Effect of Hyaluronic Acid Gel on Healing of Simple Dental Extraction Sockets: A Pilot Study

Mostafa, Diana; Alzahrani, Maram; Alatawi, Jawharah Atiah; Alsirhani, Samar Farhan; Alshehri, Afrah; Almutiri, Afnan Mazyed

doi:10.3889/oamjms.2021.6913

Cited by 3 publications

(1 citation statement)

References 22 publications

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“…44 In a pilot split mouth study conducted in 10 patients by Mostafa D, it was reported that HA enhances the socket healing and can be used as supportive treatment to improve the wound healing. 46 The above studies suggest that HA can effectively reduce pain & inflammation and may hasten the healing process in extraction socket.…”

Section: Clinical Evidence On the Role Of Ha In Post-extraction Healingmentioning

confidence: 95%

Role of hyaluronic acid in post-extraction healing

Shukla,

Pebilli

2023

JOOO

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In dental practice, rapid healing of post-extraction wounds is integral in reducing the risk of infection that causes patient discomfort. Wound healing is a dynamic process requiring adequate vascularization and collagen matrix deposition. The renewal of vessels determines traction that stimulates remodelling of the extracellular matrix, potentiating neo-vessel responses. The presence of topical agents may aid the regenerative and repair mechanisms & improve the healing process of damaged tissues. Commercial preparations based on low molecular weight hyaluronic acid (HA) have shown to improve the healing of connective tissue, epithelium, and mucosa. HA is used during the healing process as it primarily creates a temporary structure for depositing extracellular matrix (ECM) proteins, initiates cell adhesion, proliferation, and migration, and regulates vascular endothelial cell function. The present review article discusses the possible complications of delayed post-extraction healing and the role of hyaluronic acid in post-extraction wound healing and alveolar osteitis.

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Section: Clinical Evidence On the Role Of Ha In Post-extraction Healingmentioning

confidence: 95%

Role of hyaluronic acid in post-extraction healing

Shukla,

Pebilli

2023

JOOO

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Hyaluronic acid in tooth extraction: a systematic review and meta-analysis of preclinical and clinical trials

Domic,

Bertl,

Lang

et al. 2023

Clin Oral Invest

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Objectives To assess whether in animals or patients with ≥ 1 tooth extracted, hyaluronic acid (HyA) application results in superior healing and/or improved complication management compared to any other treatment or no treatment. Materials and methods Three databases were searched until April 2022. The most relevant eligibility criteria were (1) local application of HyA as adjunct to tooth extraction or as treatment of alveolar osteitis, and (2) reporting of clinical, radiographic, histological, or patient-reported data. New bone formation and/or quality were considered main outcome parameters in preclinical studies, while pain, swelling, and trismus were defined as main outcome parameters in clinical studies. Results Five preclinical and 22 clinical studies (1062 patients at final evaluation) were included. In preclinical trials, HyA was applied into the extraction socket. Although a positive effect of HyA was seen in all individual studies on bone formation, this effect was not confirmed by meta-analysis. In clinical studies, HyA was applied into the extraction socket or used as spray or mouthwash. HyA application after non-surgical extraction of normally erupted teeth may have a positive effect on soft tissue healing. Based on meta-analyses, HyA application after surgical removal of lower third molars (LM3) resulted in significant reduction in pain perception 7 days postoperatively compared to either no additional wound manipulation or the application of a placebo/carrier. Early post-operative pain, trismus, and extent of swelling were unaffected. Conclusions HyA application may have a positive effect in pain reduction after LM3 removal, but not after extraction of normally erupted teeth. Clinical relevance HyA application may have a positive effect in pain reduction after surgical LM3 removal, but it does not seem to have any impact on other complications or after extraction of normally erupted teeth. Furthermore, it seems not to reduce post-extraction alveolar ridge modeling, even though preclinical studies show enhanced bone formation.

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Effect of Intra-socket Application of Hyaluronic Acid Gel on Soft and Hard Tissue Healing Following Impacted Mandibular Third Molars Extraction(a Randomized Controlled Clinical Trial)

Elkady,

Sweedan,

Amer

2024

Preprint

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Background One of the most frequent dental operations is the surgical extraction of an impacted third molar. The study aimed to evaluate the impact of the intra-socket application of 0.8% hyaluronic acid (HA) gel on hard & soft tissue healing after surgical removal of the impacted 3rd molar. Objective Materials and methods This randomized controlled clinical study included thirty patients aged from 21–36 years who were scheduled for surgical removal of impacted mandibular third molar. 0.8% hyaluronic acid gel (HA group) was applied immediately after surgery in the intra-socket of 15 patients, and nothing (No HA group) was applied to the socket of the other 15 patients. Soft and hard tissue healing was assessed after extraction on the third, seventh, and fourteenth day. Results The soft tissue healing index was significantly better (very good or excellent) in the HA group compared with no HA group after fourteen days postoperative (p < .001). Also, the percentage increase of bone density in the HA group was statistically significantly higher after two months than in the no HA group ((p < .001) Conclusion Hyaluronic acid 0.8% gel application improves soft tissue healing and bone density healing following surgical extraction of the mandibular third molar. It could be considered a valuable material for improving bone healing and soft tissue. Trial registration The trial is retrospectively registered at the Pan African Clinical Trial Registry with the identification number for the registry PACTR202407576478340.

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Effect of Hyaluronic Acid Gel on Healing of Simple Dental Extraction Sockets: A Pilot Study

Cited by 3 publications

References 22 publications

Role of hyaluronic acid in post-extraction healing

Role of hyaluronic acid in post-extraction healing

Hyaluronic acid in tooth extraction: a systematic review and meta-analysis of preclinical and clinical trials

Effect of Intra-socket Application of Hyaluronic Acid Gel on Soft and Hard Tissue Healing Following Impacted Mandibular Third Molars Extraction(a Randomized Controlled Clinical Trial)

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