Effect of HPMC and mannitol on drug release and bioadhesion behavior of buccal discs of buspirone hydrochloride: In-vitro and in-vivo pharmacokinetic studies

Abstract

Delivery of orally compromised therapeutic drug molecules to the systemic circulation via buccal route has gained a significant interest in recent past. Bioadhesive polymers play a major role in designing such buccal dosage forms, as they help in adhesion of designed delivery system to mucosal membrane and also prolong release of drug from delivery system. In the present study, HPMC (release retarding polymer) and mannitol (diluent and pore former) were used to prepare bioadhesive and controlled release buccal discs of buspirone hydrochloride (BS) by direct compression method. Compatibility of BS with various excipients used during the study was assessed using DSC and FTIR techniques. Effect of mannitol and HPMC on drug release and bioadhesive strength was studied using a 3(2) factorial design. The drug release rate from delivery system decreased with increasing levels of HPMC in formulations. However, bioadhesive strength of formulations increased with increasing proportion of HPMC in buccal discs. Increased levels of mannitol resulted in faster rate of drug release and rapid in vitro uptake of water due to the formation of channels in the matrix. Pharmacokinetic studies of designed bioadhesive buccal discs in rabbits demonstrated a 10-fold increase in bioavailability in comparison with oral bioavailability of buspirone reported.

Reduction of intraocular pressure using timolol orally dissolving strips in the treatment of induced primary open-angle glaucoma in rabbits

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Microfluidic Fabrication of Hydrocortisone Nanocrystals Coated with Polymeric Stabilisers

“…HPMC is a biodegradable and biocompatible excipient, generally recognized as safe by the US Food and Drug Administration (FDA). It is widely used in pharmaceutical formulations [ 55 , 56 ].…”

Formualtion and Development of Mucoadhesive Sustained Release Buccal Tablets and Patches of 5-Fluorouracil Using Different Polymers

“…The swollen tablets and patches were then reweighed (W2). This experiment was performed in triplicate [25]. The degree of swelling (water uptake) was calculated according to the following formula:…”