Effect of human recombinant interferon on cytotoxic activity of natural killer (NK) cells and monocytes

Herberman, Ronald B.; Ortaldo, John R.; Mantovani, Alberto; Hobbs, Donna S.; Kung, Hsiang Fu; Pestka, Sidney

doi:10.1016/0008-8749(82)90208-8

Cited by 133 publications

(29 citation statements)

References 31 publications

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“…[86][87][88][89] For example, IL-2 increases ADCC by NK cell expansion and activation 88 and a correlation between NK cell counts and clinical response was found in a clinical trial combining IL-2 and rituximab in patients with NHL. 90 IL-12 enhances the lytic activity of NK cells and induces IFN-␥.…”

Section: Recruitment Of Fc␥ Receptor-dependent Functionsmentioning

confidence: 99%

From the bench to the bedside: ways to improve rituximab efficacy

Cartron

Watier

Golay

et al. 2004

Blood

484

320

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Section: Recruitment Of Fc␥ Receptor-dependent Functionsmentioning

confidence: 99%

From the bench to the bedside: ways to improve rituximab efficacy

Cartron

Watier

Golay

et al. 2004

Blood

484

320

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“…Under these conditions IFN treatment produced 2-to 3-fold increases in lysis of K562 cells. This is comparable to the effects on NK cell-mediated lysis produced by other IFN preparations, including recombinant human leukocyte IFN [19] and fibroblast IFN [24]. A direct comparison of IFN-791T/36 conjugate with free IFN is not possible because of the inherent difficulties in defining purity of IFN preparations derived from the human lymphoblastoid cell line Namalwa [1].…”

Section: Discussionmentioning

confidence: 59%

Interferon-? conjugation to human osteogenic sarcoma monoclonal antibody 791T/36

Pelham

Gray

Flannery

et al. 1983

Cancer Immunol Immunother

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Human lymphoblastoid interferon-alpha (IFN-alpha) has been coupled using N-succinimidyl 3-(2-pyridyldithio) propionate (SPDP) to a murine monoclonal antibody (791T/36) which reacts with antigens expressed on human osteogenic sarcomas. The purified conjugates retain antibody activity as defined by their capacity to compete with binding of fluorescein isothiocyanate-labelled 791T/36 antibody to 791T cells. IFN-alpha-791T/36 antibody conjugates synthesized with 125I-trace-labelled IFN-alpha and 131I-trace-labelled antibody also bound to 791T cells, but not to bladder carcinoma T24 cells. The conjugates also retain the capacity of free IFN to activate natural killer cells in human peripheral blood lymphocytes and show specific localization in human osteogenic sarcoma xenografts developing in immunodeprived mice. These findings establish that conjugates containing IFN linked to a monoclonal antibody reacting with osteogenic sarcoma-associated antigens have potential for targeted immunotherapy and in related investigations with antibody has been shown by gamma camera imaging of patients following infusion of 131I-labelled antibody to localize in primary osteogenic sarcomas.

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“…However, morphological signs of macrophage activation are probably not correlated with cytostatic potency since IBDV infection, which is known not to infect avian T-lymphoblastoid cells (Hirai and Calnek, 1979), caused the.same changes in macrophage morphology as LK, but induced only marginal cytostatic activity. The possible role of IF in this experimental system remains to be investigated since it has been shown by Herberman et al (1982) that ß-and 7-interferon could induce cytotoxic activity of human monocytes.…”

Section: Discussionmentioning

confidence: 99%