discriminate the high-risk individuals in patients with PAH, according to peakVO2 < 11 mL/min/kg. A total of 89 patients were evaluated using cardiopulmonary exercise testing (CPET) and DASI. The correlation between the DASI and peakVO2 was measured by univariate analysis, and a receiver operating characteristic (ROC) curve analysis was conducted. The DASI was correlated with peakVO2 in the univariate analysis. The ROC curve analysis revealed that the DASI had a discriminative value for identifying the individuals with a high risk in PAH patients (p < 0.001), with an area under ROC curve (AUC) of 0.79 (95% CI: 0.67–0.92). Similar results were observed in patients with PAH associated with congenital heart disease (CHD–PAH), (p = 0.001), with an AUC of 0.80 (95% CI: 0.658–0.947). Therefore, DASI reflects exercise capacity in patients with PAH and has good ability to discriminate patients with a low risk and a high risk, and it may be included in the risk assessment of PAH.

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Effect of High-Intensity Interval Training, Moderate Continuous Training, or Guideline-Based Physical Activity on Peak Oxygen Uptake and Myocardial Fibrosis in Patients With Myocardial Infarction: Protocol for a Randomized Controlled Trial

Cited by 6 publications

References 37 publications

A Comprehensive Assessment of the Chinese Version of the Duke Activity Status Index in Patients with Cardiovascular Diseases

A Comprehensive Assessment of the Chinese Version of the Duke Activity Status Index in Patients with Cardiovascular Diseases

Protocol for the PORT study: short-term perioperative rehabilitation to improve outcomes in cardiac valvular surgery – a randomised control trial

Usefulness of the Duke Activity Status Index to Assess Exercise Capacity and Predict Risk Stratification in Patients with Pulmonary Arterial Hypertension

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